Discover and read the best of Twitter Threads about #Genomics

Most recents (20)

A break from #SARSCoV2 to another challenge—very early diagnosis of #cancer. Just released @ScienceMagazine is a study of 10,000 women using a blood test (#genomics, proteins) and PET imaging w/ very high specificity of diagnosis (and low sensitivity)
science.sciencemag.org/content/early/…
As far as I know, this is the 1st prospective study to show very early diagnosis of #cancer in healthy people w/o symptoms and curative potential. For that it is groundbreaking. The authors acknowledge many limitations and the further work to be done
While a blood test + PET for very early #cancer detection in a large cohort healthy women was a highlight of the day, a hard look at the numbers are warranted. Especially false positives. @jocelynkaiser @ScienceMagazine reviews the caveats here sciencemag.org/news/2020/04/b…
Read 3 tweets
🚨🧬🦠Great News! Just received approval to provide @QIAGENBiox CLC #Genomics ProSuite for free to any and all #publichealth or clinical microbiology labs who are sequencing or doing #bioinformatics of #SARSCOV2, the #coronavirus that causes #COVID19. Read this thread for details
Everything that follows is UNOFFICIAL. However, it will be captured on a specific landing page on QIAGEN Digital Insights that will go live with on Friday. In the meantime, I wanted to get the message out ASAP.
Tons of labs globally are already using CLC for microbial genomics work, including SARSCOV2 bioinformatics analysis. To support these labs, and those that may not have CLC already, we will be providing a collection of resources to help them with their work. This will include...
Read 16 tweets
I read the @biorxivpreprint every day. I've recently been asked by various people what/why/how I read so here is a short thread that may be helpful to others: 1/
@biorxivpreprint I read abstracts of articles on the @biorxivpreprint every morning and every evening, and typically a few times during the day as well. I am sometimes delving into the main paper, usually starting with the supplement. 2/
@biorxivpreprint I search for articles on @Google using keywords (and filtering for "past 24 hours"), my lab has @SlackHQ channels where people post articles, I check @rxivist, and I read and search twitter by keywords for topics I'm interested in every day. I follow @biorxivpreprint. 3/
Read 25 tweets
A single day & the pivotal role of single-cell sequencing:
1. Olfactory cells
@NatureNeuro nature.com/articles/s4159…
2. Organoids @naturemethods
3. Intra-tumor heterogeneity @NatureCancer nature.com/articles/s4301…
4. Sepsis
@NatureMedicine
5. Gut #microbiome @NatImmunol
Read 3 tweets
Cataloguing #Cancer: The day after #WorldCancerDay2020, @nature @naturepub publishes 22 papers w/ majorl new insights from whole genome sequencing. The cover & my v brief summary of the papers; also @NatureGenet @NatureComms @NatureBiotech @nresearchnews
nature.com/collections/af…
@nature @Naturepub @NatureGenet @NatureComms @NatureBiotech @nresearchnews "The future of cancer #genomics lies in the clinic"
An even better summary of these papers and the requisite next steps in the @nature editorial nature.com/articles/d4158…
Read 6 tweets
We are excited to share our pub in #EvolutionaryApplications bit.ly/2GH3tzr comparing relatedness estimates for pairing recommendations in critically #endangered #birds from #Aotearoa #NZ 🇳🇿. See this #SciComm 🧵 for more! #Conservation #Genomics #ConGen #ConSERTeam 1/13
Around the 🌏, #conservation breeding programmes strategically pair the least related individuals to enhance recovery. This is like #Tinder for threatened species, only more information goes into pairing than swiping ⬅️ or ➡️. See my #3MT for more! 2/13

It’s important to get the relatedness value right for pairing, because mating between close relatives can result in negative fitness consequences, like ⬇️ hatching success 🐣(see bit.ly/3b4IILO). 3/13
Read 13 tweets
If you are interested in analyzing #SingleCell #RNAseq data in #Bioconductor using #rstats, please check out our paper Orchestrating single-cell analysis (OSCA) with @Bioconductor that was published in @naturemethods this week! #genomics #scRNAseq #dataviz #methodsmatter
@Bioconductor @naturemethods OSCA is a rich, reproducible, accessible (from beginners to experts!) resource with many #scRNAseq workflows & datasets. The resource is an online #bookdown book that compiles every night to track development by the open-source and open-development @Bioconductor #rstats community
@Bioconductor @naturemethods Now, OSCA is not the only set of packages / workflows for the analysis of #scRNAseq data. #Scanpy (scanpy.readthedocs.io/en/stable/) and #Seurat (satijalab.org/seurat/) and are two incredibly popular packages in #python and #rstats, respectively.
Read 9 tweets
Our work is now officially out in @MolBioEvol: #Malaria viewed through the lens of an eradicated European strain tinyurl.com/qkqmaxe. (1/7) #published #genomics
On our hunt for past malaria we were fortunate to obtain a collection of blood-stained medical #microscope #slides prepared for diagnostics purposes in 1944 in Spain, one of the last footholds of #malaria in Europe. (2/7)
From these slides, and with a bit of lab wizardry from the team @uni_copenhagen @IBE_Barcelona, we were able to obtain a full #Pvivax genome - we also obtained a #Pfalciparum partial genome tinyurl.com/y2wsljcj. (3/7)
Read 7 tweets
National DNA Day:

