Been Working on my Science Categories:

Pathways 20% max
Synthetic Lethality 15% max
CRISPR 15% max
Protein Degraders 15% max
Cell Therapies 15% max
Delivery 15% max
Max 95% with 5% cash
I think come out to a good diversification. It would never get that low on cash as I plan a few transitions. I am splitting up Pathways and Synthetic Lethality which is kind of a judgement call since they highly overlap.
Pathways:
1 $BPMC max 5% = 3.3%
2. $TPTX max 5% = 3.3%
3. $RVMD max 3% = 2%
4. $ERAS max 3% = .67%
5. $RLAY max 3% = 2%
Max 19%
Synthetic Lethality:
1. $MRTX max 5% = 3.3%
2. $SDGR max 3% = 1.35%
3. $RPTX max 3% = 2%
Max 11%
CRISPR:
1. $NTLA max 3% = 0% above $125
2. $CRSP max 3% = 0% above $100
3. $BEAM max 3% = 0% above $83
4. $CRBU max 3% = 2%
Max 12%
Cell Therapies:
1. $FATE max 3% = 0% above $50
2. $SANA max 3% = 1.35%
3. $IPSC max 3% = 1.35%
4. $TIL max 3% = 1.35%
5. $CABA max 3% = 1.35%
Max 15%
Delivery:
1. $GBIO reduce to 0% = 2.7%
2. $FDMT reduce to 0% = 2%
Max reduce to 0%
This is just where I would like to go. Many of these companies I don't own as they are grossly overvalued. Some I would fade as the sector continues to go higher as its so over value for the $XBI in general.

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More from @Biotech2k1

26 Sep
#Viral_Capsids

A look at viral capsids.
1/ The capsid is a strong protein structure that encloses and protects the viral genome. The most basic viruses will use a single protein produced many times to build the capsid. The more complex viruses will use multiple proteins to build their capsid structure. Image
2/ The basic structure of the viral capsid comes in 3 basic designs. They are Icosahedral, Helical and Complex.
Read 18 tweets
25 Sep
#Viral_Genomes

A look at the Baltimore scale for viral genomes.
1/ There are over 21 families of viruses. Each of these families will have many strains of viruses within them. Just the Herpes virus has 8 different strains within its family. Others like Flavivirus has strains like Dengue, Zika, West Nile and Yellow Fever.
2/ Other then classifying viruses by their family, we can classify them by their genetic makeup. There are 7 different classes of viral genomes. They are classified using the Baltimore scale shown below.
Read 20 tweets
25 Sep
Here are my Watch Lists:

These are the companies on my lists for when the bubble pops in biotech. Most of them are grossly overvalued, but awesome companies.
Pathways:

1. $BPMC - fair value
2. $MRTX - expensive
3. $TPTX - fair value
4. $SDGR - very expensive
5. $RVMD - very expensive
6. $ERAS - very expensive
7. $RLAY - bubbly
8. $RPTX - very expensive
Protein Degraders:

1. $ARVN - bubbly
2. $KYMR - bubbly
3. $CCCC - bubbly
4. $GLUE - very expensive
Read 7 tweets
24 Sep
#Cell_Therapies iPSC

A look at induced Pluripotent Stem Cells.
1/ This has been a huge love of mine for years. The engineering of cells to create cancer therapies. The induced Pluripotent Stem Cells (iPSC) can revolutionize the way we create CAR-T or CAR-NK cells for cancer treatments.
2/ The process of the iPSC can be automated, duplicated and consistent as a source of low cost cell therapies. So how does this work?
Read 15 tweets
24 Sep
My Exit Strategy Updated:

Not at my trading laptop so all are estimates. I plan to fade all rallies in biotech back to old high as value for the $XBI is only $112.
Pathways:

$BPMC 3.34% will keep my 2.02% paid core
$MRTX 3.34% will keep my 2.02% paid core
$TPTX 3.34% will keep my 2.02% paid core
$SDGR sell all
$RVMD sell all
$ERAS sell all
$RLAY sell all
$RTPX sell all
Protein Degraders:

$ARVN sell all
$KYMR 1.35% will keep my .67% core
$CCCC 1.35% will keep my .67% core
$GLUE 2.02% will keep my .67% core
Read 8 tweets
22 Sep
#Molecular_Glue

A look at how molecular glue works.
1/ In previous Targeted Protein Degrader threads, I went over the basic process of how the E1 enzyme adds the phosphate group to the ubiquitin molecule. It then passes it to the E2 enzyme which binds to the E3 ligase as a complex.
2/ The E3 ligase is designed with a site of recognition that is specific to a group of proteins. These proteins, called substrates, can be many different proteins for the same E3 ligase, but they all have a specific site that the E3 recognizes and binds to.
Read 6 tweets

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