Early use of high titer neutralisatiing Convalescent Plasma in outpatients reduce hospitalisation. 1/n
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110…
#COVID19 #PlasmaTherapy
medrxiv.org/content/10.110…
So what was wrong with previous attempts at Plasma therapy?
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
1) Reliable assays for Neutralising Antibodies werent widely available earlier
2) We did not know what titer was high enough
3) Most studies were done in serious ill hospitalised patients 2/n
Why do we need convalescent Plasma in the age of Monoclonal antibodies?
Most monoclonal antibodies are ineffective against Omicron and the ones that retain activity are limited in supply and hoarded by @JoeBiden
Other folks at high risk may need an alternative 3/n
Most monoclonal antibodies are ineffective against Omicron and the ones that retain activity are limited in supply and hoarded by @JoeBiden
Other folks at high risk may need an alternative 3/n
What other caveats are there?
Since past infections by other strains don't produce neutralisation against Omicron, plasma will have to be variant specific (Omicron to Omicron. Delta can still use Regeneron MAb)
We still have no idea about NAbs in convalescent Omicron Plasma 4/n
Since past infections by other strains don't produce neutralisation against Omicron, plasma will have to be variant specific (Omicron to Omicron. Delta can still use Regeneron MAb)
We still have no idea about NAbs in convalescent Omicron Plasma 4/n
@threadreaderapp unroll
Finally, we need to think whether we need any of this against Omicron, especially early on.
I would rather focus my attention on controlling hypertension, diabetes and other cardiovascular risk 5/5
I would rather focus my attention on controlling hypertension, diabetes and other cardiovascular risk 5/5
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