The first author of this paper is the patient.

Raw deal. Vax may have accelerated oncogenesis? And he still has cordial things to say about the vaccines risk/reward.

It’s a preprint

frontiersin.org/files/Articles…
We touch on some of hypothetical pathways for this in this paper with the now Joe Rogan Pal Peter McCullough.

osf.io/bcsa6/
Link to the paper that has that image here.

frontiersin.org/articles/10.33…
Correction-
Says Corresponding Author and they are both Goldman’s.
Mixed that up.
The comment on the risk/reward equation from the author should be weighed in light of previous publications from this author.
Irony would have it that the title is about “Fake News”

And the article has an Erratum posted.

I don’t claim to be error free in my publications but given this paper seems to advocating for search engine scrubbing of vaccine misinformation….
Maybe the authors could reflect on how that is in direct conflict with their transparency virtue signaling mentioned in their summary.

Decentralize Search.
@BrendanEich

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More from @Kevin_McKernan

16 Dec
Here we can see honest virologists being confronted by ones that might have been named in Fauci’s email.

The later amplify flawed preprints from Drosten.

The reads are not out yet (of course), so there is not much to say about this headline whore print.
Let’s have a look at the methods section of the paper.

2 rounds of 45 cycles of PCR?

This is what you do if you want to make polymerase slippage errors near GC rich triplet repeats.

People this library illiterate shouldn’t have the keys to $20K NovaSeq runs. Image
Having engineered very accurate sequencers, to address PCR polymerase error, you must utilize DNA barcodes that get attached to your PCR products in the first cycle of PCR. Any barcode that over amplifies through the PCR process is discounted.

For rare variants
This is the way Image
Read 4 tweets
11 Dec
Of the many mutations in omicron the most interesting two are in the SEB domain.

Staphylococcus Enterotoxin B is a peptide that is classified as a bioweapon.

When ingested it creates symptoms very similar to COVID and it’s know to trigger cytokine storms Image
It’s well described in Cheng et al.

This known toxin was warp sped into spike only Vaccines.
SEB is directly adjacent to the FCS.

Let’s have a look at what Ahanotu et al has to say about SEB exposure and it’s capacity as a bioweapon.

pnas.org/content/117/41… Image
Exposure to these peptides has been known to cause cytokine storms.
They are superantigens.

liebertpub.com/doi/pdfplus/10… Image
Read 14 tweets
7 Dec
Spike Escape and directed evolution.

For those who missed it.

anandamide.substack.com/p/directed-evo…
For those in need of more evidence…

pubmed.ncbi.nlm.nih.gov/34873910/
Ooops.
Read 7 tweets
5 Dec
Lots of talk about viral recombination this week in light of Omicron.

You know what promotes such things? Image
Quadruplex G formations and degenerate bases.

journals.plos.org/plosone/articl… Image
While I suspect omicron is a directed evolution lab experiment that leaked….

We now have the added complexity of there being patients that have both C19 and the pseudouridine based mRNAs.
Do these recombine/strand switch?
Lots of degenerate bases = more noise in spike.
Read 4 tweets
25 Nov
When you Warp Speed your codon optimizations and forget to look to at quadruplex G formation.

These mRNA Vaccines should be considered Pro-Drugs, where proof of the final drug is measured, not assumed.
osf.io/bcsa6/
So Molbio folks like to Jack the expression of genes sadly assuming that more is better.

To do this they add strong beta globin promoters and swap the synonymous bases in the codons out with more human like codons.

This is called codon optimization.
There are consequences
First consequence is you tend to shift the GC content of the mRNA significantly when you do this.
36%->61%.

But one should question why your believe the virus ,which is already adapted to its host) needs this tweak?

It doesn’t come risk free.
Read 8 tweets
10 Nov
I wonder what could go wrong codon optimizing a virus that is already adapted to its host?

What made them think maximum expression was desirable?

Top Track- SARs-CoV-2 GC content over spike.

Bottom- BNT162b2 GC content. Image
They certainly weren’t thinking about secondary structure.

This type of stuff matters to RNAses and other components of the innate immune response (Toll Like Receptors).

Yes, their goal was to evade innate detection with pseudouridine but at what cost? Image
These types of modifications create stop codon ablations and many translation errors.

Has anyone see protein sequence data of the spike protein expressed in vaccinated people?

This seems like a major regulatory oversight.
Read 17 tweets

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