Discover and read the best of Twitter Threads about #malaria

Most recents (24)

Today is #WorldMalariaDay.

#DYK: we can prevent and cure #Malaria?
Learn about the symptoms so you know when to get help from a healthcare professional bit.ly/3rF1djY
#Malaria is transmitted through the bites of Anopheles mosquitoes🦟
In 2020, nearly half of the world's population was at risk of malaria bit.ly/3rF1djY
Early diagnosis & treatment of #malaria reduces disease, prevents deaths and contributes to reducing transmission bit.ly/3rF1djY
Read 8 tweets
🧩Puzzle🦟 Pieces 🧩

Sars CoV2 & Malaria

SC2 spike protein shares gene sequence homologs with Malaria.
Both organisms invade red blood cells.
Both use TfR and CD44.
It might be interesting to compare microscopic images of RBCs in Malaria and Covid.
🩸Musical 🦟 Interlude🩸
I can hardly move
I can barely breathe
Near your features
#PuzzlePieces #Malaria #SarsCoV2 #SpikeProtein #Covid #LongCovid #SharedMechanisms
#PandemicPlaylist
What have we shown today?
SarsCoV2 spike protein shares gene sequence homologs with snake venom toxins🐍, SEB, HIV, Rabies, Malaria🦟 and several other organisms. It also shares similar pathophysiological mechanisms as these organisms. Some are exactly alike.>
Read 5 tweets
1/ 🧵Hello #medtwitter Ready for some NephMadness? 🤯
Not just any madness, but beware your mosquito bites 🦟, because today’s topic is #Malaria and kidney involvement.

#NephTwitter #NephMadness
@NephMadness
2/ 🧵 Where does the word malaria originate from?

PMID: 11053494
3/🧵 Malaria is an Italian word composed of “mala” and “aria,” meaning bad (malus) air (aeris). It was first used to describe a fever (miasma) mistakenly attributed to exposure to poisonous air.
PMID: 11053494, 9641206
Read 19 tweets
#disease risks in the new #IPCCReport

Climate change and variability are facilitating the spread of:
- #chikungunya virus in North, Central and South America, Europe and Asia
- tickborne #encephalitis in Europe
- #RiftValleyFever in Africa
- #WestNile fever in south- eastern Europe, western Asia, the Canadian Prairies, and parts of the USA
- #LymeDisease vectors in North America and Europe
- #Malaria in East and Southern Africa
- dengue globally
#Dengue risk will increase with longer seasons and wider geographic distribution in Asia, Europe, Central and South America and sub-Saharan Africa, potentially putting additional billions of people at risk by the end of the century
Read 5 tweets
𝟭𝟵𝟴𝟬:Wojciech “Al” Krotoski et al publish a report in the British Medical Journal describing a dormant liver stage of #Plasmodium cynomolgi in Rhesus macaques. These dormant liver stages, called "hypnozoites" are postulated to be the cause of relapses of this #malaria species Image
- Image references: ncbi.nlm.nih.gov/pmc/articles/P…; ajtmh.org/view/journals/…
- References: https://t.co/QDyaZSACDa; https://t.co/zzZPG6Ze3M; link.springer.com/article/10.100…
𝟭𝟵𝟴𝟭: In 1981, Dr William C. Campbell of the Merck Institute for Therapeutic Research in the US, published "An Introduction to the Avermectins" which described a new series of compounds with potent antiparasitic properties against nematode & arthropod #parasites. Image
Read 88 tweets
𝟭𝟵𝟳𝟯:In 1973, Thomas A. Miller of the University of Glasgow Vet School, had his canine hookworm (Ancylostoma caninum) vaccine approved for commerical use in the US. Though discontinued in 1975, Miller's work has informed hookworm vaccine research to this day! @BAVet_Parasitol Image
𝟭𝟵𝟳𝟰: In Oct '73, Dr Dan Jones of the Bascom Palmer Eye Institute in Miami introduced Acanthamoeba spp. as a human ocular pathogen to a meeting of the Ocular Microbiology & Immunology Group in the USA. Months later, in 1974, Nagington et al. would publish the 1st case studies Image
Read 9 tweets
𝟭𝟵𝟳𝟬: It was in 1970 that the full life cycle of #Toxoplasma gondii was described for the 1st time by Frenkel et al. Nowadays, the micro- and macro- gametocyte stages in the cat intestine are rarely studied, so the Frenkel et al. (1970) micrographs are still informative. Image
𝟭𝟵𝟳𝟭: A year that would forever change the field of #malaria research. In 1971, Prof Youyou Tu of the China Academy of Chinese Medical Sciences in Beijing, would use ether to extract "qinghaosu" from Artemisia annua L. leaf extract. In English: Artemisinin. @womeninmalaria Image
Read 7 tweets
In 𝟭𝟵𝟲𝟲, the eminent parasitologist P. Cyril C. Garnham published his "magnum opus", the 1132-page encyclopaedia of #malaria parasites, "Malaria Parasites and Other Haemosporidia". After 56 yrs, images from this book are still used as references across the world. #Plasmodium Image
𝟭𝟵𝟲𝟳- what a year! In 1967, Ruth Nussenzweig & colleagues released a @Nature paper showing that X-irradiated Plasmodium sporozoites produced protective immunity against #malaria in mice. This study sparked research that would result in the identification of CSP (1/3) Image
Read 11 tweets
Sehr schwer zu vermitteln, aber wichtig: *JEDE* #Impfung hat das Potential, eine Infektion komplett zu unterbinden– keine ist dabei perfekt. Extrem gut: #Masern-Impfung; nicht sonderlich gut u.a.: #Malaria, #Influenza, #COVID19. Abgesehen von kompletter… 1/3
…Verhinderung der Infektion („sterile Immunität“) schaffen es Impfungen aber, den zu zu erwartenden Verlauf der Krankheit abzumildern und abzukürzen. Dadurch bestenfalls auch verminderte Möglichkeit der Weitergabe (weniger Erregerlast, kürzere Dauer), aber auf jeden Fall… 2/3
…verminderte #Krankheitslast in einer geimpften Population. Wie wichtig das sein kann, siehe z.B. auch Diskussion um Malaria-Impfung ⬇️.