🧬April 25

🧬Commemorates the day in 1953 when Watson, Crick, Wilkins, Franklin and colleagues published papers in the journal @nature on the structure of DNA

🧬Also commemorates the completion of the Human Genome Project in April 2003, took 13 years

#DNADay
DNA Double Helix:

🧬The two #DNA strands are reverse-complements

🧬Reading one strand in #reverse order and exchanging each base with its #complement gives the other strand

🧬A and T are complements, C and G are complements

DNA Sequence: AGTAGCAT
Reverse-Complement: ATGCTACT
In #Each DNA Strand:

🧬Pull the #DNA double helix apart, leaving the two single DNA strands

🧬The population (or occurrence) of every DNA sequence in that single-strand is #equivalent to the population of its reverse-complement DNA sequence in that same single-strand

#Genomics
Read 5 tweets
Data Needs A Home:

🧬The population of every DNA word is equivalent to the population of its reverse-complement DNA word in the SINGLE-STRANDED human genome

🧬Population count of 1.4 trillion DNA words

🧬Does anyone want a copy of this data before files are deleted?

#Genomics
Can You Use This #Data?

🧬Demonstrates the inherent inversion symmetry structure for all DNA elements in the single-stranded genome

🧬Demonstrates the absence of analog symmetries between reverse pairs and complement pairs of DNA elements

#BigData
🔂

👉cell.com/iscience/fullt…
Do You Know Anyone 🏷 Who Can Use This Data?

🧬The number of times every #DNA element (1-nt to 20-nt) occurs in the single-stranded genome

🧬This inversion symmetry structure is also maintained at the level of each individual #chromosome, except chromosome M (mitochondrial DNA)
Read 6 tweets
This is a thread on the list of #technologies #Nigeria should start taking seriously if she has the ambition of becoming number 1 in #Africa and maybe among the top 30 countries in the world as we enter the 4th Industrial Revolution.
#Industry40 #stem #tech 1/7
1. Mobile Internet fifth-generation (5G)
2. Artificial Intelligence (#ai), machine learning (#ml), deep learning (#dl)
3. Virtual and Augmented reality (#vr,#ar)
4. Cloud technology (#cloud)
5. Internet of Things (#iot)
6. Advanced robotics (#robots)
7. Biometric technology

2/7
8. 3D printing
9. Smart Spaces: Smart Cities (#SmartCities), Smart Homes (#smarthomes)
10. Blockchain (#blockchain)
11. Quantum computing
12. Autonomous things: fully autonomous vehicles
13. Nanotechnology (#nanotechnology )

