The underlying problem isn't that the UK COVID-19 app is 'too sensitive.'
With a quarter-million cases & few restrictions, even if only correct contacts were pinged, that would be a huge number of alerts & isolations!
And yes - that's going to cause a lot of disruption 🤷🏻♀️
1/5
We're papering over the consequences of huge case numbers with debates around sensitivity.
Yes, we can turn sensitivity down - but # of alerts will continue to grow with cases - still potentially annoying people (who uninstall) & certainly continuing to cause disruption.
2/5
This isn't to say we shouldn't try to make pings more accurate, rather, that this isn't an actual solution to high number of pings right now.
Even if 30% pings were bad & we could get perfection now, UK cases rose 33% this week - so we are still at crazy high notifications.
3/5
Yes, there are legitimate debates to be had around who should isolate at all if the govt "strategy" is not to actively limit transmissions - but even with a fairly strict isolation definition, *with large case numbers will come large numbers of isolations & further cases.*
4/5
The higher the number of cases 📈
The harder it is to bring them down 😰
The greater increase in health risk 🏥
The more disruption from those isolating & ill 🤒
The more financial hardship follows 💸
The more confidence & ability to resume normal activities stalls🙅🏻🛍️🍲
5/5
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I've run preliminary @nextstrain focal builds on 20B/S:796H (B.1.1.318) (pictured) & 20A/S:210T (B.1.619).
These aren't part of CoVariants (yet?) but they've caught a couple eyes and I thought it was worth taking a closer look.
1/8
20B/S:796H (B.1.1.318) is behind most of the recent increase in 'other' variants circulating in Greece (shown in grey on the CoVariants plot, below - disregard last point, low sequence #'s).
It's very prominent in Greece, but also found worldwide.
Taking a closer look at Europe only, we can see there's a large cluster in Greece, but also distinct clusters in Switzerland & Ireland, & many sequences from other countries scattered between.
Also - we have awesome new flags on the Per Country page! 🏁🚩
Let's take a closer look...👀
1/10
21G (Lambda) was recently classified a VoI by @WHO & included in @nextstrain builds. It seems to originate in South America - we can see its prevalence in countries like Chile, Argentina, Ecuador, & Peru (purple-pink):
2/10
Looking at the focal build, we can see that 21G (Lambda) has also been found in North America, Europe, the Middle East, and Australia.
Lambda has a unique 7 AA deletion in Spike, & a mutation at S:L452Q.
S:417N has actually popped up multiple times in the Delta variant - it's of interest because it's thought to be related to immune escape & is also found in Beta.
But looking below, there are 2 main clusters - @PangoNetwork lineages AY.2 & AY.1
Last Sept, while looking for #SARSCoV2 sequences that could help us understand transmission across #Switzerland, I noticed a cluster that was present not just across Switzerland, but also the UK & Spain. This is the cluster that eventually came to be known as 20E (EU1).
2/24
EU1 had a mutation at position 222 in spike - this caught my eye.
From mid-summer 2020, EU1 (orange) expanded across Europe - becoming the most prevalent variant in most of Western Europe, & accounting for >30% of sequences in Europe by the end of 2020.