“In the United States, mortality trends typically trail case trends by about three weeks- which means the Omicron surge, which began more than a month ago, should be visible in the death counts. It isn’t yet.”

Let’s talk about that. 🧵
NOTE: Source for ALL the information above AND in this thread can be found here. I highly recommend David Leonhardt’s “The Morning” Newsletter.
nytimes.com/2022/01/05/bri…
“The details of the Omicron variant are becoming clearer, and they are encouraging. They’re not entirely encouraging, and I will get into some detail about one of the biggest problems- the stress on hospitals, which are facing huge numbers of moderately ill COVID-19 patients.”
“So I want to be clear: The latest evidence about COVID is largely positive. A few weeks ago, many experts and journalists were warning that the initial evidence from South Africa- suggesting that Omicron was milder than other variants-might turn out to be a mirage.
It has turned out to be real.” nytimes.com/2021/11/29/bri…. In hospitals around the country, doctors are taking notice. “This wave of COVID seems different from the last one.” nytimes.com/2022/01/04/hea….
“There are at least three main ways that Omicron looks substantially milder than other versions of the virus:

1. Less Hospitalization: Somebody infected with Omicron is less likely to need hospital treatment than somebody infected with an earlier version of COVID.
“An analysis of patients in Houston found that Omicron patients were only about one-third as likely to need hospitalization as Delta patients. In Britain, people with Omicron were about half as likely to require hospital care, the government reported.”
Hospitalizations are nonetheless rising in the U.S., because Omicron is so contagious that it has led to an explosion of cases. Many hospitals are running short of beds and staff, partly because of COVID-related absences. In MD, more people are hospitalized with COVID than ever.”
"We have 92% of our state vaccinated- but we have overflowing hospitals. So, that 8% of the population who has not been vaccinated is responsible for 75% of all the people that are filling up our COVID beds in the hospital." -Maryland Governor Larry Hogan cnn.com/videos/politic…
“Thankfully the COVID patients aren’t as sick. But there’s so many of them,” Craig Spencer, an emergency room doctor in New York, tweeted on Monday, after a long shift. “The next few weeks will be really, really tough for us.”
2. Milder hospitalization: “Omicron is not just less likely to send somebody to the hospital. Even among people who need hospital care, symptoms are milder on average than among people who were hospitalized in previous waves.”
A crucial reason appears to be that Omicron does not attack the lungs as earlier versions of Covid did. Omicron instead tends to be focused in the nose and throat, causing fewer patients to have breathing problems or need a ventilator.” nytimes.com/2021/12/31/hea…
“In London, the number of patients on ventilators has remained roughly constant in recent weeks, even as the number of cases has soared, John Burn-Murdoch of The Financial Times noted.” ft.com/content/d07f45…
3. Deaths: The increase in deaths is unlikely to be anywhere near as large as the increase last summer, during the Delta wave. Look at the data from South Africa, where the Omicron wave is already receding. Bottom line? Make sure you’re protected. Don’t walk around immune naive.

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More from @sailorrooscout

3 Jan
Guys, B.1.640.2 isn’t new. It actually PREDATES Omicron. It's a sub-lineage of B.1.640- which caused some concern back in mid-November but couldn’t even compete with Delta. B.1.640.2 was first sequenced OVER a month ago and was officially recognized as a lineage in December.
As Tom points out, there haven’t been any new sequences uploaded since before Christmas and this variant has had a decent chance to cause issues but never really materialized. It’s been classified as a Variant Under Monitoring by WHO since November. Let’s focus on Omicron.
If you need background on this I went over it all here. Approximately THREE days ago.
Read 14 tweets
3 Jan
A CWRU School of Medicine study of 577,938 pediatric and adult patients shows first time SARS-CoV-2 infections occurring at a time when Omicron was rapidly spreading were associated with significantly less severe outcomes than first time infections when Delta predominated. 🧵
It is IMPORTANT to note severity of disease in humans is NOT determined only by virus replication but also by the host immune response to the infection. Make sure you are PROTECTED. Source for the information above can be found here: medrxiv.org/content/10.110… PLEASE NOTE. Image
Currently, data on the severity of the disease caused by the Omicron variant compared with the Delta variant has been limited. Here, researchers compared 3-day risks of emergency department (ED) visit, hospitalization, intensive care unit (ICU) admission, & mechanical ventilation
Read 15 tweets
2 Jan
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.
The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout late last year, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.
Read 12 tweets
31 Dec 21
@_almond_tree May I make a suggestion. This isn’t new. The preprint just got uploaded like two days ago but that’s it. If anyone does a Google search they’ll see this pops up as early as October/November deseret.com/coronavirus/20… and hasn’t done much. Omicron kinda blew this out of the water.
@_almond_tree This has been under monitoring with B.1.640 being first detected in September 2021. ecdc.europa.eu/en/covid-19/va…. I know everyone is looking for the “next big thing” but context is important. The preprint just got uploaded on 12/29 which is why some people think it’s “new.”
@_almond_tree I mean, it didn’t even get to spread far due to Delta. Now with Omicron, if this variant couldn’t stand to Delta it likely wouldn’t be able to against Omicron either. Again, it’s been under monitoring, that’s it. Image
Read 5 tweets
31 Dec 21
Encouraging news out of South Africa. Study data has suggested South Africa’s Omicron peak has indeed passed with NO major spike in deaths OR hospitalizations.
The study looked at the rate at which the fourth surge in cases progressed in the South African city of Tshwane, which researchers described as the "global epicentre" of the Omicron wave.
Researchers looked at hospital records from a Tshwane hospital system and compared them to prior surges. Based on their analysis, the omicron wave "spread and declined in the City of Tshwane with unprecedented speed peaking within 4 weeks of its commencement."
Read 7 tweets
30 Dec 21
Them: Is there any other vaccine in history that required three doses in a year and yet still didn’t prevent transmission of the virus it was meant to protect against?

Me: Your childhood vaccinations would like a word with you.
Before I forget, reminder that your TDap: Tetanus-Diphtheria-Pertussis (every 10 years) are technically a repetitive vaccine series or rather boosters during adulthood. HPV is another vaccine that could fit here as well.
“Even the measles vaccine, which is incredibly effective, fails to protect about 3% of vaccinated individuals who are exposed to the virus. Jonas Salk's polio vaccine-hailed a medical miracle- was 80% to 90% effective at preventing paralysis caused by the polio virus.”
Read 4 tweets

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