3/7
Read 7 tweets
Well so this is an interesting thread and since it touches on #biotech I did want to mention a few things 1/
First, the value of "making the world a better place" that @Noahpinion mentions is right on the money. Everyone I've met in biopharma is dedicated to this idea and yes, it's likely many are making less than they could elsewhere. 2/
And, it's an amazing time in biopharma! Cellular therapies of various sorts, Gene editing, CRISPR, #genomics--holy cow are there exciting things going on! BUT...3/
Read 11 tweets
A reflection back on the #NHS review (topol.hee.nhs.uk) and some differences between #US and #UK #healthcare:
1. The #1 source of jobs in both countries is from healthcare, which continues to rise with a steep slope (mostly non-physicians)
The #US now spends more than $11,000 per person for healthcare, while the #UK ~$4,000. Yet life expectancy has declined in the #US for each of the past 3 years, while it continues to increase in the #UK (graph adopted from @OurWorldInData)
3. The @commonwealthfnd ranks the #UK first and the #US last of 11 countries overall, with differences in 5 sub-categories charted here
commonwealthfund.org/press-release/…
Read 11 tweets
Now reading the the #TopolReview report - Preparing the healthcare workforce to deliver the digital future. It's an illuminating read topol.hee.nhs.uk #DigitalHealth
It's clear that a lot of effort has gone into the #TopolReview - it paints a glorious vision of what healthcare would look like over the next 20 years (for both staff and patients) - enabled by technology such as #genomics, #AI and #robotics
For me the #Topolreview has too narrow a focus. It's been commissioned by healthcare, yet we know that with an aging population, many people with long term conditions have to rely upon #socialcare as well. We need joined up thinking, imho.
Read 34 tweets
High-Performance Medicine: my @NatureMedicine review of #AI and where we're headed nature.com/articles/s4159…
(open-access for 30 days)
The pervasive impact of #AI across all clinicians and throughout the lifespan
Eventually a virtual health coach will be built with extensive multi-modal inputs
Read 7 tweets
Has the brave new world of designer babies arrived? by @picardonhealth theglobeandmail.com/opinion/articl… via @GlobeDebate #CRISPR #bioethics #genomics
'Pandora’s box has been opened’: Scientist's baby gene-editing claim fuels backlash, by @KirstyLNeedham smh.com.au/world/asia/sci… via @smh @Kaubo #CRISPRbabies #genomics
Chinese scientist provokes furor with claim of world’s first genetically edited babies, by @nvanderklippe via @globeandmail #CRISPRbabies #genomics #bioethics
Read 14 tweets
Alright, #CSPC2018 @sciencepolicy, it's time to build some #HYPE!

Fuel up on ☕ & head up to panel #506 in the Capitale room at 3:30!

Great insights from panelists incl @tgruos @DSP_SPE & @MadisonRilling #CIÉ @SciChefQC and *news* (hype!) on the way for #nextgen in 🇨🇦 #scipol.
Here goes! Still time to join us #CSPC2018!
@BelislePipon @HarvardSciPol #FRQ introduces very first panel organized by #CIÉ @SciChefQC, w/ @BlakeFreier @tgruos @DSP_SPE @DLEKirkwood @MadisonRilling. Paul Dufour, as always, is our guide!

#CSPC2018 @sciencepolicy
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I was born & raised in #Medellin Colombia, an amazing & vibrant city in the middle of the mountains.

Please do not mention #Narcos or #Escobar when you hear Medellin!

Medellin is much more than that #eternalspring #innovation #Entrepreneurship #mountains #coffee #greatpeople
I was born & raised in #Medellin Colombia, an amazing & vibrant city in the middle of the mountains.

Please do not mention #Narcos or #Escobar when you hear Medellin!

Medellin is much more than that #eternalspring #innovation #Entrepreneurship #mountains #coffee #greatpeople
Went to a great school in #medellin & at 17 started #medicine not because I wanted to be a clinician but because I liked the #science & my family and #mentors told me #medicine was broader and could open more doors for me #VoicesIWS #Thread☝️@IWS_Network
Read 21 tweets
Starting "Voices without Frontiers" #VoicesIWS
A program by @IWS_Network to promote awareness about the challenges & lessons learned by #Immigrant and #International #WomenInScience

I was born & raised in Chicoral, Colombia. A tiny town in the middle of the Andes Cordillera.
I attended Nuestra Señora del Rosario school, located in Espinal, 15Km away from Chicoral. Due to the high heat by noon, all schools start really early back home. This meant, I had to wake up at 5am to attend school every morning since I was 4 years old. #VoicesIWS
I did well in math and science in elementary and high school, so I chose to study clinical microbiology. Although coming from a low-middle income family, I was able to attend university, thanks to my parents’ effort to prioritize education over other commodities. #VoicesIWS
Read 40 tweets
DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin:

1336 Datasets:

Defining NR Functional Enhancers (NRFEs)
#sNRFunctionalNRFE

Enhancer Activation
#IndicatorNRFE

sNR Cross-Talk
#sNRCrossTalkNRFE

doi.org/10.1210/en.201…
Functional Genomics:

📌Describes the relationship between an organism’s genotype (genetic makeup, DNA sequence) and phenotype (observable traits) on a global scale

📌A key characteristic is the genome-wide scale, rather than a more traditional “gene-by-gene” approach

#Genomics
DNA→RNA→Protein:

📌Genes:
-Blueprint for life
-Made of DNA
-Act as instructions to make proteins

📌Gene Expression:
DNA sequence is first copied to make an RNA molecule (transcription),
which is then "decoded" to build a protein (translation)

Proteins=Building Blocks Of Life
Read 8 tweets

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