I honestly cannot believe that we're living in a country where our govt is acting against scientific advice once again, and delaying action on rapid exponential growth, fully aware of the consequences- for the fourth time- a stance normalised by a complicit media.🧵
With a rapidly growing new variant doubling every 2 days, increasing hospitalisations already in London, which is ahead in terms of spread. The lags between infection and hospitalisation haven't happened yet, so this situation will only get worse.
We're seeing the highest hospitalisation rates with COVID-19 we've ever seen in 0-5 year olds, and rising.
Our govt has been warned repeatedly by their own scientific advisors that the NHS could be badly overwhelmed - even in the best case scenario. They've been warned that early action is needed by SAGE, by SPI-M-O. And they've chosen to ignore this once again.
And what has a lot of MSM done? Rather than challenge them robustly on this, they've chosen to question the modelling and the science. They've chosen to present false dichotomies between healthcare for other conditions, and COVID-19.
They've repeatedly platformed scientists behind the GBD - who have been pushing 'herd immunity' rhetoric for over a year and have been dangerously wrong about everything. Importantly, they haven't communicated the seriousness of the crisis we are in, and what inaction will mean.
Disinformation groups like HART and UsForThem are deeply entrenched within govt, and have access and influence, with ministers quoting 'herd immunity through infection' GBD proponents to justify inaction at this critical time, against their own advisors.
And scientists who have consistently put out misinformation are still continuing to minimise the impact of omicron through 'good news' hopium without evidence - also in effect normalising govt inaction.
I know the massive impact on the NHS isn't necessarily being felt now- but, by the time the impact is felt & we act, we'll be several doublings in, which means substantially higher hospitalisations will already be baked in - because so many more people will have been infected.
And we started from a place where ambulances in England were on black alert, and waiting times for A&E and ambulances were dangerously high. What happens when this already overwhelmed system comes under more pressure?
And it's not slightly more pressure. In the best case scenario SAGE models show 2-3x the number of daily COVID-19 hospitalisations we have now. Our system simply can't cope with this. It may mean people not able to access life-saving emergency care. We're already partly there.
When health systems break down, there's no explosive marker for this. Staff and systems stretch and stretch, and what happens is that people who need care just aren't able to get it in time. Or people need to be discharged earlier even if they're not fully recovered to make space
Ultimately, it results in more death, more disability (e.g. stroke/heart attacks where treatment wasn't in a given window) not just at that point in time but often even in the future for chronic illnesses where people weren't able to get timely treatment. And trauma among staff.
Here's a poignant piece by @ShaunLintern that illustrates this:
Waiting in the face of exponential growth is accepting mass suffering, devastation of health systems, and death. This is what our govt is doing, and a lot of MSM is normalising while talking about christmas parties. Have they informed the public about this stark reality?
When the media questions the science rather than a murderous govt policy in the midst of a crisis that will severely impact thousands & cause loss of life - you know our country is in a very dangerous place.
Over the past year we've seen the value of life drop ('acceptable deaths') especially for the disabled & vulnerable. We've seen blatant corruption & attempts to evade accountability, power grabbing by govt to avoid scrutiny, erosion of human rights and independent media.
We know where this path leads. And I feel powerless as do many others to do anything about it. And those who can, just won't.
Not sure why the rest of my thread isn't appearing here in continuation, but have linked it below:

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More from @dgurdasani1

22 Dec
🧵on the Imperial study on omicron severity TL;DR:
-*intrinsic* omicron severity similar/bit lower to delta
-*observed* severity lower due to omicron more likely to re-infect
-vaccine efficacy against hosps maintained
-growth rate likely to override impact of lower severity
Before I get into the rest, I want to re-emphasise that the overall impact of omicron will be determined by growth (exponential) and severity (linear)- even with lower severity, growth in itself will cause serious impact at population level, even if severity is moderately lower.
The Imperial study is a complex piece of analysis, and I have to commend the Imperial team for dealing with important confounders in the analysis.

I want to first explain this a bit more.
Read 32 tweets
22 Dec
A thread slightly borne out of frustration on the widely misrepresented discourse on long COVID, esp in children. This is for the 'long COVID studies in children with controls are rigorous and loads of controls have symptoms so not sure this syndrome is real or important' group🧵
First, controls per se *do not* make a study sound - How do you account for the fact that children are often asymptomatic acutely, serorevert quickly or don't seroconvert at all. Long COVID itself is associated with lower Ab levels, furthering this bias.
Rigorous science is v. important, but let's not pretend that studies are rigorous because they have controls (just like people pretend RCTs are superior to observational evidence by virtue of being RCTs, even if they're conducted badly).
pubmed.ncbi.nlm.nih.gov/34273064/
Read 31 tweets
21 Dec
An important study- it suggests that Omicron has a much greater growth advantage among the vaccinated, and previously infected, and possibly a lower growth advantage compared to delta among those who were susceptible (not vaccinated/infected or waning of immunity)
This doesn't mean vaccines are not effective. It means that among the vaccinated and previously infected, omicron has a higher advantage compared to delta because it has higher escape from immunity (although both have lower infective probability compared to unvaccinated)
It's possible that intrinsic transmissibility of omicron relative to delta (apart from escape) may not be much higher, or possibly even slightly lower. But it would still have a massive advantage among those with prior immunity through vaccines/infection.
Read 10 tweets
20 Dec
Wrong. SPI-M-O modelling has a lot of uncertainty because of many unknowns which are clearly acknowledged. Saying we didn't have 200K deaths last yr (um... because govt responded with lockdowns!) is disingenous & misleading.🧵
SAGE modelling has predicted outcomes within their range of uncertainty more often than not. And they're very clear about the uncertainties. If you don't know this perhaps try listening to experts who have followed it closely.
Even where the predictions haven't been exactly in the range, the general direction of movement, and policies advocated for have been sound. E.g. not removing mask mandates over summer would've saved lives and prevented a lot of long COVID even if cases didn't reach massive highs
Read 7 tweets
20 Dec
On @TimesRadio with @MattChorley just now - who for some reason invited me on as an expert, didn't like it when I challenged his flawed narratives on SAGE modelling, and then never gave me a chance to respond - and hung up on me when challenged!
This is MSM- and they are very much responsible - as I said in my interview for putting out false narratives. I mean saying that modelling is flawed because we didn't have 200K predicted deaths in yr 1 of the pandemic is just lazy. We acted- we locked down in response to crises.
What do you think would've happened had we not? There has been a lot of uncertainty in SAGE modelling, which the modellers acknowledge clearly- and media often picks on one scenario to critique them. Not even acknowledging that action was taken in response.
Read 8 tweets
19 Dec
If you want to know what it's like being a Brown female scientist, this tweet captures what I deal with every day. Despite having called most things right & advocated for early response to protect public health and lives, time & time again, I'm attacked & abused. 🧵
Very few people know, let alone understand, what it's like being an outspoken woman of colour in academia. If you want to know I'd recommend talking to some. It hurts. Every day.
I've been outspoken and challenged injustice all through my career, from medical school to now. I've suffered *hugely* as a result.
Those who've known me for a while will know that I was dismissed from the @sangerinstitute after whistleblowing.
Read 26 tweets

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