Schwarz-weiß ist in der Biologie fast nichts, aber auch ein Grau kann schon eine große Wirkung haben!

swr.de/wissen/wie-gut…
Read 3 tweets
Who's ready for another jab in March? Roll up your sleeve (again) for #Pfizer 1.1:

CEO Albert Bourla, Jan 10, 2022: "And we know that the 3, the 2-dose[s] of the #vaccine, offer very limited protection, if any."

#4IR #BiotechEconomy #GeneEditing #mRNA #Crispr

Thread 👇
Bourla con't: "The 3 doses w/ the #booster, they offer reasonable protection against hospitalization & deaths... Now, we are working on a new version of our vaccine, the 1.1 [] that will cover #Omicron as well."

Bourla: "... we are waiting to have the final results. The vaccine will be ready in March, & [] we'll be able to produce it massively."

Yahoo: "I want to quickly talk about the #kids... under 5... the company has said that it's going to need to be a 3-dose vaccine..."
#biotech
Read 6 tweets
"It’s a pleasure to welcome our friends from the Palais back to WHO.
The last time we hosted you, in July last year, none of us could have imagined that almost 18 months later, we would still be in the grip of the pandemic."-@DrTedros, media briefing for Geneva-based journalists
"More than 3.3 million people have lost their lives to #COVID19 this year – more deaths than from HIV, malaria and tuberculosis combined in 2020.
And still, COVID-19 continues to claim around 50,000 lives every week."-@DrTedros
"That’s not to mention the unreported deaths, and the millions of excess deaths caused by disruptions to essential health services."-@DrTedros
Read 41 tweets
#COVID19 pandemic has disrupted #malaria services, leading to a marked increase in cases and deaths: 14 million more cases in 2020 compared to 2019, and 69,000 more deaths - new report.
➡️bit.ly/3IlXxu9

#EndMalaria Image
Approximately 2 in 3 of these additional deaths were linked to disruptions in the provision of #malaria prevention, diagnosis and treatment during the pandemic bit.ly/3IlXxu9 #EndMalaria
Sub-Saharan Africa continues to carry the heaviest #malaria burden, accounting for about 95% of all malaria cases and 96% of all deaths in 2020.
About 80% of deaths in the region are among children under 5 years of age bit.ly/3IlXxu9 #EndMalaria Image
Read 4 tweets
#immunosuppression

