To get all the world to 40% requires 2 billion doses.
Projected global supply 1.5 billion doses.
But COVAX supply forecasts have fallen 25% because of booster programs in wealthy economies.
This is why WHO are calling for a moratorium on boosters. 1/n
Limited data on safety & efficacy of boosters.
No emergency approval by FDA / WHO etc.
WHO continue to monitor situation.
Based on data so far, their advice is that the global priority is to supply first doses to weaker economies.
Photo: nara.getarchive.net/media/us-army-… 2/x
Summarizing press briefing on boosters.
Low rates of COVID deaths with high vaccination.
High rates in countries with low doses.
COVAX downgraded supply 25%
Not asking to stop something with good evidence for need for boosters.
Vaccines performing very well against variants to stop severe disease and death.
Is a case for 1st priming dose for imunocompromised.
Hard to see any substantial benefit more than benefit of people receiving 1st dose.
Vaccines not authorized by regulators - in many places around the world not a scientific consensus.
Note the vaccine manufacturers are already testing new boosters targeted to variants (later 2021) and CEPI is funding 2nd & 3rd generation vaccines that may stop all possible variants also with much higher efficacy (some time 2022). See my debunkingdoomsday.quora.com/Easy-to-tweak-…
The moratorium is not about boosters targeted to variants or 2nd & 3rd gen vaccines. It's about a 3rd identical dose targeting the ancestral variant.
This is being rolled out in some countries based on limited data and divided scientific opinion on whether and how much it helps.
Also, not about a 3rd shot for severely immunocompromised. The WHO call that a 3rd priming shot, not a booster. There is good scientific evidence that this helps. bmj.com/content/374/bm…
For boosters, WHO are recommending we follow the science, updated as understanding develops.
Dr Tedros calls for batch swaps. 1. UK receives new batches as top priority from manufactures, while ours expire. 2. Many health workers in Africa not yet vaccinated. 3. If Africa gets our next batch we still have months of excess doses & get theirs later. who.int/director-gener…
Dr Bruce Aylward: it's very difficult to move doses from one country to another just before they expire.
Batches for COVAX can be allocated dynamically to any country ready to use them.
Batch swaps are far more effective than donating expiring doses.
Redone the graphic for Dr Mike Ryan's analogy to make it clear it is his analogy not mine. @DrMikeRyan
See earlier in this tweet thread for links to the press briefings etc.
Dr Mike Ryan 1st makes the analogy here:
@DrMikeRyan Oxford University Professor Sarah Gilbert, leading scientist behind the Astrazeneca vaccine agrees with WHO that boosters are best going to weaker economies. abcnews.go.com/Health/wireSto…
@DocLT2 Yes indeed. Many reinfections already, some within a few weeks. bnonews.com/index.php/2020…
Coronaviruses often reinfect. This shows infections of one individual by 4 coronaviruses from blood sample antibodies. Each black dot = inferred infection. nature.com/articles/s4159… 1/2
@DocLT2 This is steady state after centuries to 1000 years evolution without vaccines.
With COVID it's only just leapt to humans.
This was written just before alpha was detected. In last sentence, didn't expect variants to evade immunity so soon with COVID. nature.com/articles/s4159… 2/3
@DocLT2 It's very limited data for coronavirus colds - they surely are just as complex as COVID and more so but we barely see the tip of the iceberg of the complexity.
Interesting situation, Novavax is first vaccine sent to WHO for approval first - stronger economies saturated in vaccines, so, much less interest in developing new vaccines.
Novavax also very good at transfer of technology and first deliver of 100 million doses is to COVAX.
These are the four scenarios they look at.
SSP1-1.9: Zero emissions for 2050+, ~1.4 °C long term
SSP1-2.6: Zero for 2070+, ~1.8 °C
SSP2-4.5: Low emissions by 2100, ~2.9 °C
SSP2-7.0: Double emissions by 2100, ~3.6 °C
SSP2-8.6: Double emissions by 2050, ~4.4 °C
Westminster gov. failed to bring the virus under control & is now preparing to remove the last few remaining measures that inhibit it from spreading even more widely amongst our only partially vaccinated population.
International COVID experts respond:
Almost 50,000 cases per day
Only half fully vaccinated.
Expect many millions infected over summer.
UK gov. has chosen to do this even though we have effective vaccines.
We ask experts to respond
New Zealand: Always looked to UK for leadership
Remarkable depth of scientific knowledge.
Remarkable clinical trials we are drawing on.
Incredible development of vaccines & rollout.
Astounded you are doing this despite amazing expertise you have in UK.
Headlines about solar storm headed for Earth are fake news. There was an X-class flare that caused some over the horizon radio blackouts on July 3 - few people use long wave radio now.
Solar flares and solar storms do nothing to the internet (connected via optical fibre) or cell phones (connected via direct microwave transmission). They can cause short term glitches in GPS.
Once per century solar storms may cause powercuts, in particular places depending on local geology and lengths of power lines, indistinguishable from ones we get anyway - surges could affect old model step up down transformers or near end of their life.
The BBC tell us 1. exit wave is inevitable - FALSE 2. COVID is seasonal - during huge summer surge! 4. opening up now relieves pressure on the NHS in winter -higher estimates for summer hospitalization surge similar to H1N1 peak!
A mass of logical absurdities.
We are 50% unvaccinated. We need to finish that vaccination and also vaccinate down to adolescents - that's an extra 2 days for each year group at 400,000 doses a day. That gives far better immunity than natural infection and we are better prepared for the winter.
That's 2 days per age group for first dose then the same again 3 weeks later. Then we have masks, test trace isolate, physical distancing, ventilation, #DOITALL in ways that have no impact on economy as we open up carefully. Meanwhile by autumn we have vaccines that target delta.