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Shima Ghavimi Profile picture
@ShimaghavimiMD
Jul 14, 2021 • 14 tweets • 40 min read • Read on X
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#APC #TumorBoardTuesday #GITwitter #LiverTwitter #PrecisionMedicine #ColonCancer #oncology @ASCO @TumorBoardTues @CCAlliance @GeneticsSociety #Genetics #Genomics
Many of the mutations happen in the MCR region, WE should investigate the Armadillo Repeats regions for therapeutics Image
#BRAF #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues #Genomics Image
#KRAS #oncology #Genomics @GeneticsSociety @ASCO @FightCRC @TumorBoardTues #GITwitter #LiverTwitter #MedEd #Genomics Image
#MSH3 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA Image
#MMSH6 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety #Genomics @TumorBoardTues @CCAlliance @OfficialPCA Image
#NRAS #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @curecc @CCA_Alliance #Genomics Image
#TGFBR2 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA Image
#PIK3CA #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics Image
#SOX9 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics #obgyntwitter
Mutations in SOX9, the gene responsible for Campomelic dysplasia and autosomal sex reversal Image
#P53 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics #Genetics
The p53 gene is a type of tumor suppressor gene. Also called TP53 gene and tumor protein p53 gene Image
#TCF7L2 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics #Genetics
TCF7L2 is a Wnt signaling-associated transcription factor. Image
#SMAD4 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics #Genetics
The SMAD4 protein serves both as a transcription factor and as a tumor suppressor Image
#FBXW7 #PrecisionMedicine #Genomics #TumorBoardTuesday #GITwitter #LiverTwitter #MedEd #oncology @ASCO @GeneticsSociety @TumorBoardTues @CCAlliance @OfficialPCA #Genomics #Genetics
FBXW7 functions as a ubiquitin ligase tagging multiple dominant oncogenic proteins. Image
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More from @ShimaghavimiMD

Shima Ghavimi Profile picture
May 1, 2022
Intestinal Ultrasound
#GITwitter #MedEd

We will start with normal Normal #IUS #anatomy superficial mucosa (white) ...
#IBDtwitter

In ileocecal #Crohn’s disease, typically all bowel wall layers are involved. #IUS shows marked mural thickening, predominantly in the terminal ileum, cecum & appendix can also be involved.

🔗: ncbi.nlm.nih.gov/pmc/articles/P… Image
Bowel wall thickening is most prominent in the hyperechoic submucosal layer, representing deposition of fat and fibrous tissue as a result of chronic bowel inflammation Image
Read 56 tweets
Shima Ghavimi Profile picture
Jul 31, 2021
Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model #GITwitter
#PrecisionMedicine

gastrojournal.org/article/S0016-…
frontiersin.org/articles/10.33…
molecular-cancer.biomedcentral.com/articles/10.11…
Read 10 tweets
Shima Ghavimi Profile picture
Jul 29, 2021
UECN is likely an important mechanism in development of aneuploid tumors and could be therapeutically targetable.

nature.com/articles/s4158…
Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

nature.com/articles/s4158…
nature.com/articles/s4146…
Read 5 tweets

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