Here is my @SkyNews interview with @skynewssarah on the delay to Step 4 of the Roadmap
- cases rising exponentially
- so are hospitalizations with a delay & a low starting point
- less than 1/2 the population have had 2nd dose
- Delta doesn't play fair

The Roadmap was calibrated against the Alpha/Kent variant. That's why the last two Roadmap tests were included: variants and hospitalizations
We knew before Step 3 was taken that Delta/B.1.617.2/the 'India' variant was more transmissible.
We didn't know *how much* more transmissible. But before Step 3, SPI-M projected how hospitalizations would change based on a variant being 10, 20, 30, 40, 50% more transmissible.
We have since found out that Delta is around 60% more transmissible (there is still some uncertainty).
We have since learnt that transmissibility is just one of the risks of Delta.
Today, for example, we have more information on infection severity.
We know that getting your second dose of the vaccine is critical to give the most protection against Delta (this is the 'vaccines' risk)
And *no-one* wants another lockdown.
So, where are we with cases and hospitalizations?

Here's a thread showing why I believe that cases and hospitalizations *have not* been decoupled
Cases are increasing exponentially. You can see this as the purple line on this chart

We can also see that hospitalizations lag behind cases.
But what about hospitalizations (in red)?

That's not so clear on this graph.
So we can plot the *growth* of cases and the *growth* of hospitalizations (with a bit of a lag) to see if there's a link.

We can see that the purple line and the red line are still linked.
What we do know is that vaccines work. That's why hospitalizations are starting from a relatively low level (lower than without vaccines).

But that just gives us a couple of weeks' head start. Hospitalizations follow cases.
And vaccinations stop hospitalizations.

We're not there yet.

We need more time for
- people to get their first doses
- those that have had their first dose to get their second dose
- more data on the link between cases and hospitalizations
And *nobody* wants another lockdown.

Hospitals are *very busy* with the non-Covid backlog from Lockdown 1, Lockdown 2, and Lockdown 3. There is little spare capacity for Covid patients.

*The reason for delaying Step 4 is to stop Lockdown 4*

Here is the latest analysis from data issued at 4pm today, 14 June.
- case growth rate 49% per week
- hospitalizations growth rate 47% per week
- patients in ICU/HDU beds increasing
- cases and hospitalizations *not* decoupled

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More from @Dr_D_Robertson

14 Jun
Here is the LSHTM paper on Roadmap Step 4
assets.publishing.service.gov.uk/government/upl…

A central scenario (assuming a delay of 4-5 weeks) bearing in mind there is still uncertainty.

But: a projection in this wave:

*43,500* (between 31,200-62,900) deaths

Peak deaths *500* (between 300-800) per day
Here is a thread giving more detail of the modelling used by LSHTM

Read 7 tweets
14 Jun
Let's look at the SAGE 92 minutes that would have informed the Government's thinking.

A thread.
assets.publishing.service.gov.uk/government/upl…
Additional material has also been released from meetings the previous week.

gov.uk/government/pub…
But back to the SAGE 92 consensus statement.

"R is now estimated to be 40–80% higher for delta than for alpha (B.1.1.7), although a figure higher or lower than this cannot be ruled out. "

*40 to 80%*
Read 17 tweets
13 Jun
We should not move to Step 4 on 21 June. A few extra weeks will allow more data to be gathered on hospitalizations

Test 4 (Variant test) is clearly not met
Test 3 (Infection Rates) may not be met as the *risk* still remains of a surge in hospitalizations

Image
The Delta variant changes the calibration of the response and needs to be taken very seriously.

We should also go back to the Roadmap to see what the plan is.

Read 6 tweets
11 Jun
I want to talk about 'decoupling'.

A thread.

The Government's reason for proceeding with the 17 May Step 3 unlocking was that vaccination means that cases are 'decoupled' from hospitalizations.

Here's the quote in Hansard.

hansard.parliament.uk/Lords/2021-05-…
The problem is: it's not clear to me that cases and hospitalizations *have* become decoupled.

It's worth reading this in conjunction with the SPI-M advice available to Government prior to Step 3 unlocking.

SPI-M's projection based on a variant (e.g. Delta/B.1.617.2) being more transmissible.
Read 18 tweets
9 Jun
Here are some charts showing what is going on with Covid cases and hospitalizations in England.

A thread.

Firstly, cases. In order that the graph doesn't get too spiky, we smooth it by taking the average cases in the previous 7 days. Here it is.
We're only really interested in what's happening now (and in the future), so let's look at the right hand bit. Cases are rising exponentially.
To show this, we can plot the case numbers on a logarithmic plot. If there's an exponential rise, this line should be straight.
Read 11 tweets
8 Jun
Let's look back at the SPI-M consensus statement from before Step 3 of the Roadmap.

A short thread.

assets.publishing.service.gov.uk/government/upl…
Read 12 tweets

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