2/8 The notion that in some cases food can be a medicine rings true. For better or for worse, diet can change one’s physiology.
One of the more popular diets today is the high-fat, very low-carbohydrate diet, also known as a ketogenic diet.
3/8 In some, the ketogenic diet may help to ameliorate obesity and type 2 diabetes and positively affect problematic cardiometabolic markers. pubmed.ncbi.nlm.nih.gov/25287761/
4/8 However, a recent paper published in the Journal of Clinical Lipidology highlights five cases in which patients had severe lipid perturbations while on the diet.
5/8 The subjects were found to have elevated total cholesterol and low-density lipoprotein cholesterol (LDL-C). These lipid perturbations were due to pre-existing conditions driven, in part, by genetics.
6/8 The diet did not cause aberrant baseline lipids in these instances. Rather, the diet may interact with intrinsic factors to exacerbate underlying conditions.
7/8 The bottom line? Those who start a ketogenic diet or have experienced abnormal physiological responses to this diet can and should be tested for underlying predispositions.
8/8 Irrespective of the diet someone chooses, one thing is for certain: people vary greatly in their response to any given diet, so it’s important to track and assess each scenario on an individual basis.
1/9 Cardiovascular disease is one of the most prevalent diseases in the developed world.
One of the scariest things about #heartdisease is that it is often a silent killer, with few to no outward symptoms.
2/9 As one of my medical school professors liked to point out, the most common "presentation" of the disease is a sudden, fatal heart attack. You know the patient has heart disease because he has just died from it.
3/9 And while mortality rates from those first, surprise heart attacks have dropped significantly thanks to improvements in basic cardiac life support and time-sensitive interventions, such attacks are still fatal roughly 1/3 of the time.
1/11
Does Exercise Affect Lifespan?
This week’s newsletter highlights how knowing the answer in advance can undermine science. bit.ly/3HZhS8u
2/ Regular physical activity is one of the most important things people can do to improve their health. Exercise is associated with the reduction in risk of many adverse conditions, including: metabolic dysregulation, cardiovascular disease, cancer, neurodegeneration, and more.
3/
But is exercise a marker or a maker of improved health? Are all types of exercise created equal when it comes to longevity? Until recently, these questions had not been addressed in a randomized controlled trial (RCT). Enter the Generation 100 study. bmj.com/content/371/bm…
In the following thread I touch on the recent discussion on Covid19 hypoxia/hemoglobinopathy theory, its implications, problems with the proposal, how to test it, and alternative explanatory theories. (1/9)
A recent computational biology preprint publication proposed that non-structural proteins coded for by COVID-19 could bind to hemoglobin and “knock-out” iron atoms, disrupting the ability of red blood cells to carry oxygen. (2/9)
If correct, infected patients would not be able to deliver adequate oxygen to their organs even if able to breathe freely. In this paradigm, hypoxia precedes ARDS instead of the other way around. (3/9)
(1/8) Up before the enemy! @jockowillink is rubbing off on me... I’m normally up at 5:00 or 5:30, but don’t work out until 7 or so. Today I’m getting up at 3:30 and working out at 4:00 as part of my long-haul jetlag plan.
(2/8) I’m flying east today 9 hours (PST to EST; layover, then EST to GMT+2 = total of 9 hours). This kind of trip used to cripple me when I didn’t know how to manage jet lag. Now I can do it effortlessly.
(3/8) OBJECTIVE: adjust to new time zone as quickly as possible (i.e., day of travel)
STRATEGY: the moment I wake up, assume I’m in destination time zone and manage my adenosine, cortisol, and melatonin accordingly
(1/8) I often get lots of questions about wearables. Most of the questions are about a specific device and whether I use it or think it has any value. That obviously depends on what you want to get out of the information the wearable provides you with.
(2/8) In general, I find the vast majority of wearables of little use to me. Why is this the case? Because they don’t fit my framework for what I think a wearable needs to address. My framework for what must be true of a “good” wearable (Attia Postulates):
(3/8) 1. What you’re measuring matters (e.g., HRV—matters vs. # steps taken—not so much). 2. What you’re measuring differs from day to day in ways that are not intuitive or linear (see above).