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Dr Elisa Perego Profile picture
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17 Nov, 5 tweets, 3 min read
Let's make a simple calculation, very rough | 1% of people infected with SARS-CoV-2 die | 10% get Long Covid
1.000 deaths a day in the US could mean 10.000 people getting #LongCovid
This is horrendous | We shouldn't be accepting this level of death | disability | It's inhumane
This is a rough calculation. The mortality rate of SARS-CoV-2 infection can vary in view of age, state of healthcare system etc. | prevalence of #LongCovid is also variable in view of clinical definition, access to care in acute phase, age etc. | But: it's probably MORE than 10%
This overall, ongoing level of death and suffering for a disease we can prevent with a mix of safety measures, from airborne prevention to vaccination, is frankly unacceptable. It's an horrific failure of policy making, public health, leadership and the media.
#LongCovid
This is a new calculation that indicates a prevalence of #LongCovid at 43% after 28 days from symptom onset. It's important to remember that many people who are symptomatic at this point develop longer term symptoms

We don't fully know and understand the longest term sequelae of infection, such as "silent", subclinical damage which will strike in the years and decades to come. This is a phenomenon well documented with other viral infections, even much less severe than SARS-CoV-2
#LongCovid

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More from @elisaperego78

Dr Elisa Perego Profile picture
18 Nov
Another study proves the important long-term cardiovascular damage of SARS-CoV-2 infection 🧵
| sample n=70 PCR + mild to severe covid patients | ~4 month after infection | evidence of endothelial, cardiac ❤ vascular dysfunction❗

#LongCovid #apresJ20

onlinelibrary.wiley.com/doi/full/10.10…
Main finds in the covid sample include: persistent symptoms like fatigue, dyspnea, cough, chest pain | evidence of arterial stiffness | abnormalities in biomarkers of endothelial function | evidence of oxidative stress | evidence of impaired cardiac function
#LongCovid
Two control groups were used n=70 patients each | 1= healthy controls, 2= hypertensive people ⏩ #LongCovid patients show some similarities with the hypertensive controls but with *worse* results in some biomarkers! | impaired cardiovascular function was noted vs healthy controls
Read 7 tweets
Dr Elisa Perego Profile picture
18 Nov
#LongCovid is the grassroots movement who changed how covid is understood and drew new attention to the huge clinical burden of viral-onset diseases and their complex pathophysiology
Patients're expert on their condition. They should be treated as such
Grateful for this community
Those with #LongCovid and allies in the (post) infection disease community #MEcfs have produced top notch advocacy, patient led research and science communication. We have contributed, and are contributing, to change the medical landscape around covid and other chronic diseases
It is of key importance that policy makers, some in the medical establishment, and in public health, fully understand the huge disease burden of SARS-CoV-2 infection and other viral-onset diseases
It is especially imperative in the case of a disease as severe as covid
#LongCovid
Read 6 tweets
Dr Elisa Perego Profile picture
17 Nov
I agree with @apresj20 and the large cohort of top experts who raised severe reservations about the use of serology tests to detect previous SARS-CoV-2 infection | #LongCovid
We know, scientifically, that such tests can't capture SARS-CoV-2 infection with precision in many cases
There is a vast amount of published, peer-reviewed, scientific evidence that addresses SARS-CoV-2 antibody dynamics in both acute and #LongCovid. We know, scientifically, that timing, quality and type of serology assays matter a lot.

#apresJ20 #covidpersistente
We know, scientifically, that not everyone mounts an antibody response to SARS-CoV-2, which is durable and detectable with the tests currently available
Some patients appear do not mount a detectable antibody response at all ---at least against the virus spike protein
#LongCovid
Read 4 tweets
Dr Elisa Perego Profile picture
16 Nov
The #LongCovid community has been calling out and addressing the cardiovascular, endothelial and coagulation sequelae seen in prolonged covid illness since early 2020
We've pointed to prolonged hypoxemia, abnormal coagulation markers, abnormal vascular presentations 🧵
We have alerted researchers, and major health bodies, tried to obtain appropriate medication, raised awareness via social media, conducted patient-led research and advocacy projects, shared info via private channels, talked to journalists about these key features of #LongCovid
We've been comparing our personal medical records and findings with the published literature on acute covid, sequelae of other infections, and then #LongCovid itself
There is now key, peer-reviewed biomedical evidence of coagulopathy, cardiovascular and endothelial sequelae
Read 4 tweets
Dr Elisa Perego Profile picture
13 Nov
#LongCovid is severe, multi-system, potentially disabling and even fatal

It's proven, scientifically, beyond any doubt, that SARS-CoV-2 infection leads to prolonged covid symptoms and sequelae

SARS-CoV, the virus of SARS, caused vast health damage, too

#apresJ20 #covidlong
I and many others like @apresj20 have been fighting misinformation on #LongCovid severity, promoted even by verified accounts on this very same platform

I'll continue to support top-notch biomedical research and advocacy work to ensure care and recognition to patients worldwide
It is a pity to see some scientists, journalists and medical professionals contributing to minimizing the true extent and nature of SARS-CoV-2 infection
This is a great disservice to covid | #LongCovid patients and society in general
We are paying for this misinformation dearly
Read 7 tweets
Dr Elisa Perego Profile picture
12 Nov
It's now proven by a very significant number of publications: sadly, SARS-CoV-2 infection causes prolonged symptoms and damage in multiple organs and body systems 🧵

My gratitude to @apresj20 for their constant effort to promote top-notch science | advocacy on #LongCovid
Multidimensional analysis of SARS-CoV-2 infection long term effects in multiple organs

Increased risk of death even in non severe or critical patients

#LongCovid

@Nature

nature.com/articles/s4158…
Increased risk and proven evidence of kidney injury and chronic kidney disease in #LongCovid

Covid is hard on the kidneys. The numbers estimated by top experts like Dr Al-Aly are sadly enormous

jasn.asnjournals.org/content/32/11/…
Read 34 tweets

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