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26 Nov, 5 tweets, 3 min read
✨CoVariants.org Now Updated✨
B.1.1.529 is designed @nextstrain clade 21K & is now included on covariants.org/variants/21K

Note that data is still incoming! I currently only have the first sequences detected & will update as soon as I have additional sequences.

1/4
The 21K (B.1.1.529) page offers some information about some of the observed mutations - but I'd welcome contributions to link to more research!

On the right you can see the defining mutations - note that nonsynonymous mutations aren't yet available - I'll add them soon.

2/4
You can also see 21K (B.1.1.529) on the Shared Mutations page (& too big to screenshot!) to compare what Spike mutations we also see in other variants.

covariants.org/shared-mutatio…

3/4
A 21K (B.1.1.529) focal build is in the oven 🥖 - the link on the 21K page will work as soon as it's done (probably on Twitter too).

Protein structure also still to come!

Again: data is still incoming & preliminary! Will update as much as possible.

4/4
Apologies that I cannot seem to write "designated" correctly today!
B.1.1.529 has been *designated* as 21K - not designed.

5/4

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Dr Emma Hodcroft Profile picture
25 Nov
Lots of headlines about B.1.1.529 today.

Thoughts: Yes, this variant has a high # of spike mutations, & a few known to cause changes. But, we've seen previous variants that looked worrying & never took off. We should watch & wait for more data to estimate how concerning this is.
As a catch-up for those who haven't seen said headlines, I think this @guardian article on it gives a fair summary, with some level-headed quotes from scientists.
theguardian.com/world/2021/nov…
We got some additional information this afternoon from a press conference with @Tuliodna & @rjlessells. You can watch it below. A brief touch on some of the new information.

Read 12 tweets
Dr Emma Hodcroft Profile picture
9 Nov
"What's the situation in Europe?"
Yes - cases are rising in many places 📈
But it's difficult to talk about 'Europe' 🌍 as one entity right now: as the pandemic continues, things are getting more heterogeneous. 📊

*What one country can manage, may not be true for another*

1/16
First, we have to look both at absolute case numbers & change in case numbers - some places with high cases may see a decrease but remain high 📉, others with lower numbers might be seeing a concerning sharp increase 📈

2/16

ourworldindata.org/covid-cases
Some, like the UK, seem to be dipping up & down around fairly high numbers, making 2-week changes harder to interpret - will there be another bump..?

Others, like Norway, have recent spike, but are at relatively lower cases. Will current spike be contained as before..?

3/16
Read 16 tweets
Dr Emma Hodcroft Profile picture
12 Aug
"Thing is, we have a chance to build office work from the ground up: to re-evaluate the old 9-to-5, to relocate city centre offices, to let people work tight 4-day weeks, to realise that working smart is better than the old-fashioned idea of working hard"

theguardian.com/commentisfree/…
From chatting to people, I think the main reason those high up want people to come back to the office is simple: control.
Even when productivity metrics indicate all is well, bosses don't trust employees & like to be able to physically check on them. Not related to actual output.
I'd be super curious in any survey difference between how much superiors miss "stopping by to chat" vs how much their employees feel similarly.
Read 4 tweets
Dr Emma Hodcroft Profile picture
11 Aug
Headlines like the one circulating about India always need to be taken cautiously: until we have sequence data, speculation about a new variant or new mutations is entirely that - speculation.

But let's dig into what's being reported right now about 40,000 breakthroughs...

1/N
Headlines are saying things like "40,000 breakthrough COVID cases". But what does breakthrough mean here? Most generally, at least in Western media, this is used to refer to infections in fully-vaccinated (commonly 2-dose) people.

2/N
However, 1 site reporting the 40,000 defines this as "people contracting the disease a second time or fully vaccinated".
Another implies this is infection after 1 or 2 doses.

3/N
indiatoday.in/coronavirus-ou…

news18.com/news/india/ker…
Read 7 tweets
Dr Emma Hodcroft Profile picture
28 Jul
Today, my best birthday present is being fully vaccinated! 🎂

But so many still aren't - & the pandemic has wrecked havoc on routine vaccinations too.

Donate to @gavi, @UNICEF or others & I'll match up to $500! Send your receipt to vaccine_donations@protonmail.com & plz RT!

1/
As well as desperately requiring stronger action towards more equitable #COVID19 vaccination, the pandemic has meant so many children weren't able to get basic vaccines.

This could add unnecessarily to the already too-large burden of the pandemic.

2/
who.int/news/item/15-0…
The pandemic has hit a lot of people hard in many ways, including financially. Please do not give if it would cause you hardship. ❤️

There are other ways you can help!
Talk to an unvaccinated friend 🗣️, or put pressure on your government to do more to help globally! 📨

3/
Read 4 tweets
Dr Emma Hodcroft Profile picture
19 Jul
I want to repeat what others have said:

**If you do not get vaccinated against SARS-CoV-2, you /will/ get infected one day.**

We won't eliminate SARS-CoV-2.
The choice isn't "vaccine or not" - it's "vaccine or infection". This is critical for weighing up risks/unknowns.

1/5
If the mindset is "vaccine or not", it is easy to think that waiting & watching is safer, because you stay in 'nothing happens' territory.

But this isn't accurate. As we see now: unvaccinated people are where cases are spiking & this is going to remain true for a long time.

2/5
I still hear concern from people about the 'unknown long-term effects' of vaccination.

But what I don't hear people also considering is the unknown long-term effects of COVID-19.

Or a fair comparison of the well-known shorter-term effects & risks of both.

3/5
Read 5 tweets

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