An important critical review of a paper claiming cases of COVID19 occurred already in summer 2019 with a virus that based on all molecular analyses was a descendant of the original Wuhan virus. Contamination is a serieus possibility with use of the techniques described here
https://twitter.com/threadreaderapp/status/1424511400899121156
Agree to all that is mentioned in the thread. Also: these were said to be acute phase cases, as they were “ caught” by fever-and-rash surveillance, the way cases of measles and rubella are detected. In acute phase we really do not have any difficulty pulling complete genomes out
Rather than using nested PCR to amplify a fragment. Other point: the serology. Before completely changing what is currently known about SARScov 2 analyses, evidence needs to be robust. The serology used here could not be confirmed by neutralisation test for the early cases
That is worrisome. We have had that discussion with other data from the same region, claiming early circulation based on serology. journals.sagepub.com/doi/10.1177/03… we could not confirm any of the early cases with our stringent criteria. Does not mean nothing was there but not conclusive
Finding the origin of the pandemic is important and - based on current evidence- more likely was in Asia, probably China. The mission report did recommend highly standardized comparative studies in China and other areas with evidence of early circulation who.int/publications/i…
Still needed, urgently……
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