Thread by @hummbugpie

Deconditioning theory officially expelled !! Scientists prove what's causing exertion intolerance in #LongCovid- Link it to ME findings and likelihood of developing #MECFS. Have we just solved the pathology of acute to chronic post viral sequel??
jornaldepneumologia.com.br/details/3604/e…

Can we now fully do away with the biospychosocial theory and start investing research into developing effective treatments?? #BPSbeGone #StopTheHarm #EndTheStigma #FundTheResearch #FindTheTreatments

"through invasive CPET, that O2 delivery was normal and associated with reduced peripheral O2 extraction and elevated mixed venous O2 saturation compared to controls, resulting in reduced peak VO2, indicating lower diffusive O2 delivery to the mitochondria.(3)"

"Corroborating with peripheral muscle impairment due to mitochondrial cellular respiration dysfunction, and not to peripheral muscle deconditioning, a recent case report with muscle biopsy performed after 3 weeks of mild COVID-19 infection evidenced a reduced actin:myosin ratio"

"loss of myosin filaments, thus confirming the presence of primary myopathy by COVID-19 as a cause of chronic fatigue.(9) These findings open a new perspective that suggests that myopathy due to viral injury might be responsible for the persistence of fatigue in long-COVID-19"

"Similarly, it is hypothesized that these patients may develop post-viral myalgic encephalomyelitis/chronic fatigue syndrome with possible associated small-fiber neuropathy, as previously described in other viral infections" #GuillainBarre #CIDP #IvIg #plasmapheresis #apheresis

"damage to olfactory sensory neurons, causing reduced cerebrospinal fluid flow, with congestion of the glymphatic system and subsequent toxic accumulation in the central nervous system.(10,11)." 🧠⏳🤕

"The physical deconditioning theory does not explain the presence of persistent symptoms in patients who were affected by mild forms of the disease, many of whom did not even require hospitalization." 🎯🎯

"In light of the potential complexity and the lack of knowledge on the post-COVID-19 syndrome, it is unacceptable to be simplistic when attempting to unravel the post-COVID-19 syndrome exercise intolerance mechanisms."
☝😍🤸‍♀️🌈🏄‍♀️🤾‍♀️🎯👌✨
#PostViralSequel #NeuroimmuneDysfunction