Syringaresinol from Japanese Plums, like Resveratrol, activates the longevity enzyme SIRT1. New study confirms its benefits are due to a mimicry of fasting 🥗 tinyurl.com/3vnh36wz
Thanks @agingdoc1 for the heads up
This molecule is interesting. It prevents cellular senescence (formation of zombie cells 🧟‍♀️), boosts antioxidant defenses, suppresses enzymes that promote skin aging, and in 🐁 with excess oxidative damage, reverses skin aging 8 weeks #beauty tinyurl.com/rwh4rf2z
FYI, how resveratrol & other xenohormetic molecules activate SIRT1 is here. Such an elegant mechanism 👀
nature.com/articles/ncomm…
science.sciencemag.org/content/339/61…

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More from @davidasinclair

15 May 20
One third of homes have a cat. There are 600M globally. A study @NEJM confirms cats spread #coronavirus to each other & may spread it between family members. I’m concerned it could mix with a fatal cat coronavirus... 1/n
Some say “Well, the virus has not been proven to spread from cat to human.” As @StevenAustad has pointed out, this hasn’t been tested or disproven either. It is like saying in December 2019 that a virus in China hasn’t been proven to spread to the US. 2/n
Is no one but me concerned about viral genetic mixing & a new strain emerging from cats? Cats have their own #coronaviruses. They can cause one of the most fatal cat diseases known by destroying white blood cells (HIV-like). 3/n
Read 10 tweets
14 May 20
1/ Let me start by saying that this was a fantastic piece on vaccine development by @stuartathompson at @NYTimes.
2/ Having started a now public company that makes vaccines (thanks to my cofounder Darren Higgins and to @gatesfoundation), I can tell you many people don't appreciate just how long it takes to develop a drug.
3/ Vaccines often take longer. Of every drug that is picked to go into humans, less than 5% will ultimately be approved. Luckily, the outbreaks of SARS and MERS in 2004 and 2012 have given us a head start (SARS and SARS-CoV-2 are ~80 percent identical).
Read 7 tweets
14 May 20
Outlook for this decade: POOR
1. 85% of economic impact is caused by fear of the virus not by stay-at-home. 2. WHO says the virus may never leave, like HIV. If true, we are in serious trouble. 1/n
Let’s not ignore the likelihood that survivors “will be left with chronic kidney & heart problems”, something the pro-herd immunity folks don’t consider. If you think spending 17% of US GDP on healthcare is bad now...2/n
We have also seen that leadership matters. NZ & Australia stopped movement, enforced it & tested and traced asymptomatics. They couldn’t even buy a coffee & are now essentially covid-free. US & Britain waited, let people travel & didn’t test & trace. We see the consequences. 3/n
Read 6 tweets
11 May 20
Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? tinyurl.com/yapwdy87 1/n
The result is so literally incredible that even the first author, Prof. Steve Horvath, didn't believe it at first. I suggested he check if the rats were mixed up, but he assured me he checked their genomes. The rats weren't mixed up and the data is the data. 2/n
Being from a commercial operation called Nugenics (sounds like eugenics?) and calling the blood plasma fraction "Elixir" doesn't inspire confidence. But let's dig in...3/n
Read 24 tweets
10 May 20
The Festival of Dangerous Ideas live streaming now. Dr. @normanswan and I chat live at 10EST tonight, midday AEST. Free to all. festivalofdangerousideas.com ✌️ #fodi #aging #health
Will check if it’s recorded and report back.
Yep, I’ve confirmed it’s recorded and will be uploaded to YouTube. I will provide the links. Get some sleep 😴
Read 5 tweets
9 May 20
Important! Largest study yet on #Covid_19 fatality shows top risks:
1. Age, BY FAR the highest
2. Cancers of the blood
3. Male
4. Obesity
5. Diabetes
I will say it again: Aging is a disease & it is treatable. Yes, treatable. 1/n #healthcare tinyurl.com/yahsd3vq @bengoldacre
Striking finding: smoking makes little difference to #Covid_19 fatality, so it can’t explain bias in male deaths (What can? Hint: males age faster). 2/n
For smoking, error bar on the hazard ratio chart is close to zero, so smoking is probably not protective either, as some have speculated. tinyurl.com/y8l2qpom 3/n
Read 6 tweets

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