I don’t get the vitamin k thing. There is no known benefit (pubmed.ncbi.nlm.nih.gov/23080365/). And the harm is that It sends mixed signals. It undoes the teaching about the #cirrhosis coagulopathy. Because iv vit k is special and novel, it’s a consult rec that sticks. Needs reconsidering
For my #livertwitter friends replying about vit K deficiency in malnutrition, I am not mad at ya, I have nothing but love for you! I see - and address - malnutrition in every patient I meet! I am pro-food, pro-vitamin! I am happy we can still talk this out
WHY are steroids used for alcoholic hepatitis?
SHOULD we?
WHAT is the deal with prednisolone vs prednisone?
WHERE did the discriminant function come from?
ARE you ready for a #tweetorial
Alcoholic hepatitis is a life-threatening acute liver injury featuring a liver full of necrotic cells, "Mallory bodies" of cellular junk, & severe inflammation (neutrophils)
Fig1: Mallory's original description
Fig2: Alc hep Mortality in 1966 according to bilirubin
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Where did we get the idea for steroids in alc hep?
Everyone in 1950's France was using steroids to treat #cirrhosis. As in the examples below, Prednisone/prednisolone were said to resolve ascites, edema, jaundice, and fevers. They made patients hungry and happy too
Every year in the US alone, >50,000 acetaminophen overdoses are reported to poison centers, causing >110 deaths. Overdose can be intentional, though often accidental, always tragic.
There's an antidote: NAC. It saves lives.
Want to know how it was discovered?
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In the 1970's, Drs. Laurie Prescott & Roger Williams showed people were dying of APAP overdose in the UK
Then Mitchell et al released 6 papers showing why & what to do. Their 1st paper confirmed APAP dosing was key & showed that liver injury was due to p450 metabolism
We wanted to⬆️engagement with @JHepatology research
🤔Hypothesis: people are ⬆️ likely to connect with the people behind the research than the research itself
🧐Plan: Randomize papers to personal story tweets or graphical abstracts
🧐Primary Outcome: paper downloads #livertwitter
We found that story tweets garnered more downloads and tweet impressions
We conclude that showcasing the authors and their motivations in paired tweets is an effective strategy for research engagement
There is still more work to be done in optimizing the way a journal's account presents its research on twitter. We hope you enjoy our contribution. @kidney_boy@tony_breu@LizzieAbyMD@rrosenblattmd
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Wrong: You'll have "all the resources you need"
What are these? Stats, research cores, coordinator pools...
These are...people!
You cant promise a person!
Right: Meet X, 25% of their effort will be directed towards your work if you gel. Or here is $$$ to hire Y.
3/ Wrong: we expect you to do research, quality, etc
Right: we will support your research for X years
The week is 10 1/2 day sessions. Anything not clinical needs protection. 7 sessions is 30% protected. I was protected 3 years by the dept
Then I needed a grant for protection
It’s an enzyme that transfers amino acids to proteins. It's found anywhere things need transferring (liver cells, bile ducts, kidneys, heart....)
No big deal, right?
Wrong!
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It did not take long to figure out that while lots of conditions raised the GGT, liver disease and biliary obstruction were the best at making high GGT