The timing/extent of decline of hospitalisations suggests that the extent of decline we've seen in cases for the past 2 wks was likely real. Not sure how to square this with positivity, but hospitalisations are the real test & their extent/rate of decline tells us what happened🧵
I was more skeptical of case declines in children at the same time, because positivity had continued to rise even though cases were declining, suggesting undertesting/underreporting. But hosps in kids have peaked, which suggests these declines were real.
As many others have commented, it's likely a number of factors contributed - included the end of Euro2020s, >33% of children in secondaries being absent at the end of term, many Y11-13 being off post-exams, and many people isolating.
We know that in Scotland too, case declines began after Scotland dropped out of the Euro2020s, and schools closed and declines were sustained despite Scotland dropping to level 0 (of course still keeping mask and distancing mandates - so not fully comparable to England).
All of this suggests to me that schools and the Euro2020s likely played a major role in transmission. This is also clear from looking at incidence data with incidence >1000/100000/wk in secondary school children & young adults & a gap between case incidence in young men & women.
Understanding this is important, because this does suggest that we need to prepare for school openings in September, and also tells us about the risks of large events that lead to increased socialisation and activity that leads to superspreading.
While I'm incredibly grateful to see these declines, we should use this precious time to prepare for school openings & vaccinate adolescents, because if declines in school attendance & subsequent closures were partly responsible for this drop, they will reverse when schools open.

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More from @dgurdasani1

4 Aug
Dr. Lin at the JCVI outlining update of advice now in a briefing. They seem to be considering mostly direct benefits on children, and 'impacts of vaccine or other childhood vaccination programmes' like meningitis vaccination.Wish he would extrapolate- is this a capacity issue?🧵
Dr. Lin says it is rare for severe outcomes to occur. He talks about long COVID - saying this only occurs in 'a very small proportion' of long COVID. Wonder what data he bases this on, given the most unbiased and representative data suggest 8% incidence of symptoms for 12 wks.
He says vaccine benefits are greater for 'older children than younger children'. Is he referring to 16-17 yr olds vs 12-15 yr olds? Is he going to articulate what this difference is, and why vaccines aren't been extended to 12+
Read 17 tweets
4 Aug
While I'm grateful that JCVI are advising vaccinating all 16-17 yrs, this delay has been costly. We're still behind vaccine policy in other countries for 12-15 yr olds. Our preprint out today shows benefits far outweigh risks for 12-17 yr olds in England🧵
osf.io/grzma
The UK strategy is out of line with many other countries, including US, Israel, and much of Europe & SE Asia that have prioritised vaccination of all 12-17 yr olds. >9 million adolescents have been vaccinated in the US alone, and benefit vs risks have been quantified carefully.
Read 20 tweets
4 Aug
Rather disappointed by the reporting of what is a heavily flawed study in the media to suggest that long COVID is rare in children. There are many issues with this study that I'm sure long COVID researchers & patients will flag, but here's my analysis🧵
thelancet.com/journals/lanch…
1. Let's look at the context of the study. It's proxy reporting for children by parents through the Zoe symptom tracker. The study acknowledges that those using the app are more likely to be white & higher socio-economic status, both associated with reduced risk of poor outcomes
2. Even among those sampled and found to be PCR positive, only 24% appear to have had information deemed complete enough for analysis. Are those who were deemed to have more complete information logged likely to have been different from everyone using the app? Very possibly.
Read 24 tweets
30 Jul
Strongly recommend reading this doc from SAGE on virus evolution released today. Alongside several scenarios, it assesses the risk of variants emerging that lead to 'vaccine failure' as 'almost certain' & recommends controlling transmission to avert this. This is a stark warning. Image
We seem to be taking the very path that will get us to this devastating outcome. Given the impact delta has already had, & in light of recent evidence from the CDC, we cannot afford any more new variants emerging - we need to take preventive action now.

assets.publishing.service.gov.uk/government/upl…
And contrary to suggestions by some that SARS-CoV-2 is moving to becoming more benign (refuted by the fact that several more severe variants have already evolved and spread), it considers a move to more severe variants a 'realistic possibility' Image
Read 4 tweets
30 Jul
The PHE report released yesterday shows inconsistencies between case rates in England & positivity (the proportion of tests that are positive). This together with ONS data today suggests that at least some of the steep drops in cases we're seeing are down to less testing.🧵
First, let's compare case incidence to positivity rates. Case incidence depends on overall number of positive COVID-19 cases found each week. Positivity looks at proportion of tests that were positive. Case numbers will depend on background incidence & level of testing.
Positivity can help us when tests are declining, because cases found can come down when people aren't being tested for whatever reason. But positivity should remain high. The PHE report shows sharp declines in cases, but only very recent plateauing/slight decline of positivity.
Read 29 tweets
29 Jul
It's not revisionist, Francois. A lot of us pointed this out very much at the start- remember the John Snow Memo. While you were signing letters supporting a strategy of focused protection - a letter that stated cases would've declined in our 1st wave without lockdown anyway. 🧵
And there is no 'logistical support' that makes this viable as many of us pointed out & as this study shows. Vulnerable people are part of society. They live in households & form part of interconnected networks in society. You cannot protect them without containing the pandemic.
Maybe have the humility of accepting you promoted a flawed strategy, rather than attacking the people who challenged it rightly from the start (not in retrospect). Some self-reflection wouldn't go amiss here.
Read 4 tweets

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