#Risk_Management Understand the Risks

Understanding the Risk.
1/ Risk is the possibility of losing money in an investment. We can manage risk in our investments once we understand what it is and what kinds of risk there is around investing. Often just understanding the
risks helps people better understand how they want to invest.
2/ I always use an expression of, “Manage the risks, and the rewards will take care of themselves”. I think I adapted this from something Warren Buffet once said. No truer words have been spoken. You can't make money unless you understand all the risks and how to mitigate them.
3/ You can't make money if you lose everything in one very speculative investment that fails.
4/ How much risk you are willing to take comes down to two factors. The first is your personal tolerance
for risk. Some people, like me, can put all their money in a bunch of risky speculative biotech companies and sleep like a baby.
5/ Other people get all nervous and can't sleep a wink if their portfolio goes even slightly into the red. I know a lot of people who say they can tolerate a ton of risk, but they freak out whenever something goes wrong with any of their companies.
6/ You got to honestly know how much risk you are comfortable with.
7/ You should never take any more risk than is necessary to achieve your long term goals. The market
averages 8% a year over the long term. If you need more than that to reach your retirement goals, then
you might need more risk.
8/ If you don't, then you can safely put your money into a low cost index fund and kick back. The amount of risk you want to assume depends on how much risk you can tolerate and how much risk you need to assume to meet your goals.
9/ The higher the risk you take in investing the
bigger the reward, but so is the bigger risk of losing all your money. I see so many investors focus only
on the rewards and never the risks.
10/ Market risk always exists. Corrections and crashes happen all the time in the market. They can come
from economic forces like a recession or geopolitical forces like an earthquake, pandemic or war.
11/ You can't control them, and you don't know when they are going to strike. In the market we call them the
Black Swan events. There are two main ways to protect yourself from the overall market risk.
12/ The first is you can hedge yourself. I have friends that sell covered calls or other options strategies to protect their investment in stocks from market risk.
13/ The other is just to raise cash into big rallies for the market and buy back positions into the big crash or correction. That is my strategy. I tend to fade the rallies slowly as the stocks move higher. Then I slowly buy back my positions into a sell-off.
14/ The other major risk is company specific risks. Anyone who has been in biotech for 5 seconds knows
these all too well. They often come in the form of clinical failures, but there are many types of
company risks.
15/ The biggest one is the risk of a poor management team. A poor management team can turn your investment life into a humbling experience. Taking a discovery stage biotech from start to commercial takes many important skills for a management team.
16/ Many of them are not up to that task. There are risks of patents, competition, obsolescence, failure to find funding, manufacturing and so many more.

• • •

Missing some Tweet in this thread? You can try to force a refresh
 

Keep Current with Biotech2k

Biotech2k Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Biotech2k1

15 Sep
#Cancer_Immunology TME

A look into the Tumor Micro Environment (TME).
1/ There is a complex set of interactions that must go on between a tumor and its surroundings. It has to interact with the tissue cells, it needs nutrients, it needs oxygen, it needs to survive and proliferate in a hostile environment.
2/ One of the many things it has to achieve to exist and thrive is to overcome the immune system and its natural ability to find, target and destroy tumors. There are 3 key cells in the immune system that are designed to find and kill cells that are infected or defective. Image
Read 19 tweets
15 Sep
My Game Plan:

Pathways:
$BPMC 3.37% core position
$MRTX 3.37% core position
$TPTX 3.37% core position
$SDGR 1.35%
$RVMD 2.7%
$RLAY 2.7%
$ERAS 0% considering but way too expensive
$RPTX 2.02%
$KNTE sold out as it was my weakest link
Protein Degraders:
$ARVN 1.35%
$KYMR 1.35% paying down a core position
$CCCC 2.02% paying down a core position
$GLUE 1.35% paying down a core position
CRISPR/Old Antibodies
$CRBU 1.35% paying down a core position
$BCAB 2.7% will sell out when I think its good opportunity.

CRISPR is way to crazy on values to waste money on here. It will implode someday, and I will be waiting.
Read 6 tweets
15 Sep
#Targeted_Protein_Degradation

A look into protein degraders.
1/ There are 2 types of protein degraders in development and a 3rd in concept phase of development. The first is the monoDAC, the second is the biDAC and the last is the triDAC.
2/ The monoDAC will bind with a covalent chemical bonding to the E3 ligase and alter its targeted function. It changes the shape of the E3 and directs it to place the ubiquitin molecule onto a protein it directs.
Read 7 tweets
15 Sep
#The_Proteasome

I look at how the Proteasome works.
1/ The Proteasome is a cellular organelle. Its like the recycling bin for proteins. When a cell is done with a protein, it tags it for destruction in the process called ubiquitination.
2/ The proteasome will load these tagged proteins and break them down into peptides of about 7 to 10 amino acids in length for recycling. They will further be broken down after into single amino acids for reuse to build new proteins.
Read 7 tweets
15 Sep
#Ubiquitination

A look at ubiquitination.
1/ Cells make, regulate and break down proteins constantly. They have a system to control the regulation of the proteins they produce. This is to remove unwanted proteins when no longer used.
2/ It also maintains healthy proteins as they degrade slowly over time. The process of ubiquitination is the tagging of these proteins by the cell for destruction. There are 3 enzymes that work in the process of ubiquitination.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!


This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!

:(