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13 Jun, 13 tweets, 9 min read
5 Receptors, any more?
Molecular mechanism of interaction between SARS-CoV-2 and host cells and interventional therapy
researchgate.net/publication/35…
Sorry, I can't count properly, there are more than 5:
ACe2, Neuropilin 1, AXL, ASGR1, KREMEN1, Cellular heparan sulfate, CD147, DCL-SIGN, L-SIGN, MR, and MGL, maybe nicotinic acetylcholine receptors (nAChRs) via gp120 motif
Anyone still counting?
12 or more! That is unusual...
Nicotinic Receptors:
interaction of SARS-CoV-2 spike protein with nicotinic acetylcholine receptors
ncbi.nlm.nih.gov/pmc/articles/P…
Nicotinic cholinergic system and COVID-19
ncbi.nlm.nih.gov/pmc/articles/P…
SARS-CoV-2 spike protein and nicotinic acetylcholine receptors
ncbi.nlm.nih.gov/pmc/articles/P…
DCL/SIGN
DC/L-SIGN recognition of spike glycoprotein promotes SARS-CoV-2 trans-infection
biorxiv.org/content/10.110…
CD209L/L-SIGN and CD209/DC-SIGN act as receptors for SARS-CoV-2
ncbi.nlm.nih.gov/pmc/articles/P…
Neuropilin-1
NRP-1 facilitates SARS-CoV-2 cell entry & infectivity
science.sciencemag.org/content/370/65…
NRP-1 novel SARS-CoV-2 host cell entry mediator
nature.com/articles/s4139…
NRP-1: Novel Entry Factor for SARS-CoV-2
dovepress.com/neuropilin-1-a…
role of NRP-1 in COVID-19
journals.plos.org/plospathogens/…
AXL
AXL is a candidate receptor for SARS-CoV-2
nature.com/articles/s4142…
and
researchgate.net/publication/34…
ASGR1 and KREMEN1
Interaction network of SARS-CoV-2 with host receptome through spike protein
biorxiv.org/content/10.110…
Binding of the SARS-CoV-2 Spike Protein to the Asialoglycoprotein (ASGR1) Receptor
dovepress.com/binding-of-the…
on twitter
CD 147?
CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells
nature.com/articles/s4139…
or maybe not
Contradictory Results
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
biorxiv.org/content/10.110…
Summary of some SARS-CoV-2 cell entry mechanisms
acrobiosystems.com/A1247-A-summar…
LILRB2 and SIGLEC?
Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection
cell.com/molecular-ther…
LILRB2
frontiersin.org/articles/10.33…
DC-SIGN, MGL, Siglec-9 and Siglec-10
biorxiv.org/content/10.110…
Heparan Sulfate
COVID-19 Virus Uses Heparan Sulfate to Get Inside Cells
health.ucsd.edu/news/releases/…
Interactions Between Heparan Sulfate & SARS-CoV-2-Related Proteins
frontiersin.org/articles/10.33…
SARS-CoV-2 Infection Depends on Cellular Heparan
Sulfate and ACE2
cell.com/cell/pdf/S0092…
So, 12 or more?

Tell me, Boffins Anonymous, how many viruses can bind to 12 receptors?

Or is this just natural as well?

Interaction network of SARS-CoV-2 with host receptome through spike protein

biorxiv.org/content/10.110…
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More from @BillyBostickson

Billy Bostickson 🏴👁&👁 🆓 Profile picture
13 Jun
Watch It! Live Bats @WIV WORLD EXCLUSIVE
Thanks @SharriMarkson
Footage proves bats were kept in Wuhan lab

Well done @uacjess @interne41914499 and of course @billybostickson #DRASTIC
The Chinese Academy of Sciences video was discovered by researchers investigating the origin of the pandemic who call themselves DRASTIC.
Digital archivist “Jesse” @uacjess found the Chinese Academy of Sciences Video while the group's co-ordinator, who goes by a pseudonym of “Billy Bostickson” for safety reasons, has long complained evidence bats were housed in the Wuhan laboratories.
Read 5 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
13 Jun
1. "Why then tonight let us assay their plot." - Farrar
dailymail.co.uk/news/article-9…
Thanks to @ianbirrel
2. Let's further think of this,
Weigh what convenience both of time & means
May fit us to our shape. If this should fail,
& that our drift look through our bad performance,
'Twere better no assayed. Therefore this project
Should have a back or second that might hold
3. April 2020
Online Discussion chaired by NAM President Victor Dzau
Jeremy Farrar, Wellcome Trust
Anthony S. Fauci NIH
Sanjay Gupta, CNN
George F. Gao, DG, China CDC
Susan R. Weiss
Richard J. Hatchett
Coalition for Epidemic Preparedness Innovations
Read 17 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
12 Jun
1. Wuhan Institute of Virology and REMDESIVIR
(Patent and Paper)
Second analysis by Jian Kang, New York Medical College Associate Professor @jkssdk0907
The first analysis was posted yesterday here:
The National Natural Science Foundation of China
2. On February 4, 2020, the Wuhan Institute of Virology announced on its official website
whiov.cas.cn/kyjz_105338/20… (now deleted) that on January 21, 2020, it had declared a Chinese invention patent on the "use of anti-2019 novel coronavirus" Remdesivir.
archive.ph/88ecC
3. The experimental data that the application relied on was sent to Cell Research on January 25, 2020, and published as a Letter to the Editor on February 4th 2020 in the journal, Nature. (nature.com/articles/s4142…)
Read 12 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
11 Jun
The National Natural Science Foundation of China

1. Jian Kang, a retired associate professor from New York Medical College, pointed out the following evidence supporting the Laboratory leak of the SARS-COV-2 Virus
2. The National Natural Science Foundation of China provided zero funding for the research on the origin and intermediate host of the SARS-Cov-2 virus, while the funding for research on the origin and intermediate host of the SARS-1 virus was nearly 2 million.
3. The main supporting evidence for a natural origin of SARS-COV- 2 is finding the intermediate host.

From the perspective of profit & loss, the biggest beneficiary of finding an intermediate host is China, to show that the virus comes from nature, not a man-made disaster.
Read 14 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
10 Jun
1. The Yeast is Red and Many are Dead Thread
Sub Yeast Thread 1
2. via @ydeigin and @franciscodeasis
it’s a very disturbing paper if its findings are verified: not only SARS2 and RaTG13 have signs of genetic manipulation in yeast but SARS1 too.
WIV is known to have eyed yeast reverse genetic systems with interest (see attached WIV thesis
3. The Author has published quite a few interesting papers with 1870 citations.
scholar.google.com/citations?user…
One on the Association between influenza vaccination rates and SARS-CoV-2 outbreak infection rates in OECD countries
papers.ssrn.com/sol3/papers.cf…
Read 25 tweets
Billy Bostickson 🏴👁&👁 🆓 Profile picture
9 Jun
It's Fun Time with Yeast DNA! New paper!
Differential enrichment of yeast DNA in SARS-CoV-2 and related genomes supports synthetic origin hypothesis
46 Pages, Posted: Andreas Martin Lisewski
Jacobs University, June 5, 2021
papers.ssrn.com/sol3/papers.cf…
I will be reading this now
Crikey! SARS 1 SARS COV 2 and RaTG13!
Diagram 1
Read 13 tweets

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