A new analysis out of the CDC shows just how extremely effective COVID-19 vaccines are against COVID-19 associated hospitalization and death. Among 1,228,664 fully vaccinated individuals across the United States, 185 (0.015%) had severe illness and 36 (0.0033%) died. 🧵
Using data from 465 facilities in a large U.S. health care database, this study assessed the frequency of and risk factors for developing a severe COVID-19 outcome after completing a primary COVID-19 vaccination series, defined as receipt of 2 doses of an mRNA vaccine (BNT162b2
[Pfizer-BioNTech] or mRNA-1273 [Moderna]) or a single dose of JNJ-78436735 [Janssen (Johnson & Johnson)] ≥14 days before illness onset. Severe COVID-19 outcomes were defined as hospitalization with a diagnosis of acute respiratory failure, need for noninvasive ventilation (NIV),
admission to an intensive care unit (ICU) including all persons requiring invasive mechanical ventilation, or death (including discharge to hospice).
Risk factors for severe outcomes included age ≥65 years, immunosuppressed, and six other underlying conditions. All individuals with severe outcomes had AT LEAST one risk factor; 78% of individuals who died had at least four. To help those who are most at risk we have several
mitigation measures we can utilize such as boosters, proper ventilation, and masks. You can find this analysis here: cdc.gov/mmwr/volumes/7…
For those who are asking about Long COVID. The latest Long COVID study shows a 50-80% REDUCTION in 7/10 most commonly reported symptoms 4-11 months following a SARS-CoV-2 infection in vaccinated individuals versus unvaccinated individuals. “Vaccination with at least two doses of
COVID-19 vaccine was associated with a substantial decrease in reporting the most common post-acute COVID-19 symptoms. In addition to reducing the risk of acute illness, COVID-19 vaccination may have a protective effect against long COVID.” medrxiv.org/content/10.110…
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Just a heads up. Regarding “Deltacron” or the “new variant” out of Cyprus. Please be aware those sequences being reported by media outlets right now appear to be due to contamination. It is NOT a new variant.
Per @PeacockFlu “they do not cluster on a phylogenetic tree and have a whole artic primer sequencing amplicon of Omicron in an otherwise Delta backbone.”
When processing several COVID samples at the same time, procedural failures can occur, and contaminations between samples with different variants occur. As @wanderer_jasnah says, it is PCR recombination due to contamination. Usually computational analysis can detect these flaws.
“In the United States, mortality trends typically trail case trends by about three weeks- which means the Omicron surge, which began more than a month ago, should be visible in the death counts. It isn’t yet.”
Let’s talk about that. 🧵
NOTE: Source for ALL the information above AND in this thread can be found here. I highly recommend David Leonhardt’s “The Morning” Newsletter.
•nytimes.com/2022/01/05/bri…
“The details of the Omicron variant are becoming clearer, and they are encouraging. They’re not entirely encouraging, and I will get into some detail about one of the biggest problems- the stress on hospitals, which are facing huge numbers of moderately ill COVID-19 patients.”
Guys, B.1.640.2 isn’t new. It actually PREDATES Omicron. It's a sub-lineage of B.1.640- which caused some concern back in mid-November but couldn’t even compete with Delta. B.1.640.2 was first sequenced OVER a month ago and was officially recognized as a lineage in December.
As Tom points out, there haven’t been any new sequences uploaded since before Christmas and this variant has had a decent chance to cause issues but never really materialized. It’s been classified as a Variant Under Monitoring by WHO since November. Let’s focus on Omicron.
A CWRU School of Medicine study of 577,938 pediatric and adult patients shows first time SARS-CoV-2 infections occurring at a time when Omicron was rapidly spreading were associated with significantly less severe outcomes than first time infections when Delta predominated. 🧵
It is IMPORTANT to note severity of disease in humans is NOT determined only by virus replication but also by the host immune response to the infection. Make sure you are PROTECTED. Source for the information above can be found here: medrxiv.org/content/10.110… PLEASE NOTE.
Currently, data on the severity of the disease caused by the Omicron variant compared with the Delta variant has been limited. Here, researchers compared 3-day risks of emergency department (ED) visit, hospitalization, intensive care unit (ICU) admission, & mechanical ventilation
“Breakthrough” infections DO NOT mean vaccines don’t work. Remember, they are preventives, NOT cures. One can still contract COVID once vaccinated. As long as that vaccine is preventing you from facing severe disease and worse, it IS working and doing what it was designed to do.
The term infection refers to the virus entering and being detectable in your system regardless of whether OR NOT it makes you sick, whereas the term illness refers to the virus entering, being detectable in your system AND making you sick. It it important not to conflate the two.
The first thing to know about the COVID-19 vaccines is that they’re doing exactly what they were designed and authorized to do. Since the vaccines first started their rollout late last year, rates of COVID-19 disease have taken an unprecedented plunge among the immunized.
@_almond_tree May I make a suggestion. This isn’t new. The preprint just got uploaded like two days ago but that’s it. If anyone does a Google search they’ll see this pops up as early as October/November deseret.com/coronavirus/20… and hasn’t done much. Omicron kinda blew this out of the water.
@_almond_tree This has been under monitoring with B.1.640 being first detected in September 2021. ecdc.europa.eu/en/covid-19/va…. I know everyone is looking for the “next big thing” but context is important. The preprint just got uploaded on 12/29 which is why some people think it’s “new.”
@_almond_tree I mean, it didn’t even get to spread far due to Delta. Now with Omicron, if this variant couldn’t stand to Delta it likely wouldn’t be able to against Omicron either. Again, it’s been under monitoring, that’s it.