Shamez Ladhani Profile picture
Aug 12, 2021 11 tweets 4 min read Read on X
1/ Following a barrage of Twitter abuse because of my quote about our School Infection Survey (SIS) results today, I would like to reiterate what we have learnt about #COVID19 after 9 million students returned to full-time in-person education in England in March this year 👇
2/ The UK went into national lockdown including school closures in Jan 2021 following emergence of the Alpha variant. #COVID19 cases declined rapidly & schools reopened fully on 08 Mar 2021 (wk 10) when the rest of England remained in lockdown 👉 gov.uk/government/sta…
3/ During the 3 weeks until Easter holidays (wks 10-13, black circle), we saw a small ⬆️ in #covid19 cases among primary school kids (red line) & (because of mass rapid antigen testing before schools reopening) a large short-lived spike in secondary school kids (green) 👇
4/ Note, however, that the overall trend remained downwards including in the adult age-groups & remained *low & flat* for 6 whole weeks after the Easter break when all students returned to school while adults were in lockdown (blue circle). Cases did not ⬆️ in kids or adults 👇
5/ But look what happened when we moved into step 3 easing (17 May) of national lockdown (red circle). Cases started to ⬆️ in adults & kids, especially university-age (18-21y) & 20-29 yr-olds. Note the identical upward trajectory in secondary school students & 20-29 yr-olds 👇
6/ If this increase in cases after 17 May 2021 was school-related, then it should have started in April & cases should have transmitted to adult age groups in the household & in the local community, but we didn’t see any of that.
7/ And when you look at the national community infection survey (ONS CIS) which screens households across England, how can one explain such low infection rates in primary & secondary school students until 13 June, even after they were attending school full-time for >6 weeks?👇
8/ To me at least, the similar trajectory between secondary school students & 20-29 year-olds would suggested common contact & social behaviors outside school after 17 May when England started opening up, allowing youngsters more opportunities to meet & gather outside school
9/ Clearly, these data do not differentiate between in-school & outside-school transmission, but the published literature all point to limited [Not Zero, but low] in-school transmission, most likely because of the mitigations placed in schools [however well or poorly implemented]
10/ In conclusion, my reading of the data indicates that cases & outbreaks in schools reflect what is happening in the local community & with nearly all adults nearly double vaccinated, hopefully community infections rates will ⬇️ & that should help keep schools open more safely
10/ PS. Yes: we need more support for mitigations, including ventilation; No: I still haven’t seen convincing data on how much masks help ⬇️ school transmission; & No: we don’t need another adult lockdown to reopen schools because adults are now vaccinated (you know who you are)

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More from @ShamezLadhani

Jan 30, 2023
1/ Remember all the media coverage of #omicron causing so much severe #COVID19 in young kids?

We extended our @UKHSA #COVID19 deaths surveillance in kids & found:

ONE #COVID19 fatality per MILLION #Omicron infections in children aged <20 yrs …🧵

👉 sciencedirect.com/science/articl…
2/ We assessed all fatalities within 30 days of a positive #SARSCoV2 test in <20 year-olds during Jan-Mar 2022 when national testing was still available. We collected detailed clinical data from multiple sources to ascertain cause of death for each child
3/ During Jan-Mar 2022, there were 46 deaths within 30 days of a positive #SARSCoV2 test & 11 were due to COVID-19

👉All 11 #COVID19 deaths occurred after primary SARS-CoV-2 infection

👉 8/11 (73%) had underlying comorbidities, including 4 with severe neurodisabilities Image
Read 9 tweets
Dec 30, 2022
1/ This is so mportant - thank you @kerpen for tagging me

The US with all its mitigations, vaccine & booster mandates has the same proportion of kids already exposed to #sarscov2 as the UK, which as been accused of “letting the virus rip”

90.3% (US) vs 86.7% (UK)

…🧵
2/ In England, among 1-17 year-olds, we recently reported that by Sep 2022

➡️ 86.2% (95%CrL 81.1-91.6) had infection-induced #SARSCoV2 N antibodies

➡️ 97.2% (95% CrI 93.7%–98.9%) had #SARSCoV2 S-antibodies (infection and/or vaccine)

