Thread by @hanniepower

And that's @BSPparasitology's #ParasitesOnline conference just started with an address from @BSPparasitology President, Prof Maria-Gloria Basáñez of @imperialcollege! Delegates come from 53 countries worldwide! What a great week to come! #Parasitology

The first #ParasitesOnline Plenary Lecture is from Prof Philippe Guérin of @IDDOnews who is telling us about "Exploring the re-use of existing data for poverty-related diseases: a scientific or an ethical imperative or both?". #Parasitology @BSPparasitology

Prof Philippe Guerin describes how we need to better use existing data from scattered clinical trials, and have common standards for reporting and quality; continuing to develop an equitable data platform model (for #NTDs & other diseases). Here's a talk:

And now to begin the #ParasitesOnline Cell and Molecular Biology and Biochemistry Session I: Prof Carmen Faso of the Uni of Bern, who tells us about what we've learned (and have yet to learn) about Giardia (and Entamoeba) endocytosis and secretion! #Parasitology @BSPparasitology

Still an open question as to why Giardia has those two nuclei instead of one by the way! And right now, Prof Faso tells us about endocytosis in Giardia, citing this work (journals.plos.org/plospathogens/…) & new work to come from Santos et al! So keep an eye out for that! #ParasitesOnline

In addition, Prof Faso describes the clathrin-mediated endocytosis of Giardia lamblia: pubmed.ncbi.nlm.nih.gov/32092130/ and the possibility of a Giardia clathrin light chain analogue! More to come in that Santos paper in prep! #ParasitesOnline

So another paper to look out for in future: Hehl et al. This work regards Giardia encystation and you can find details about cyst wall protein 1 and it's role at ncbi.nlm.nih.gov/pmc/articles/P… So Giardia have no recognisable Golgi, but a Golgi-like apparatus! #ParasitesOnline

Prof Faso tells us about her current work in unconventional protein secretion (UPS) and using both Giardia and Entamaoba as models. Interesting- evidence for UPS in parasite-host communication and virulence. Some early work at pubmed.ncbi.nlm.nih.gov/29228011/ #ParasitesOnline

The second #ParasitesOnline talk of the Cell and Molecular Biology Session 1 is Abbie Williams from the University of Bristol, describing "Trends in temporal gene expression in adult parasitic and free-living #Strongyloides ratti." #Parasitology @BSPparasitology

Abbie Williams describes intergenerational gene expression in Strongyloides and identifies groups/clusters of gene families that may be important in the parasitic female and free-living female. #ParasitesOnline Look out for future papers in this area! @BSPparasitology

So I've popped over to the IDDO II Session with Dr Martin Walker of the @RoyalVetCollege and @IDDOnews who describes "Developing a research agenda for the sharing and reuse of clinical data on #schistosomiasis & soil-transmitted helminthiases." #ParasitesOnline @BSPparasitology

So you can find all about the Infectious Disease Data Observatory (IDDO) at iddo.org and follow at @IDDOnews. And there will be a freely available agenda/publication at @WellcomeOpenRes at some point as well! #ParasitesOnline @BSPparasitology

Now, Dr Walker describes some of his own recent work in soil-transmitted helminths & modelling NTD transmission to inform policy, trial design, and intervention planning. journals.plos.org/plosntds/artic… #ParasitesOnline @BSPparasitology

Having a fabulous breakfast here in the US while listening to @RussMorphew's keynote lecture about "Helminth Extracellular Vesicles: Drugs and Bugs", feat. his excellent work down in @AberUni! Check out frontiersin.org/articles/10.33… #ParasitesOnline @BSPparasitology

And now for Talk 2 of #ParasitesOnline's Cell and Molecular Biology and Biochemistry Session II: Santanu Sasidharan tells us about "Biochemical and inhibition studies on #Leishmania donovani tyrosine aminotransferase." @BSPparasitology

Oh wonderful! Santanu is discussing his work at @warangal_nit that was just published last year at sciencedirect.com/science/articl… Check it out! #ParasitesOnline @BSPparasitology

And sticking with kinetoplasts, but moving to #Trypanosoma, we have Dr Caroline Dewar of the University of Bern telling us about "Deciphering mitochondrial quality control in Trypanosoma brucei." #ParasitesOnline @BSPparasitology

Dr Dewar shows some recent work informing her current research. Just out this year in @PNASNews: pnas.org/content/118/6/… #ParasitesOnline

So keep an eye out for more from Dr Caroline Dewar about the proteins involved in MQC in #Trypanosoma brucei! #ParasitesOnline

And the final talk of this #ParasitesOnline session is from Mona Suleiman of the University of Bath who tells us about "Regulation of transposable elements in the absence of piRNAs in a clade IV nematode during a parasitic infection." @BSPparasitology

Mona Suleiman describes a pipeline for sequencing and classifying small RNAs in Strongyloides ratti, comparing differences between the parasitic and free-living female forms. It appears 21-22 Us are stage specific! But you'll have to wait for the publication to find out more!

And now for the 1st talk of #ParasiteOnline's Cell and Molecular Biology and Biochemistry Session III: Dr Benjamin Makepeace of @LivUni with "Wolbachia symbiont genomes and their transcriptional regulation in filariae and ectoparasites." @BSPparasitology #Parasitology

Dr Makepeace explains cytoplasmic incompatibility, citing this excellent #Wolbachia review from this year: cell.com/cell-host-micr… He also discusses characterising diversity in Wolbachia: bmcmicrobiol.biomedcentral.com/articles/10.11…

Dr Makepeace describes Wolbachia in immune evasion in the filarial nematode :royalsocietypublishing.org/doi/10.1098/rs… However, Wolbachia is not co-evolving with filariae in many cases (see Lefoulon 2020 paper above). #ParasitesOnline

Very interesting- Dr Makepeace now tells us about nanopore sequencing of cat flea Wolbachia species with or without prior culturing. Wolbachia is everywhere, including in bedbugs! A bit about the flea strains here: ncbi.nlm.nih.gov/pmc/articles/P… #ParasitesOnline @BSPparasitology

It should be noted that their are very different temperature sensitivities between Wolbachia strains which will need to be taken into account for Wolbachia-based mosquito-borne disease interventions: journals.plos.org/plospathogens/… #ParasitesOnline

Conclusion: the true diversity of Wolbachia is only just becoming apparent and no one mode of Wolbachia symbiosis dominates in filarial nematodes. #ParasitesOnline @BSPparasitology

Now to one of 3 #Trypanosoma talks during this #ParasitesOnline session: Dr Karinna Rubio-Peña of the @institutpasteur with "The role of VEX complex proteins in the insect to mammalian host transition of Trypanosoma brucei." #Parasitology

So keep an eye on the @Glover_Tryplab and look out for more work from Karinna Rubio-Peña in future if you want to see the effect of VEX1 on mVSG expression. More scRNAseq data in future as well! #ParasitesOnline

And the 2nd short #Trypanosoma talk at this #ParasitesOnline session is from Dr Sam Duncan over at @WCAIRDundee! He is telling us about "Investigating mitochondrial glycosylation in the African #Trypanosome." #Parasitology

It looks like, if we want to find out more about the role of Tb fucosyltransferase (TbFUT1) on #Trypanosoma growth etc., we'll have to just wait for a preprint! #ParasitesOnline @BSPparasitology

And the final #ParasitesOnline21 talk for today (before the evening's posters) is from Salome Aeschlimann at the University of Bern, with a talk about "p197 as the missing link between the outer mitochondrial membrane and the basal body in T. brucei." #Trypanosoma

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