In #longevity, if you mention SIRT1, people automatically go for their NAD+ (NR, NMR) supplements. Even though NAD+ and SIRT1 are joined at the hip [tinyurl.com/sjn6fzxu], having adequate NAD+ does not automatically translate into higher SIRT1 activity levels. Why not? [1/3]
SIRT1 is a cellular stress response modulator. As such, stress-induced pathways control SIRT1 expression [tinyurl.com/34sdks4b]. Interestingly, melatonin was shown to activate SIRT1 to dramatically increase activity levels in obese mice to match those of lean controls. [2/3]
MEL activation of SIRT1 protected mitochondrial pathways to reduce oxidative stress and inflammation, and also markedly reduced both body weight as well as systolic and diastolic pressure levels in obese mice given 100 mg/kg melatonin for 8 weeks. [3/3] tinyurl.com/2en9b9cu
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#cancer What if you can turn cancer cells into a 'Part-time' phenomenon, or even retire them altogether? A brilliant concept presented by Reiter and colleagues in their new peer-reviewed paper tells exactly how that can be achieved. tinyurl.com/5jdyrucf
1.Cancer cells use glucose as energy without involving electron transport in mitochondria for ATP. Instead, they use Warburg-type metabolisms that may use glycolysis and/or the pentose phosphate pathway to generate metabolites and substrates required for growth and proliferation
2. Recent discoveries show cancer cells can switch to using mitochondria OXPHOS similar to healthy cells for energy production. This switch apparently, can be mediated by the presence of higher melatonin that occurs naturally at night in most animals.
#Immunity from SARS-CoV-2 mRNA vaccination verses infection are distinctly different. C19 patients had augmented interferon responses & effector T/ B cells, while vaccine recipients had high circulating memory T & B cells without interferon response [tinyurl.com/yc3wxbtz].
(2) Viruses modulate host genomes to enhance their own survival and replication. This has been going on for billions of years where both DNA and RNA viruses can capitalize on epitranscriptomic modifications to maximize viral gene expression [tinyurl.com/7s6uj4um].
(3) Viruses have shaped and built the genomes of organisms to survive for billions of years. [tinyurl.com/3kbcjcdv]. In human history, viruses like EBV is known to reprogram host metabolism/gene expression to proliferate and increase pathogenicity [tinyurl.com/4r799jm5]