👉 journalofinfection.com/article/S0163-…
3/ According to US CDC, #SARSCoV2 antibody seroprevalence in 6m-17y by Sep-Oct 2022 was no different:

➡️ 90.3% (95%CI 89.8-90.8) had infection-induced N antibodies

➡️ 95.9% (95%CI 95.5-96.3) had S-antibodies (infection and/or vaccine)

👉 covid.cdc.gov/covid-data-tra…
Read 5 tweets
Dec 28, 2022
1/ Our @UKHSA paper on paediatric #SARSCoV2 antibody prevalence in England is now published

By Sep 2022, 97.2% of 1-17 year-olds had #SARSCoV2 antibodies

Our findings are critical for future #COVID19 vaccine/booster recommendations for kids

…🧵

👉sciencedirect.com/science/articl…
2/ Methods: We used residual samples from kids aged 1–17 years having a blood test as part of their clinical management in 44 hospital trusts in England. Samples were processed using Roche Elecsys assays for i) nucleocapsid (N) antibodies and ii) spike RBD (S) antibodies
3/ The overall national prevalence estimate of #SARSCoV2 antibody seropositivity in 1-17y, weighted by age & NHS region, based on Spike protein (vaccine or infection) increased from

➡️ 48.5% (95% CrI 40.8%–55.1%) during Sep-Oct 2021
to
➡️ 97.2% (95% CrI 93.7%–98.9%) by Sep 2022 Image
Read 8 tweets
Dec 5, 2022
1/ Our latest paper on longitudinal follow-up of teens with long covid (CLoCk) is a game changer:

Different teens report the same post-covid symptoms at 0, 6m & 12m after their #SARSCoV2 PCR , irrespective of whether they tested + or - for the virus

👉 sciencedirect.com/science/articl…
2/ Method: we followed up 11-17y with a PCR-positive #SARSCoV2 test compared with matched PCR-negative controls for 12 months after their test. The final cohort included 2,909 cases and 2,177 controls
3/ We found that teens reporting a symptom at baseline (PCR-testing) improved by 6m, with new teens reporting the same symptoms at 6m, who then improved by 12m, with new kids reporting the same symptoms at 12m and so on …. you catch the drift .. 👇
Read 9 tweets
Nov 18, 2022
1/ It’s really sad that, when we report that a disease (eg. #covid19) is more severe or fatal in kids with underlying conditions (eg neurodisabilities, immunocompromised), this is taken to mean that such kids are less valued

The truth is exactly the opposite…🧵
2/ It is really important that we identify kids at increased risk of severe outcomes after any condition (eg #COVID19) so we can raise awareness among clinicians, parents & policymakers to be extra vigilant & implement additional strategies protect them 👉journals.plos.org/plosmedicine/a…
3/ When kids with severe neurodisabilities were identified as high-risk in the 1st pandemic wave, the UK recommended #COVID19 vaccines for 12+y kids with severe neurodisabilities as soon as vaccines were licensed in adults - way back in Jan 2021 👉 adc.bmj.com/content/106/12…
Read 7 tweets
Nov 17, 2022
Remember that recent US paper on #covid19 vaccination for 5-11y?

We didn’t agree with the conclusions (h/t @ProfAsmaKhalil)

So, we wrote to @NEJM to explain why US data do NOT support BOOSTERS for kids irrespective of their previous infection status

👉 nejm.org/doi/full/10.10… Image
2/ We pointed out that there was very little difference in protection against omicron infection between vaccinated & previously infected 5-11y, while infection plus 2 vaccine doses might provide slightly better protection after 4 months (79.4% vs 62.9%)

👉nejm.org/doi/full/10.10…
3/ We then pointed out that #COVID19 hospitalizations were v low in 5-11y irrespective of vaccination status (0.3-0.5%), although we still aren’t sure how these were calculated because numerator/denominator in their table give lower percentages (0.1%)🤷🏻‍♂️

👉nejm.org/doi/suppl/10.1…
Read 6 tweets

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