Peer-reviewed. 1M+ sample size. A UK study on “breakthrough” infections shows individuals who tested positive for SARS-CoV-2 after 1 OR 2 doses of a vaccine had significantly LOWER odds of severe disease, hospitalization, OR developing Long COVID than unvaccinated individuals.🧵
Researchers found that the odds of having symptoms for 28 days or more after post-vaccination infection were approximately HALVED by having two doses of a vaccine. Their results suggest that the risk of Long COVID is reduced in individuals who are fully vaccinated, when
additionally considering the already documented REDUCED risk of infection overall. Vaccination (compared with no vaccination) was associated with reduced odds of hospitalization or having more than five symptoms in the first week of illness following the first or second dose,
and long-duration (≥28 days) symptoms following the second dose. Almost ALL symptoms were reported less frequently in infected vaccinated individuals than in infected unvaccinated individuals, and vaccinated participants were MORE likely to be completely asymptomatic, ESPECIALLY
if they were 60 years or older. For reference, the U.K. uses AstraZeneca, Pfizer, and Moderna and timing of the study does include the country’s spike in cases from the Delta variant. Find the study here: thelancet.com/journals/lanin…. Read more here: statnews.com/2021/09/01/vac…

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More from @sailorrooscout

16 Sep
A study out of the University of Edinburgh shows that vaccine efficacy against severe COVID-19 has NOT significantly decreased since Delta became the predominant variant, is around 92%, and does NOT differ significantly between AstraZeneca, Pfizer, and Moderna’s vaccines.🧵
In addition, efficacy against the broader category of hospitalized or fatal COVID-19 remains only SLIGHTLY lower for AstraZeneca’s vaccine than for the mRNA (Pfizer and Moderna) vaccines (88% versus 91%).
NOTE: The REACT-SCOT case-control study data extracted here INCLUDES cases presenting up to September 2nd, 2021, however the analyses reported here are restricted to cases and controls presenting FROM December 1st 2020 to August 19th 2021 (8 MONTHS).
Read 8 tweets
15 Sep
Yes, the vaccines ARE effective against the Delta variant. Yes, you will need both doses for maximum protection. Yes, they’re effective against preventing symptomatic infection, severe disease, AND hospitalization. Several studies have proven this now. Stop the misinformation.
Regarding the concerns about waning immunity. Please remember, this is likely referring to infection (see my most recent post on University of Pennsylvania’s study). Not effectiveness against symptomatic infection, not effectiveness against severe illness.
While neutralizing antibodies decrease over time (as they ARE supposed to) protective immunity provided by memory B-cells and T-cells is STILL present.
Read 8 tweets
15 Sep
Real-world data out of the Netherlands regarding vaccine effectiveness shows:

•Against Hospitalization: 95%
•Against ICU Admission: 97%

•Pfizer: 92%
•Moderna: 95%
•AstraZeneca: 93%
•Johnson & Johnson: 87%

Delta is currently the most prevalent variant in the Netherlands.
You can read more here: rivm.nl/sites/default/…
Data as of September 14th can be found here: rivm.nl/coronavirus-co….
Read 4 tweets
13 Sep
Real-world data out of Germany regarding vaccine effectiveness shows:

•Against Infection: 85%
•Against Hospitalization: 96%
•Against ICU Admission: 97%
•Against Death: 100%

Delta is currently the most prevalent variant in Germany.
For those 60 and older:
•Against Infection: 83%
•Against Hospitalization: 94%
•Against ICU Admission: 94%
•Against Death: 91%
Germany uses Pfizer, Moderna, AstraZeneca, and Johnson & Johnson COVID-19 vaccines. The vaccines are highly effective in preventing severe disease, hospitalization, and death due to COVID-19 even in the face of the Delta variant.
Read 4 tweets
8 Sep
Just HOW effective are the COVID-19 vaccines at protecting you from severe illness and hospitalization even in the face of Delta?

BEFORE Delta variant increase: 95% effective

DURING Delta variant increase: 92% effective

Answer: VERY EFFECTIVE

Let’s discuss. 🧵
Real-world data out of King County, WA (which includes Seattle) confirms vaccinated individuals are significantly better protected from illness, hospitalization, AND death due to COVID-19 compared to unvaccinated individuals, even as the Delta variant surges through the state.
Over the PAST 30 days, unvaccinated individuals were:
•7X more likely to test positive for COVID-19 (69% of cases)
•49X more likely to be hospitalized for COVID-19 (87% of hospitalizations)
•32X more likely to die of COVID-19 related illness (72% of deaths)
Read 14 tweets
3 Sep
A study out of the University of Illinois shows vaccinated individuals with a “breakthrough” infection are LESS likely to shed infectious virus at a given viral load, shed for a SHORTER period of time compared to unvaccinated individuals, AND report fewer days of symptoms.🧵
To shed light on how vaccine breakthrough infections compared with infections in immunologically naive individuals, researchers examined viral dynamics and infectious virus shedding through daily longitudinal sampling in a small cohort of adults infected with
SARS-CoV-2 at varying stages of vaccination (in this case mRNA & J&J). The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. Researchers also observed that breakthrough infections
Read 9 tweets

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