1/ Booster Doses - 9/12 later
Worth it? Rationale?
With global vaccine inequity - should we feel guilty?
Why I chose to mix...
Also co-incidentally this is my Halloween costume:
"Government Agent"
"Big Pharma Shill"
Take your pick.
Some thoughts ahead.
#COVID19BC
#BCPoli
Worth it? Rationale?
With global vaccine inequity - should we feel guilty?
Why I chose to mix...
Also co-incidentally this is my Halloween costume:
"Government Agent"
"Big Pharma Shill"
Take your pick.
Some thoughts ahead.
#COVID19BC
#BCPoli
2/ Why Now?
First dose Dec 20 & second dose Jan 31st.
At the time we weren't sure what optimal dosing interval was & had ongoing supply issues, so many got 2 doses at varying shorter intervals.
Now we know ~12 weeks is a good interval, but also are seeing waning immunity.
First dose Dec 20 & second dose Jan 31st.
At the time we weren't sure what optimal dosing interval was & had ongoing supply issues, so many got 2 doses at varying shorter intervals.
Now we know ~12 weeks is a good interval, but also are seeing waning immunity.
3/ Waning Immunity
Data is showing our antibody levels to #COVID19 are decreasing, but that doesn't mean our overall immunity is, as we are seeing by our vaccine effectiveness data in BC.
But, in BC we still are losing too many ppl, almost 50 have passed in last week.
Data is showing our antibody levels to #COVID19 are decreasing, but that doesn't mean our overall immunity is, as we are seeing by our vaccine effectiveness data in BC.
But, in BC we still are losing too many ppl, almost 50 have passed in last week.
4/ What data do we have on boosters?
More to come for sure, but Pfizer released data last week, RCT of 10,000 ppl that showed post booster
"relative vaccine efficacy of 95.6% against disease during a period when Delta was the prevalent strain"
pfizer.com/news/press-rel…
More to come for sure, but Pfizer released data last week, RCT of 10,000 ppl that showed post booster
"relative vaccine efficacy of 95.6% against disease during a period when Delta was the prevalent strain"
pfizer.com/news/press-rel…
5/ How long will boosters last?
Don't know yet, but based on vaccine science we can expect that a booster like this may induce longer term immunity as we have seen in Hepatitis B, Diphtheria, Tetanus, Pertussis, Polio, & Haemophilus influenzae type b Vaccines etc.
Don't know yet, but based on vaccine science we can expect that a booster like this may induce longer term immunity as we have seen in Hepatitis B, Diphtheria, Tetanus, Pertussis, Polio, & Haemophilus influenzae type b Vaccines etc.
6/ How can we in good conscience get our booster when many in the world haven't gotten first?
We know the world is suffering, but as HCW we have a responsibility to make sure we're keeping our patients safe, so as our authorities recommend it, we will get it to do our part.
We know the world is suffering, but as HCW we have a responsibility to make sure we're keeping our patients safe, so as our authorities recommend it, we will get it to do our part.
7/ Canada - COVAX contribution
Canada made more commitments at G20 today.
"In all, between financial contributions and direct delivery of doses, Canada says it will help deliver at least 200 million shots of vaccine by the end of next year."
globalnews.ca/news/8337703/c…
Canada made more commitments at G20 today.
"In all, between financial contributions and direct delivery of doses, Canada says it will help deliver at least 200 million shots of vaccine by the end of next year."
globalnews.ca/news/8337703/c…
8/ WHO Statement on Boosters
"Introducing booster doses should be firmly evidence-driven and targeted to the population groups in greatest need. The rationale for implementing booster doses should be guided by evidence on waning vaccine effectiveness..."
who.int/news/item/04-1…
"Introducing booster doses should be firmly evidence-driven and targeted to the population groups in greatest need. The rationale for implementing booster doses should be guided by evidence on waning vaccine effectiveness..."
who.int/news/item/04-1…
9/ BC Boosters
Our program is proactive & most ppl will be getting boosted in 2022 (6-8 months post 2nd dose).
The boosters now will be targeted for people who there is higher risk of waning immunity or are in higher risk situations.
I believe the spirit is concordant.
Our program is proactive & most ppl will be getting boosted in 2022 (6-8 months post 2nd dose).
The boosters now will be targeted for people who there is higher risk of waning immunity or are in higher risk situations.
I believe the spirit is concordant.
10/ Why Moderna?
I got Pfizer for my first 2 doses, and decided to Modernaize my approach (was given the option w/ thanks).
Some data is emerging showing mixing booster may boost antibody response w/ similar side effect profile & no safety concerns.
medrxiv.org/content/10.110…
I got Pfizer for my first 2 doses, and decided to Modernaize my approach (was given the option w/ thanks).
Some data is emerging showing mixing booster may boost antibody response w/ similar side effect profile & no safety concerns.
medrxiv.org/content/10.110…
11/ More on Waning/Boosters
Read this eloquent piece by @jodyvance (written last week)
"Now here’s my well-protected, double dosed self, whining about waning immunity? This is the COVID-19 equivalent of a first world problem."
Food for thought.
theorca.ca/resident-pod/w…
Read this eloquent piece by @jodyvance (written last week)
"Now here’s my well-protected, double dosed self, whining about waning immunity? This is the COVID-19 equivalent of a first world problem."
Food for thought.
theorca.ca/resident-pod/w…
12/ Global Perspective - Israel
Reminder at the end of summer, well into their double-vax program,
"have been doubling every week to 10 days since then, with the Delta variant responsible for most of them"
They implemented boosters.
science.org/content/articl…
Reminder at the end of summer, well into their double-vax program,
"have been doubling every week to 10 days since then, with the Delta variant responsible for most of them"
They implemented boosters.
science.org/content/articl…
13/ Israel Now
"As the booster campaign ramped up, new Delta infections, hospitalisations and deaths began to dramatically tumble. More than a third of the Israeli population has now been triple-vaccinated."
95-99% cases in hospital are unvaxxed.
abc.net.au/news/2021-10-3…
"As the booster campaign ramped up, new Delta infections, hospitalisations and deaths began to dramatically tumble. More than a third of the Israeli population has now been triple-vaccinated."
95-99% cases in hospital are unvaxxed.
abc.net.au/news/2021-10-3…
14/ Boosters
So, should you get boosted?
As always, depends on community & personal risk, time since 2nd vax, work/life situation etc
Whatever you do, humbly remember, we are fortunate to live in a society where we have access to these life-saving vaccines.
#BCPoli
So, should you get boosted?
As always, depends on community & personal risk, time since 2nd vax, work/life situation etc
Whatever you do, humbly remember, we are fortunate to live in a society where we have access to these life-saving vaccines.
#BCPoli
• • •
Missing some Tweet in this thread? You can try to
force a refresh
