So a controversial #DeltaVariant study did not find a sig 2-dose effect for Pfizer, yet still claims a significant efficacy. It also claims AstraZeneca hospitalization relative risk is lower than Pfizer—opposite last week—also from weak case control design—wouldn’t bank on it. 🧵
2) This (left photo) is the standard VE formula. Yet this (right photo) is the modified calculation of VE used in this study. It requires a completely diff set of assumptions and then mashes the two different sets of numbers together.
3) there are many assumptions in order for their formula. It’s very risky and tricky.
“Biased [vaccine efficacy] effect-size estimates arise if either condition is unmet.”
⚠️Annoyed—the US CDC still does **not seem to classify the #DeltaVariant as a “Variant of Concern”**!! #B16172 is still merely “variant of interest” on @CDCgov website, updated just this weekend. Both @WHO & 🇬🇧 upgraded Delta to VOC weeks ago. CDC act now! cdc.gov/coronavirus/20…
2) Because this is what new cases of #DeltaVariant#COVID19 is doing in the UK 🇬🇧… US 🇺🇸 is a trouble if don’t act now
Good news—Novavax protein-subunit vaccine phase 3 trial shown to to be 90.4% effective overall, 100% against moderate to severe disease. This is different type from mRNA and from AZ/J&J adenovirus vaccines, and different from inactivated types. #COVID19 nytimes.com/2021/06/14/hea…
2) Similar #DeltaVariant worries from a Canadian hospital— ➡️Outbreak even w/ 2 dose of mRNA vaccines—16 patients & 6 healthcare staff #DeltaVariant positive. 6/16 patients & 5/6 HCWs had received 2 doses of #COVID19 vaccine; 7 patients & 1 HCW had 1 dose cbc.ca/amp/1.6063802
📍Outbreak even w/ 2 dose of mRNA vaccines—🇨🇦 hospital—16 patients & 6 healthcare staff #DeltaVariant positive. 6/16 patients & 5/6 HCWs had received 2 doses of #COVID19 vaccine; 7 patients & 1 healthcare worker had 1 dose. 1 patient now in ICU. #dontletup cbc.ca/news/canada/ca…
2) Outbreaks of the delta variant at the Foothills Medical Centre in Calgary are sparking concern as some with both doses of the vaccine are still getting affected with the variant.
"We're scared, very concerned," said Wayne Stopa, a RN of United Nurses of Alberta Local 115.
3) "A lot of us have had the double vaccines already … and to find out people are still getting affected with the delta variants is quite concerning to all the staff."
Delta variant fears coming true—@WHO_Europe director says #DeltaVariant of #COVID19 is "poised to take hold"—#B16172 evades 1-dose vaccine & “shows increased transmissibility & some immune escape” & more severe. It is exponentially ⬆️ in 🇬🇧 & 🇺🇸 too.🧵 thehill.com/policy/healthc…
2) Hans Henri Kluge expressed concern about the Delta variant, known by the scientific name B.1.617.2, pointing to recent research appearing to show it can spread quickly and infect those who have received one of two vaccine doses at higher rates than the fully vaccinated.
3) "We have been here before."
"Over the course of last summer, cases gradually rose in younger age groups and then moved into older age groups, contributing to a devastating resurgence, lockdowns and loss of life in autumn and winter of 2020. Let's not make that mistake again."