1/ The best investment in the world is the risk free investment. This comes by taking enough profits in a
company to take out your costs. Then you can keep it forever if you want. I call this playing with the
house's money.
2/ I get that question the most of any question I get from investors. It goes like this, “I bought XYZ company and it's up 300%, should I keep it or sell it?” My answer is always the same. I tell them to sell at least enough to take out their costs.
3/ Then they can let the rest run as long as they like
the company. This allows us to take out our cost when things are bubbly so we don't lose money during
the bust period.
4/ The one thing you can count on in biotech is there will be setbacks and struggles for every early stage company. Taking out your cost reduces your risk to zero.
5/ I tend to use a system of trading around my position to pay off my cost a little at a time. Once I reduce my cost basis to zero from capital gains, I can hold my shares at no risk to me.
6/ The biggest risk I have ever found in the markets is emotion. Things like fear and greed compel
investors to do all the wrong things for all the wrong reasons and at the very worst time.
7/ Things like buying an exciting new biotech at the peak of euphoria right before it crashes back to reality. Fear will compel investors to sell a great company just because the stock is going lower right before a big buyout.
8/ The first thing a successful investor learns to do is to control their emotions with strategy and discipline.
9/ I find my emotions actually work the opposite of most other investors. When stocks are screaming
higher, I get scared as I know those profits will be erased on the next correction.
10/ When stocks are crashing, I am like a kid in the candy store. I get excited by a good sell off. I love buying things that I like when they are cheap.
11/ Emotion has ruined many investors in my 25 years. Strategy and Discipline are the virtues of the investors who not only survive but thrive over the long term.
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1/ There is a complex set of interactions that must go on between a tumor and its surroundings. It has to interact with the tissue cells, it needs nutrients, it needs oxygen, it needs to survive and proliferate in a hostile environment.
2/ One of the many things it has to achieve to exist and thrive is to overcome the immune system and its natural ability to find, target and destroy tumors. There are 3 key cells in the immune system that are designed to find and kill cells that are infected or defective.
Pathways:
$BPMC 3.37% core position
$MRTX 3.37% core position
$TPTX 3.37% core position
$SDGR 1.35%
$RVMD 2.7%
$RLAY 2.7%
$ERAS 0% considering but way too expensive
$RPTX 2.02%
$KNTE sold out as it was my weakest link
Protein Degraders:
$ARVN 1.35%
$KYMR 1.35% paying down a core position
$CCCC 2.02% paying down a core position
$GLUE 1.35% paying down a core position
CRISPR/Old Antibodies
$CRBU 1.35% paying down a core position
$BCAB 2.7% will sell out when I think its good opportunity.
CRISPR is way to crazy on values to waste money on here. It will implode someday, and I will be waiting.
1/ There are 2 types of protein degraders in development and a 3rd in concept phase of development. The first is the monoDAC, the second is the biDAC and the last is the triDAC.
2/ The monoDAC will bind with a covalent chemical bonding to the E3 ligase and alter its targeted function. It changes the shape of the E3 and directs it to place the ubiquitin molecule onto a protein it directs.
1/ The Proteasome is a cellular organelle. Its like the recycling bin for proteins. When a cell is done with a protein, it tags it for destruction in the process called ubiquitination.
2/ The proteasome will load these tagged proteins and break them down into peptides of about 7 to 10 amino acids in length for recycling. They will further be broken down after into single amino acids for reuse to build new proteins.
1/ Cells make, regulate and break down proteins constantly. They have a system to control the regulation of the proteins they produce. This is to remove unwanted proteins when no longer used.
2/ It also maintains healthy proteins as they degrade slowly over time. The process of ubiquitination is the tagging of these proteins by the cell for destruction. There are 3 enzymes that work in the process of ubiquitination.