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🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
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6 Jan, 5 tweets, 3 min read
Pointless bureaucratic torture “endless meetings where you know nothing would get done” forces @SpaceXStarlink India chief to quit, in huge setback to the image of India as a business friendly destination. @SpaceX @NITIAayog #StarLink
republicworld.com/india-news/gen…
Image
If there is to be any movement on Starlink from Indian bureaucracy, @SpaceX has to take 5% stake in Mukesh Ambani or Adani companies in true Mark Zuckerberg style.
Starlink is a threat to Reliance investment in Telecom.
Unless your name is Adani or Ambani, you are not welcome for business

m.economictimes.com/news/company/c…
m.economictimes.com/news/company/c…

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More from @abledoc

🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
8 Jan
Early use of high titer neutralisatiing Convalescent Plasma in outpatients reduce hospitalisation. 1/n
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110… Image
So what was wrong with previous attempts at Plasma therapy?
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
Why do we need convalescent Plasma in the age of Monoclonal antibodies?
Most monoclonal antibodies are ineffective against Omicron and the ones that retain activity are limited in supply and hoarded by @JoeBiden
Other folks at high risk may need an alternative 3/n
Read 5 tweets
🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
28 Jul 21
Shielding Strategy where high risk individuals in UK were told to "shield" themselves from #COVID19 a huge failure in Scotland as the shielded subjects contracted severe covid at higher rates. @dgurdasani1 @PaulNuki @pash22 #shielding #SARSCovid2
bmcmedicine.biomedcentral.com/articles/10.11…
High Risk Individuals eligible for shielding had higher exposure to hospitals.
bmcmedicine.biomedcentral.com/articles/10.11…
Recent exposure to hospitals were associated with increased risk of Covid19 in high risk individuals eligible for shielding in Scotland.
bmcmedicine.biomedcentral.com/articles/10.11…
Read 8 tweets
🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
27 Jul 21
What has been the true extant of the COVID19 pandemic in United states after accounting for underdiagnosis and misreporting? The pandemic still has a long way to run its course. #COVID19
pnas.org/content/118/31…
Has United States reached sufficient levels of Immunity to prevent another wave. While 80% of the popultion may have some immunity, this is subject to R0
R0 started at 6, and the virus has become 2.5 times more infective. Probably higher levels needed.
pnas.org/content/118/31…
Course of the epidmic in terms of Incidence, reproductive rate R(t) and cumulative cases in Ohio and Indiana
Natural infections have only reached 20-25% and the gap needs to be filled by vaccination.
Read 4 tweets
🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
6 May 21
"Social Distancing" is a term coined by (math inclined) epidemic modellers and misunderstood by public & even by most public health "experts"
So what does it mean. 1/n
Lets start with the factors affecting R0 (Basic Reproductive Rate) that critically determines an outbreak...
R0 (Basic Reproductive Rate)
= (Avge number of people one meets in a day) * (Probability of Transmission) * (Number of Infective days)
Thus R0 is not a fixed number but influenced & modified by behaviour.
Meeting & interacting with fewer people reduces R0 (Social Distancing) 2/n
Keeping 2m/6 feet distance distance reduces droplet transmission (Probability of Transmission, 2nd term), physical distancing is confused as Social distancing
Masks, Vaccination etc all reduce the second factor in R0
@s_harley1 @PriyankaPulla @JoyAnnReid
3/n
Read 9 tweets
🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
24 Jan 21
Bats are diverse. There exists 1423 known species, with considerable sequence variation in viral receptors (eg DPP4 and ACE2) increasing the likelihood that mere exists a coronavirus variant that spilling into humans.
DPP4 is the receptor for MERS while ACE2 is the receptor for SARS. The variation in these receptors among bats greater than that between humans and other species of mammals. We still don't know the identity of bat species from which COVID19 came.
Bats have exceptionally long lifespans for their size. Bat Immune system has adaptations that allow them to harbour viruses without getting ill. They have constitutive activation of interferon pathway while other pathogenic pathways are reduced.
Read 5 tweets
🟣 Dr Able Lawrence MD DM🦉周天堂 Profile picture
22 Jan 21
Here is a thread on what people with heart disease should consider before taking vaccine 1/n
People with heart disease are at increased risk from COVID19 not only due to heart disease but also from diabetes & hypertension. Thus benefits of vaccination are greater. Now the nuance
Reports of sudden deaths following vaccination have received widespread coverage, mostly in the old (Norway) as well as young (Karnataka, India & Portugal) attributed to Cardiac events. This has to be seen against millions vaccinated. Risk of COVID19 death above 70 is 14% 2/n
One can say a particular mode of death is attributable (partially or fully) to vaccination if it is raised above the baseline risk. Even still benefits of vaccine outweighs risk.
Let's discuss whether vaccine can plausibly trigger cardiac events in high risk individuals 3/n
Read 12 tweets

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