Tweet

Chise 🧬🧫🦠💉

16 Sep, 9 tweets, 3 min read

A study out of the University of Edinburgh shows that vaccine efficacy against severe COVID-19 has NOT significantly decreased since Delta became the predominant variant, is around 92%, and does NOT differ significantly between AstraZeneca, Pfizer, and Moderna’s vaccines.🧵

In addition, efficacy against the broader category of hospitalized or fatal COVID-19 remains only SLIGHTLY lower for AstraZeneca’s vaccine than for the mRNA (Pfizer and Moderna) vaccines (88% versus 91%).

NOTE: The REACT-SCOT case-control study data extracted here INCLUDES cases presenting up to September 2nd, 2021, however the analyses reported here are restricted to cases and controls presenting FROM December 1st 2020 to August 19th 2021 (8 MONTHS).

Researchers found efficacy of vaccination against severe COVID-19 decreased in May 2021 coinciding with the replacement of the B.1.1.7 (Alpha) by the B.1.617.2 (Delta) variant in Scotland, but this decrease was REVERSED over the next month.

In their most recent time window, the efficacy of two doses of vaccine against severe COVID-19 was 91% (95% CI 86% to 95%) for AstraZeneca’s vaccine and 92% (95% CI 85% to 95%) for mRNA (Pfizer or Moderna) vaccines.

Against the broader category of hospitalized or fatal COVID-19, efficacy in this time window was slightly lower: 88% (95% CI 85% to 90%) for AstraZeneca’s vaccine, and 91% (95% CI 88% to 93%) for mRNA vaccines.

Conclusion: These results are reassuring with respect to concerns that efficacy against severe COVID-19 might have fallen since the Delta variant became predominant. This weakens the rationale for policies based on delivering booster doses to the entire population, rather than to

vulnerable individuals for focused protection. You can find this study here: medrxiv.org/content/10.110… and read more here: thelancet.com/journals/lance… and FDA Says COVID-19 Vaccines Remain Effective Without Boosters: apple.news/AWz8KcUc7Qaubh…

To further support the points made in this thread, here is Dr. Jonathan Sterne's presentation from VRBPAC today that shows vaccine efficacy against severe COVID-19 has NOT significantly decreased since Delta became the predominant variant. Presentation: fda.gov/media/152241/d…

• • •

Missing some Tweet in this thread? You can try to force a refresh

This Thread may be Removed Anytime!

Twitter may remove this content at anytime! Save it as PDF for later use!

More from @sailorrooscout

Chise 🧬🧫🦠💉

@sailorrooscout

15 Sep

Yes, the vaccines ARE effective against the Delta variant. Yes, you will need both doses for maximum protection. Yes, they’re effective against preventing symptomatic infection, severe disease, AND hospitalization. Several studies have proven this now. Stop the misinformation.

Regarding the concerns about waning immunity. Please remember, this is likely referring to infection (see my most recent post on University of Pennsylvania’s study). Not effectiveness against symptomatic infection, not effectiveness against severe illness.

While neutralizing antibodies decrease over time (as they ARE supposed to) protective immunity provided by memory B-cells and T-cells is STILL present.

Read 8 tweets

Chise 🧬🧫🦠💉

@sailorrooscout

15 Sep

Real-world data out of the Netherlands regarding vaccine effectiveness shows:

•Against Hospitalization: 95%
•Against ICU Admission: 97%

•Pfizer: 92%
•Moderna: 95%
•AstraZeneca: 93%
•Johnson & Johnson: 87%

Delta is currently the most prevalent variant in the Netherlands.

You can read more here: rivm.nl/sites/default/…

Data as of September 14th can be found here: rivm.nl/coronavirus-co….

Read 4 tweets

Chise 🧬🧫🦠💉

@sailorrooscout

13 Sep

Real-world data out of Germany regarding vaccine effectiveness shows:

•Against Infection: 85%
•Against Hospitalization: 96%
•Against ICU Admission: 97%
•Against Death: 100%

Delta is currently the most prevalent variant in Germany.

For those 60 and older:
•Against Infection: 83%
•Against Hospitalization: 94%
•Against ICU Admission: 94%
•Against Death: 91%

Germany uses Pfizer, Moderna, AstraZeneca, and Johnson & Johnson COVID-19 vaccines. The vaccines are highly effective in preventing severe disease, hospitalization, and death due to COVID-19 even in the face of the Delta variant.

Read 4 tweets

Chise 🧬🧫🦠💉

@sailorrooscout

8 Sep

Just HOW effective are the COVID-19 vaccines at protecting you from severe illness and hospitalization even in the face of Delta?

BEFORE Delta variant increase: 95% effective

DURING Delta variant increase: 92% effective

Answer: VERY EFFECTIVE

Let’s discuss. 🧵

Real-world data out of King County, WA (which includes Seattle) confirms vaccinated individuals are significantly better protected from illness, hospitalization, AND death due to COVID-19 compared to unvaccinated individuals, even as the Delta variant surges through the state.

Over the PAST 30 days, unvaccinated individuals were:
•7X more likely to test positive for COVID-19 (69% of cases)
•49X more likely to be hospitalized for COVID-19 (87% of hospitalizations)
•32X more likely to die of COVID-19 related illness (72% of deaths)

Read 14 tweets

Chise 🧬🧫🦠💉

@sailorrooscout

3 Sep

A study out of the University of Illinois shows vaccinated individuals with a “breakthrough” infection are LESS likely to shed infectious virus at a given viral load, shed for a SHORTER period of time compared to unvaccinated individuals, AND report fewer days of symptoms.🧵

To shed light on how vaccine breakthrough infections compared with infections in immunologically naive individuals, researchers examined viral dynamics and infectious virus shedding through daily longitudinal sampling in a small cohort of adults infected with

SARS-CoV-2 at varying stages of vaccination (in this case mRNA & J&J). The durations of both infectious virus shedding and symptoms were significantly reduced in vaccinated individuals compared with unvaccinated individuals. Researchers also observed that breakthrough infections

Read 9 tweets

Chise 🧬🧫🦠💉

@sailorrooscout

2 Sep

Peer-reviewed. 1M+ sample size. A UK study on “breakthrough” infections shows individuals who tested positive for SARS-CoV-2 after 1 OR 2 doses of a vaccine had significantly LOWER odds of severe disease, hospitalization, OR developing Long COVID than unvaccinated individuals.🧵

Researchers found that the odds of having symptoms for 28 days or more after post-vaccination infection were approximately HALVED by having two doses of a vaccine. Their results suggest that the risk of Long COVID is reduced in individuals who are fully vaccinated, when

additionally considering the already documented REDUCED risk of infection overall. Vaccination (compared with no vaccination) was associated with reduced odds of hospitalization or having more than five symptoms in the first week of illness following the first or second dose,

Read 5 tweets

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Share this page!

Chise 🧬🧫🦠💉

Try unrolling a thread yourself!

More from @sailorrooscout

Chise 🧬🧫🦠💉

Chise 🧬🧫🦠💉

Chise 🧬🧫🦠💉

Chise 🧬🧫🦠💉

Chise 🧬🧫🦠💉

Chise 🧬🧫🦠💉

Did Thread Reader help you today?

Like this author's thread?