IMMUNE CONTROL POINTS AND COVID-19

✅IMMUNOLOGIC CONTROL POINT MOLECULES ARE #INHIBITOR RECEPTORS EXPRESSED IN IMMUNE CELLS THAT TRIGGER IMMUNOSUPPRESSOR SIGNALING PATHWAYS.
These molecules are crucial to maintaining self-tolerance. 👉SIGNALING THROUGH THESE MOLECULES MAY TAKE IMMUNE EFFECT CELLS (ESPECIALLY T CELLS) TO A STATE KNOWN AS "DEPLETION". T cell depletion is defined by reduced effector function, poor memory responses
👉 due to sustained expression of immune checkpoint molecules (such as PD1, # CTLA4, # LAG3 ...). There are numerous types of activating and inhibitory interactions that occur between antigen presenting cells (APC) and T cells and thus regulate the nature of immunity.
Read 28 tweets
EN DIRECT avec @DrTedros: signature de l'Accord OMS-@OIFrancophonie twitter.com/i/broadcasts/1…
@DrTedros @OIFrancophonie "This agreement is the next step in strengthening the already-close relationship between our two organizations, building on the Memorandum of Understanding we signed in April"-@DrTedros
@DrTedros @OIFrancophonie "The #COVID19 pandemic has highlighted the importance of global solidarity and international collaboration. The @OIFrancophonie's commitment to peace, democracy and human rights makes it an ideal partner for WHO"-@DrTedros
Read 11 tweets
#idboardreview A patient returned 10 days ago from one of his monthly visits to Indonesia. +fever and headache. dx? #medEd #idmeded #IDTwitter Image
characteristic band trophozoite found in both Plasmodium malariae & #Plasmodium #knowlesi seen in Southeast Asia #malaria Ref GWIDBR
Read 3 tweets
#idboardreview can you identify this malarial species? Image
trophozoite of #Plasmodium #ovale #Schuffner’s dots & ovoid shape.
P. ovale #malaria is clinically similar to P. vivax & like P. vivax has a latent phase in liver from which relapse can occur.
Interval to relapse is P.ovale can be months or up to years later.
Ref GW IDBR
Read 3 tweets
@DrTedros @WorldHealthSmt "That first @WorldHealthSmt, in 2009, was held in the immediate aftermath of the global financial crisis, and in the shadow of the H1N1 pandemic. In the 12 years since then, the World Health Summit has become a landmark on the global health calendar"-@DrTedros #WHS2021
@DrTedros @WorldHealthSmt "That’s why, together with Professor Axel Pries, we have decided to join forces to organize a joint @WorldHealthSmt in October 2022, to engage an even broader group of actors, committed to multilateral action for global health"-@DrTedros #WHS2021
Read 32 tweets
1) An uninformed, pharisaical condemnation of an industry providing, w/regularity, life-saving, less invasive medical options at huge R&D cost:
2) The tweeter has a campaign against #Pharma, an imperfect industry, as all human endeavors are. She blames Pharma for poor nations, though it has provided millions of free doses. It escapes her that graft often frustrates the administration of those helps. We are blessed...
3) ...in our nation to enjoy market freedoms in which to exercise and profit from our industry and invention. We elect Gov't to hold business accountable and citizens who can organize and sue both. I won't broadbrush a grim picture of an industry that, though imperfectly,...
Read 15 tweets
A child dies from #malaria every two minutes.
One death is one too many.

🚨 Today, WHO recommends RTS,S, a groundbreaking malaria vaccine, to reduce child illness & deaths in areas with moderate and high malaria transmission bit.ly/3iEa4hd

#VaccinesWork
Over 800K children have so far received the RTS,S #malaria vaccine & are benefiting from this additional protection against malaria.
The vaccine significantly reduces malaria & life-threatening severe cases and could save tens of thousands of young lives each year.
#VaccinesWork
RTS,S #malaria vaccine was introduced in a pilot programme two years ago.
Since then, more than 2.3 million doses of the vaccine have been administered across Ghana, Kenya and Malawi bit.ly/3iEa4hd

#VaccinesWork
Read 4 tweets
LIVE: Media briefing with @DrTedros on #malaria vaccine recommendations. #EndMalaria twitter.com/i/broadcasts/1…
@DrTedros "As some of you may know, I started my career as a #malaria researcher, and I longed for the day that we would have an effective vaccine against this ancient and terrible disease. Today is that day; an historic day"-@DrTedros #EndMalaria
@DrTedros "𝐓𝐨𝐝𝐚𝐲, 𝐖𝐇𝐎 𝐢𝐬 𝐫𝐞𝐜𝐨𝐦𝐦𝐞𝐧𝐝𝐢𝐧𝐠 𝐭𝐡𝐞 𝐛𝐫𝐨𝐚𝐝 𝐮𝐬𝐞 𝐨𝐟 𝐭𝐡𝐞 🌍’𝐬 𝐟𝐢𝐫𝐬𝐭 #𝐦𝐚𝐥𝐚𝐫𝐢𝐚 𝐯𝐚𝐜𝐜𝐢𝐧𝐞.

This recommendation is based on results from an ongoing pilot programme in 🇬🇭, 🇰🇪 & 🇲🇼 that has reached 800K+ children since 2019"-
@DrTedros
Read 15 tweets
Pres of the Council of Ministers Italy "The advances we have made are at risk b/c of #COVID19 - #Italy is committed thru @g20org to "rekindle the spirit" that led to the creation of the @GlobalFund" "Sufficient, sustainable and predictable funding needed." HEAR HEAR
@oumajoyce2 speaking now: "I am humbled that Global Fund continues to engage and put us as civil society at the centre of the response - as we celebrate #GlobalFund20 I celebrate the 44 mn lives saved - amazing progress."
To learn more about @oumajoyce2 and her story and why she supports the @GlobalFund
globalfundadvocatesnetwork.org/2021-2022-spea…
Read 24 tweets
@GlobalFund 2021 #ResultsReport: A reader’s guide

#COVID19 is the headline, but there is a lot more to talk about, especially with the #7thReplenishment coming up.
theglobalfund.org/media/11304/co…
a 🧵...
#TB is front and center, because it was worst hit by #COVID19. Resources in pulmonary health diverted from TB towards Covid19 – doctors, beds, GeneXpert machines and cartridges – on top of everything else.
🧵
#HIV was impacted too, especially #prevention and #testing. #Malaria fared better, probably in part because countries with endemic malaria were hit by #COVID19 latter, though testing did drop.
🧵
Read 14 tweets

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