@RWMaloneMD Doctor: I have been researching the S1 protein of the original SARS virus from early 2000s to see if it performed similar actions against human health as does the SARS-COV-2 S1 protein. The SARS spike was just as dangerous as it turns out.
"Recently, the renin–angiotensin system, an endocrine cascade best known for regulating blood pressure, has been implicated in the respiratory damage responsible for SARS lethality. Angiotensin II, which is produced through the action of angiotensin-converting enzyme (ACE),
"has been identified as a potent vasoconstrictor that
can aggravate lung injury and produce lung oedema.
"Intriguingly, in vitro experiments have indicated that ACE2 — a homologue of ACE that negatively regulates angiotensin II — is a cellular receptor for SARS-CoV.
can aggravate lung injury and produce lung oedema.
"Intriguingly, in vitro experiments have indicated that ACE2 — a homologue of ACE that negatively regulates angiotensin II — is a cellular receptor for SARS-CoV.
"Now, by using mice deficient for ACE2, Kuba et al. provide the first in vivo evidence for the importance of this enzyme in SARS-CoV replication, and show that
infection with SARS leads to downregulation of ACE2.
infection with SARS leads to downregulation of ACE2.
"The authors identified the SARS-CoV Spike protein as an interaction partner for ACE2, and demonstrated that recombinant Spike exacerbates acute lung injury through down-modulation of ACE2 and subsequent
accumulation of angiotensin II."---END QUOTE FROM THE NATURE ARTICLE."
accumulation of angiotensin II."---END QUOTE FROM THE NATURE ARTICLE."
So, as early as 2005, the danger of at least the SARS-COV-1 spike protein was known, including the interaction with the ACE2 receptor causing changes in gene expression of cells resulting in vascular and pulmonary disorders that could be fatal in nature.
Then in 2009 we see vaccine developers are obsessing with the spike protein of original SARS, SARS-COV-1 as it is now called. Now, I want to know how all this attention on the spike protein of original SARS had to be widely known and was documented yet your position is that...
...the developers of the SARS-COV-2 mRNA vaccines did not know the spike protein of SARS-COV-2 was dangerous as set forth in papers such as the SALK Institute produced last year.
A 2009 NATURE article discussing vaccine developer interest in original SARS spike protein.
nature.com/articles/nrmic…
nature.com/articles/nrmic…
@threadreaderapp I need this one for the collection. Please UNROLL. Many thanks.
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