Thread by @Farrier105

The History of Research into Corona Virus Spike Protein
2004--2020

We've been told that the researchers who came up with the mRNA vaccines for COVID-19 did not realize the spike protein was a danger to humans in its own right, separate from the virus.

In the next breath, the same researchers say that the spike protein of the SARS-COV-2 virus was not the one used for the mRNA vaccines, so, if it wasn't the same, was the spike protein used NOT dangerous since it isn't the same one as on the virus itself? The dangerous...

...spike protein IS the one on the virus itself and was the inspiration for the name of the family of virus being "Coronavirus," since the spikes resemble a crown and "corona" is Spanish for "crown."

The fact that it is the spike protein on the virus itself that was designated a potential threat to humans is found in recent articles in these these scientific journals

The Salk Institute:

salk.edu/news-release/t…

The Drug Target Review:

drugtargetreview.com/news/90224/gen…

Of course, if a different spike protein was used, and that cited for ignoring these research findings, then why does anyone say "We made a mistake using the spike protein because we didn't know it was dangerous." It is possible that WE are supposed to conclude that the spike...

...protein from the virus is not dangerous if it was NOT the one used in the vaccine. No one says that so far. The just say it was different. Well, that is not what we were told from the very beginning. We were told is WAS the spike protein from the virus.

Pfizer told us that:

pfizer.com/news/hot-topic…

"How does an mRNA vaccine work?
mRNA, delivered to your body's cells by lipid nanoparticles, instructs the cells to generate the spike protein *found on the surface of the novel coronavirus* that initiates infection."--Above Pfizer Web site.

We were told that what was used was only part of the spike protein from the virus. Well, in the case of Pfizer, we have this from the following journal:

JOURNAL OF BIOMEDICAL SCIENCE
December 20, 2020

The JOURNAL of BIOMEDICAL SCIENCE traced the history of the attempts to find a vaccine for coronaviruses since original SARS in 2003. Interestingly, starting with original SARS, the spike protein (S Protein) was THE part of the virus researchers first noticed.

"There are also immunopathological complications associated with the SARS-CoV and MERS-CoV vaccines that require addressing and further optimization. One adverse effect is the induction of antibody-dependent enhancement (ADE) effect...

"... which is usually caused by vaccine-induced suboptimal antibodies that facilitates viral entry into host cells."

"Additionally, two studies have also shown that anti-S protein serum results in increased viral infectivity of SARS-CoV [33, 34].

"These results raise safety concerns for S protein-based SARS-CoV and MERS-CoV vaccines."

The article goes on to describe how researchers found that using just one part of the Spike protein (S Protein) might reduce Antibody Dependent Enhancement (ADE).

These problems were first found with original SARS in the early 2000s. So, the virologists and immunologists were all very intrigued by the use of the S Protein in a vaccine to trigger immune response. They even found one danger in using the entire S Protein, ADE.

So, how did they miss all the other ones, such as SALK Institute finding COVID-19 is a VASCULAR disease, not a respiratory disease, and how spike protein can change gene expression in cells with ACE2 receptors?

Original SARS was a respiratory disease. It has a spike protein like the lowly common cold coronaviruses. We don't hear about coronaviruses that cause common colds causing changes in gene expression, such as a blood cell mass producing platelets until there's a clot.

So, the spike proteins of orginal SARS and the corona common colds can't do all those things. Suddenly we have a coronavirus, that can do all those things. There are only a few ways this could have happened. Everyone knows what those are, or should know...

...,but we don't know which caused the change, whether natural or unnatural. We do know that when scientists were trying to identify this novel virus, the PCR came up with a microbe that was less than 80% of the genome of original SARS.

So, are today's vaccines the full length spike protein or just a piece of it, and if it is just a piece of it, is THAT PIECE DANGEROUS?

Well, we have this from the JOURNAL OF BIOMEDICINE article from December 2020:

"Up to now, BioNTech and Pfizer have published two BNT162b1 phase I/II trial results that were conducted in Germany (NCT04380701) and the US (NCT04368728), respectively [144, 145].

"Following these two papers, they also published another study comparing the vaccination responses between BNT162b1 and BNT162b2 [146].

'BNT162b1 encodes a trimerized RBD of spike protein while BNT162b2 encodes a full-length spike protein [143]." RBD means Receptor Binding Domain of the S Protein was used to trigger immune response. BNT162b1 only used part of the S Protein. BNT162b2 used all the S Protein.

BNT162b2 went on to the third trial.

BNT162b1 and BNT162b2 were shown to induce similar neutralizing titers in younger and older adults [146]. However, BNT162b2 had less systemic reactogenicity in older adults [146].

"Therefore, they decided to move forward with BNT162b2 instead of BNT162b1 into a phase III clinical trial (NCT04368728)."

The result of the third phase of the trial was that BNT162b2 was 95% effective against COVID-19, which was the report we received just as FDA approved Emergency Use Authorization. BNT162b2 used the full length spike protein.

Not only do we need answers about the S-Protein used, but we also need to understand something about what we were originally told about the nature of the S Protein used in the vaccines and how this relates to the appearance of VARIANTS to SARS-COV-2 virus.

The vaccines use the spike protein as the TRIGGER to the immune response the vaccine is used to create. The theory behind this was, the vaccine trains the immune system to attack the spike protein, and in that way attack the virus itself.

We also know that our immune system can be compromised in its ability to fight a virus if the virus mutates, hence the concern about VARIANTS. However, these vaccines only created immune response to the PRESENCE OF THE SPIKE PROTEIN, not the entire virus.

The only way the Variants could foil the vaccine would be if the SPIKE PROTEIN WAS WHAT BECAME A VARIANT, and not some other part of the virus. Thus far, none of our public health officials have offered any details about the spike protein being so different that the immune...

response, created by the vaccine, can no longer work against the new version of SARS-COV-2. Since it is at least highly apparent that Pfizer used the entire spike protein, a whole lot would have to change about the protein to throw off the immune response.

And we have a problem when reconsidering whether or not the entire spike protein from the virus was used, or whether part of it was used, or whether a "different" protein was used in the vaccines in relation to the variants. If even a slight difference in the spike protein...

...could hinder immunity from the vaccine in regards to a VARIANT, how could anyone use anything other than the entire spike protein from the virus OR part of the actual protein from the virus, as the trigger for the immune response from the vaccine?

These are all just questions based upon what we have been told from the beginning, and on the fact that SARS viruses in general have garnered much attention in all their aspects since the turn of this century. Hopefully, the answers will come soon.

@threadreaderapp I really need this one for future use. Please unroll.