#Immunology General concepts:
1. A virus rampantly spreading will tend to mutate, and
2. 'natural selection' principles select the most transmissible strains that'll predominate.
3. Under a vaccinated population environment, the selection is towards a vaccine resistant strains!
1. A virus rampantly spreading will tend to mutate, and
2. 'natural selection' principles select the most transmissible strains that'll predominate.
3. Under a vaccinated population environment, the selection is towards a vaccine resistant strains!
The predominate strain will then be more transmissible, and develop vaccine resistance properties.
@pfizer and other vaccine scientists need to continue to sequence and test for the evolution of SARS-CoV-2 against transmissibility and vaccine resistance properties
@CDCDirector
@pfizer and other vaccine scientists need to continue to sequence and test for the evolution of SARS-CoV-2 against transmissibility and vaccine resistance properties
@CDCDirector
Staying ahead of this is vital.
Our ability to preempt such vaccine resistant viral strain emergence by modifying the mRNA coded in our current vaccine is crucial if we hope to avoid another more severe pandemic.
@EricTopol @PeterHotez @CDCgov
medrxiv.org/content/10.110…
Our ability to preempt such vaccine resistant viral strain emergence by modifying the mRNA coded in our current vaccine is crucial if we hope to avoid another more severe pandemic.
@EricTopol @PeterHotez @CDCgov
medrxiv.org/content/10.110…
As long as this virus is given the rich medium to rampantly spread and multiply, it WILL mutate & naturally select for the most transmissible strain AND mutate to defy the host's defenses. So eventually the vaccinated folks will encounter 'selected' strains that'll propagate!
The attached article is a window of what may come and what we must understand to model viral vaccine resistance and prepare a winning approach.
The unvaccinated are such rich medium for this variant which takes 3.71 days, vs alpha strain 5.61, to reach titers 1,260X that of alpha
The unvaccinated are such rich medium for this variant which takes 3.71 days, vs alpha strain 5.61, to reach titers 1,260X that of alpha
What will it take for you to get vaccinated?
It's novel, it's mutating and, as a result you're seeing perhaps from six months ago, you're seeing a very different strain or variant which might be more severe, so it’s important for people to get vaccinated right now.
It's novel, it's mutating and, as a result you're seeing perhaps from six months ago, you're seeing a very different strain or variant which might be more severe, so it’s important for people to get vaccinated right now.
The #DeltaVariant is so 'sticky' and comes at you with 1,260 times the viral load than the Alpha variant.
That means it enters your nose or airway (or even eyes) and hits you very hard
The vaccinated are protected against hospitalization
The unvaccinated are not
#GetVaccinated
That means it enters your nose or airway (or even eyes) and hits you very hard
The vaccinated are protected against hospitalization
The unvaccinated are not
#GetVaccinated
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