1/ I want to take a moment to have a back-and-forth exchange with @MichaelMindrum in a thread, and I’m just gonna keep it to us (Tweet setting) I’m confident we can keep it productive. 👍
First, I think we should get on the same page with where I’m coming from..
First, I think we should get on the same page with where I’m coming from..
https://twitter.com/MichaelMindrum/status/1462477651726282753
2/ I’m not just interested in high LDL for LMHRs. I’m interested in whether it’s meaningful to distinguish high LDL from what appears to be lipid metabolic dysregulation versus high LDL in the context of metabolic fat adaptation.
3/ Much of those following this account know this already from following my work, but often critics do not.
That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
That’s why I’d love to specificity talk to a critic I like, such as yourself, and really unpack this so we can better narrow down where the real disagreements are.
4/ Which brings me back to the two different contexts.
By this point, I hope you‘s agree I rarely discuss LDL risk in isolation – I’m specifically interested in lipid profiles — combination lipid data, like the triad (⬆️LDL+⬆️HDL+⬇️TG)
By this point, I hope you‘s agree I rarely discuss LDL risk in isolation – I’m specifically interested in lipid profiles — combination lipid data, like the triad (⬆️LDL+⬆️HDL+⬇️TG)
5/ Or to put it another way, I would consider the following atherogenic dyslipidemic profile as very concerning: ⬆️LDL+⬇️HDL+⬆️TG
… even if high LDL is the common denominator between both profiles.
… even if high LDL is the common denominator between both profiles.
6/ (⬆️LDL+⬆️HDL+⬇️TG) is understudied, but the limited data we do have shows it has a great deal of relevance toward cardiovascular outcome.
That’s where my focus is – not on LDL alone – much less on data around LDL without context into metabolic health or genetic abnormalities
That’s where my focus is – not on LDL alone – much less on data around LDL without context into metabolic health or genetic abnormalities
7/ and that has to be the starting point for any in-depth discussion on what I personally hypothesize regarding ApoB/LDL and its role in this larger puzzle of energy distribution and risk. CholesterolCode.com/model
8/ So before going further – I really do want to be sure that you understand this important point. That I believe lipid profiles are more often a reflection of health or disease than they are drivers of it. But I also acknowledge this is a hypothesis being tested/researched…
9/ Can I confirm you follow me fully up to this point?
It’s important– because I want to avoid further reductionism toward simply LDL in isolation past this.
(if you think most who follow this account believe it’s all about LDL and not about the above, I’m happy to poll again)
It’s important– because I want to avoid further reductionism toward simply LDL in isolation past this.
(if you think most who follow this account believe it’s all about LDL and not about the above, I’m happy to poll again)
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