In excess dopamine itself can induce neurotoxicity, but its waste products cause more issues for the average individual
DOPAL, DOPAC, etc, accumulate in the nervous system after large burst of dopamine release, or longterm when glymphatic system function is impaired
DOPAL, DOPAC, etc, accumulate in the nervous system after large burst of dopamine release, or longterm when glymphatic system function is impaired
One of the essential roles of the glymphatic system is the clearance of neurotransmitter wastes during sleep by flushing out cerebrospinal fluid
One of the main reasons drugs like methamphetamine are so neurotoxic is the combination of high dopamine and impaired sleep
One of the main reasons drugs like methamphetamine are so neurotoxic is the combination of high dopamine and impaired sleep
I've even found a few reports of individuals with directly impaired glymphatic activity through tumor growth blocking CSF flow, which can cause rapid neurodegeneration
On a larger scale, sleep quality throughout life is one of the biggest determinants of brain health
On a larger scale, sleep quality throughout life is one of the biggest determinants of brain health
This process is regulated by melatonin, adenosine, GABA, and acetylcholine, and impaired by stimulatory neurotransmitters like glutamate and cortisol
Fix your circadian rhythm/light environment, and try magnesium glycinate and l-theanine before sleep
Fix your circadian rhythm/light environment, and try magnesium glycinate and l-theanine before sleep
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