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Isaac Bogoch Profile picture
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27 Aug, 4 tweets, 2 min read
1/ Moderna's #COVID19 vaccine was approved for use in 12-17 year olds in Canada.

I am a firm believer in COVID-19 vaccines, including for this age cohort.

NACI has a statement that is worth reading.
1. Summary: bit.ly/3mFuERq
2. Whole Megillah: bit.ly/38q2KQJ
2/ Informed decision making is always key.

People need to know the benefits, risks, alternatives, & context when making a medical decision.

NACI describes a greater risk of myocarditis with Moderna vs Pfizer, typically in younger male cohorts. Most are mild & recover quickly.👇
3/ More info from the links above.

"The dose 2 reporting rates for all ages/genders combined were 28.2 and 8.7 per million doses administered for the Moderna vaccine and the Pfizer-BioNTech vaccine, respectively."

And this too👇
4/ Context is also important.

This virus is nasty, and can cause significant complications far in excess of what is seen with the vaccines.

Get vaccinated.

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Isaac Bogoch Profile picture
29 Aug
A few semi-related #COVID19 thoughts:

1. The virus isn't going anywhere any time soon

2. We will all be exposed at some point, maybe not today or this month, but in the next year or two

3. Must continue to⬆️the # of people with antibodies (from vaccination) prior to exposure👇
4. The pandemic is not over, even in countries with +++ vaccine access. Mitigation efforts are still needed to protect the vulnerable & unvaccinated (eg ineligible, those with barriers, etc) & to prevent overwhelming the healthcare system.

(The pandemic will end, just not yet)👇
5. We may need boosters at some point. Some (e.g. immunocompromised, etc) need these now. But we *ALL* don't need these now & should be supporting global vaccine efforts (COVAX).

6. Why not get a booster tailored to the "variant du jour" later on, when you actually need one?👇
Read 7 tweets
Isaac Bogoch Profile picture
18 Jul
1. ~80% of eligible Canadians have received a 1st dose of a #COVID19 vaccine & 2nd doses coming in fast. Nice!

2. This still leaves millions unvaccinated.

3. Delta (& all COVID) is +++ contagious, so no surprises when non-vax people get infected as measures lift (eg Europe).
👇 Image
4. While #COVID19 vaccines work extraordinarily well, there are enough unvaccinated folks who could get sick & require medical care.

5. Even if we see lower overall COVID-related healthcare usage due to significant vaccine uptake, we can't ignore pressure on healthcare system.👇
6. Think about healthcare capacity in Canada. Ontario had to essentially shut down to avoid overwhelming the healthcare system with ~600 patients admitted to ICUs with COVID-related illness. We ended up with 920.

7. This is in a province of ~14.5 million. That's a problem.
Read 7 tweets
Isaac Bogoch Profile picture
14 Jun
In an era where good news is in short supply, this analysis from Public Health England suggests that both Pfizer & AstraZeneca are highly effective against hospitalization with the Delta variant (after 2 doses):

1. Pfizer: 96%
2. AstraZeneca: 92%

Link: bit.ly/3iBSsn7
More details of the analysis can be found at this link, with effectiveness of Pfizer & AstraZeneca vs Alpha & Delta variants: bit.ly/3gv0uLX
Also, have a peek at the chart above & look at the effectiveness of a single dose for hospitalization....not too shabby.

This is very helpful data in support of Canada's 1st dose fast approach.

And now we are well underway for rapid follow up of 2nd doses. 🇨🇦
Read 4 tweets
Isaac Bogoch Profile picture
3 Jun
More emerging data from England regarding the Delta variant (B.1.617, initially discovered in India):

-It is more transmissible
-Appears to cause more significant illness

**Vaccines are still effective but 2 doses are ++ more protective than 1**

Link: bit.ly/3vPg2R4
The takeaways are pretty clear- we need to vaccinate quickly with smart 1&2 dose strategy focusing on vulnerable individuals & communities.

Unvaccinated & undervaccinated pockets (barriers to care, choice, etc) will be vulnerable and see spikes.

But polls show most🇨🇦to be vaxed
We are doing really well in much of Canada with the vaccine rollout, so if we play it smart with 1st and 2nd dose strategies, and continue vaccinating at a rapid pace we can avoid significant impact of this variant.
Read 4 tweets
Isaac Bogoch Profile picture
1 Jun
It looks like Canada's National Advisory Committee on Immunization (NACI) will give the green light to mixing & matching #COVID19 vaccines.

For example, those with a 1st dose of AstraZeneca may choose a 2nd dose of AZ or an mRNA vaccine.

bit.ly/3i7xkot by @adamsmiller
Mixing & matching #COVID19 vaccines may:

1. Provide more options to Canadians

2. Facilitate vaccine rollout if there are supply issues with a particular product

3. Possibly speed up rollout
Emerging data from the UK & Spain demonstrate the safety & positive immune response for mixing and matching.

France & Germany have been doing this for a while.

bit.ly/3p8VQXE
Read 4 tweets
Isaac Bogoch Profile picture
12 May
1/ A few #COVID19 vaccine updates for Ontario:

The province will receive 250K doses of AstraZeneca this month, likely reserved for 2nd doses.

Also, it is likely that those who received 1st dose of AZ *may* get a 2nd dose of an mRNA vaccine.

(Photography: Jay Kerr @bombippy)
2/ The push for vaccine equity by pouring vaccines into 114 heavily impacted postal codes was largely successful (to date), with a higher proportion of people receiving a 1st dose in those areas compared to other neighborhoods.

Good news, but the job isn't done.
3/ Pharmacies will massively expand their administration of mRNA vaccines (Pfizer/Moderna) with an aim to have ~2500 online (in all regions) vaccinating by the end of the month.

This will significantly push our vaccination rates higher & help with the rollout.
Read 6 tweets

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