This Thanksgiving, give your parents a huge hug. When you graduated from high school, you’d used up 93% of the face time you’ll ever have with your parents. We will extend this time, but, for now, give them a huge hug waitbutwhy.com/2015/12/the-ta…
Tips from Tim Urban @waitbutwhy 1. Living in the same place as the people you love matters. I probably have 10X the time left with the people who live in my city as I do with the people who live somewhere else. 2/5
2. Priorities matter. Your remaining face time with any person depends largely on where that person falls on your list of life priorities. Make sure this list is set by you—not by unconscious inertia. 3/5
3. Quality time matters. If you’re in your last 10% of time with someone you love, keep that fact in the front of your mind when you’re with them. 4/5
If you ingest antioxidants, consider this: Free radicals (ROS) activate immune cells that kill cancer. Explains the anti-tumor effect of METFORMIN, a type 2 diabetes drug that may also slow aging 💪 1/ eurekalert.org/multimedia/807…
MitoTEMPO, an antioxidant scavenger of mitochondrial superoxide, abolished the antitumor effect of METFORMIN in mice. Maybe regular anti-oxidants, such as vitamin C, prevent METFORMIN from inhibiting cancer... 2/
The MitoTEMPO data suggests METFORMIN's anti-cancer effect stems from mitochondrial ROS ->"mitohormesis"⚡️You can also induce mitohormesis via EXERCISE (⬇️O2) or hyperbaric O2 therapy (⬆️O2). Does HBOT slow cancer? Yep! This 2021 paper @SciReportsnature.com/articles/s4159…🌪️ 3/
Matcha, or Japanese ceremonial green tea, is one of the world’s healthiest drinks. Not because of antioxidants but survival molecules that Camillia sinensis makes when grown in the shade. When we ingest them, they boost our survival enzymes to fight aging & disease 💪 1/7
We’ve named these special plant defense molecules “Xenohormetins” 🌱 Xeno for between species, hormesis for what doesn’t kill you makes you stronger 🏃♀️ cell.com/cell/fulltext/… 2/7
When we ingest xenohormetins, they turn up survival defense enzymes such as Sirt1 and AMPK, known targets of resveratrol and metformin derived from grape vines and French lilac, respectively 🍷 3/7
In 1963, when 👩🔬👨🔬 thought free-radical damage to DNA caused aging, Smith et al. were studying wasp aging 🐝 Their unexpected results made them ask “if DNA mutation does not explain aging, what other mechanism could be involved?” Cue da epigenome… journals.uchicago.edu/doi/abs/10.108…
One-third of Americans don’t know they are suffering from sky-high uric acid levels, putting them at risk for many age-related diseases. New study 🐀 shows resveratrol pulls uric acid out of the bloodstream & reduces risk tinyurl.com/pux4w386
David Perlmutter will release a his book in Feb called Drop Acid. Was lucky to see an advanced copy…@DavidPerlmutter
You can lower uric acid levels by consuming tart cherries, vitamin C, quercetin, and drinking coffee, like I do
Resveratrol prevents calcification of arteries in rats & lowers zombie (senescent) cell markers via the longevity enzyme SIRT1👇Big effect #Wellbeing 1/4…
2/ Postmenopausal women are at risk of heart disease. These rats were made ‘post-menopausal’ by removing their ovaries. Reference: tinyurl.com/9cxjr4x9
3/ Sections through the aorta. Thinner is more useful. N = control, normal rat; O = removed the ovaries to simulate menopause; E = estradiol replacement therapy; R = resveratrol
Aging news: Abundance of a chemical called a DNA-methyl represents biological age🧬Using this clock, a 2-year study reports that switching to a low-sugar, Mediterranean-style diet with exclusive use of olive oil, slows aging 💪Details in thread tinyurl.com/4atd54s5
2/ The intervention diet included: (a) replacement of refined grains with whole grains; (b) at least one portion of raw vegetables & one of cooked vegetables each meal; (c) fish at least 2–3 times weekly...
3/ (d) reduction of fresh and processed red meat to less than once weekly; (e) consumption of >3–4 portions of legumes / pulses per week; (f) daily consumption of >2–3 portions fruit; (g) cakes & desserts consumed no more than once a week...