Images of Infectious Diseases

A young man presents to the ER because of leg numbness. While undergoing evaluation, he had a seizure. CT head is shown (photo). #IDTwitter what is your differential diagnosis?

Case details #MayoIDQ MCQ to follow… Image
2/
36M migrant from Mexico
No PMH. HIV negative.
CC: leg numbness
ED: witnessed seizure
WBC 16. Cr 0.7. AST 35.
CT (photo)

Which one of the following is least likely the correct answer about this condition? #MayoIDQ
3/
Case diagnosis: #Neurocysticercosis NCC due to #Taenia #solium

There was an almost equal spread in the answers (probably due to poorly constructed MCQ :-) )

The least likely correct association is undercooked pork…. which leads to #taeniasis but not directly to NCC
4/
#Taeniasis vs. #cysticercosis depends on mode of acquisition.

Ingest cyst —> intestinal taeniasis
Ingest egg —> cysticercosis (including NCC)

Suggested MCQ answer:
undercooked pork —> leads to #Taeniasis and not #neurocysticercosis
5/
#Neurocysticercosis
Diagnostics

IDSA recommends serologic testing with enzyme-linked immunotransfer blot as a confirmatory test

Brain MRI and a noncontrast CT scan for classifying patients with neurocysticercosis
6/
Ocular cysticercosis is a form of extraparenchymal neurocysticercosis

Ophthalmologic examination is suggested in all patients with #neurocysticercosis to check for possible ocular cysticercosis.

Hyperinflmmatory reaction during anti parasite Rx could be sight threatening
7/
#Neurocysticecosis Rx

1–2 viable parenchymal cysticerci: albendazole monotherapy for 10–14 days

>2 viable parenchymal cysticerci: albendazole (15 mg/kg/day) combined with praziquantel (50 mg/kg/day) for 10–14 days (this was used in this case)

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More from @MayoClinicINFD

17 Jul
Weekend Digest

Name the pathogen and its treatment.

Clues:
1. Grows within protozoa
2. Decorative fountains
3. Hotel stay during travel
4. Cough + diarrhea
5. Antigen test
2/
#Legionella species

Aerobic “intracellular” GNB
>60 species

L. #pneumophila serogroup 1 - most common cause of human illness (water exposure)

L. #longbeachae (ANZ / soil, potting mix and compost exposure)
3/
#Legionella #pneumophila

Lakes. Streams. Reservoirs.

In water:
1. Planktonic
2. Biofilms
3. Intracellular in protozoa / free-living amoeba (protects bacteria from disinfection)
Read 9 tweets
3 Jun
Images of Infectious Diseases

42M on obinutuzumab for CLL. 4 mo ago: mild COVID-19 - no specific Rx. 3 mo ago: SARS-CoV-2 mRNA vaccine.

CC: 2 mo on/off fever, cough, dyspnea. NP SARS-CoV-2 PCR neg. Rx as CAP w doxycycline - no response.

CT chest. DDx? Work up? #MayoIDQ next Image
2/
Four months after mild COVID-19, an ICH man with CLL on obinutuzumab presents with prolonged / recurrent doxycycline-non responsive CAP. CT chest shown. See prior tweet for other details. Which of the following is the most likely diagnosis? #MayoIDQ
3/
All of the MCQ choices could be possible in this case. Imaging suggested viral or PJP.

Work up:
Serum BDG / GM negative
CMV PCR negative
BAL PJP PCR negative
BAL SARS-CoV-2 PCR +++
SARS-CoV-2 spike/nucleocapsid Ab negative (despite infection / vaccine)
Read 12 tweets
3 Apr
Weekend Digest

An Korean immigrant presented with early stage cholangiocarcinoma.

H & E stained tissue biopsy shown.

Name the pathogen and mechanism of infection.
2/
Case Diagnosis:
#Clonorchis sinensis - oriental liver fluke

“The eggs of Clonorchis are practically indistinguishable from those of #Opisthorchis” (photo credit: CDC)
3/
#Chlonorchis sinensis (and #Opistorchis)

Human infection is acquired by ingestion of undercooked, salted, pickled, or smoked freshwater fish (with metacercariae)

—> excyst in duodenum —> ascend biliary tree —> mature into adults in biliary ducts

cdc.gov/dpdx/clonorchi…
Read 7 tweets
1 Apr
Images of Infectious Diseases

This is middle turbinate of a 64 ICH with epistaxis s/p CAR-T for refractory diffuse large B cell lymphoma.

What is your DDx? #MayoIDQ next Image
64M refractory DLBCL
s/p CAR-T —> cytokine release syndrome Rx tocilizumab and steroids

CC: epistaxis x 2w
PE: lesion in hard palate; nasal endoscopy (photo). CT dense material in sinuses.

What is next best step?
3/
Biopsies from left hard palate and nasal cavity lesions were obtained (photo). Culture: Fusarium sp.

Suggested answer: ENT surgery for biopsy / diagnostics + debridement

Often: diagnostics and empiric Rx are concurrent in real life. Image
Read 4 tweets
23 Mar
Images of Infectious Diseases

H&E of brain biopsy specimen.

Who is the host? What is the most likely pathogen? How do you treat?
#MayoIDQ Image
2/ #MayoIDQ
75F. Immunocompetent.
CC: headache x few months —> now left leg weakness, blurred vision, seizure. CBC/CMP normal. CT head: mass in right ventricle, pons. CT chest/abdomen for CA work up (-). Brain biopsy (photo).

Which of the following is the most likely pathogen?
3/
Case diagnosis: cerebral #phaeohyphomycosis due to #cladophialophora

Note pigmented hyphae —> excludes Aspergillus (hyaline septate mould)

Among 3 remaining choices, the most common neurotrophic dematiaceous mould is Cladophialophora bantiana
Read 7 tweets
9 Mar
#MayoIDQ #IDBR
45M CC: tender mass on left thigh that started as an “insect bite” 4 days ago. No F/C. PE: tender fluctuant 2-cm mass with surrounding erythema.

After I&D of abscess in the clinic, what do you recommend?
2/
2014 IDSA guideline recommends incision and drainage of purulent SSTI (abscess)

Antibiotics vs MRSA / S. aureus as an adjunct to I&D if:
1. SIRS
2. Failed initial Ab Rx
3. Impaired host defense

Any new data since then?

doi.org/10.1093/cid/ci…
3/
After 2014 IDSA guideline, placebo-controlled RCTs were published on use of antibiotics (TMP SMX or clindamycin) for uncomplicated SSTI abscess ... (next)

ncbi.nlm.nih.gov/pmc/articles/P…
Read 5 tweets

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