Mia Malan Profile picture
Jan 14, 2022 11 tweets 8 min read Read on X
[Thread] 1. What's happening with SA #Omicron hospital + death data?

Waasila Jassat, @nicd_sa:
"Decoupling" between cases, hospitalisations/deaths = continue.

Black: new #COVID19 cases
Grey: hospitalisations
Red: deaths

Cases higher than Wave 1-3, admissions/deaths = lower
2. #Omicron started in Gauteng + spread 2 other provinces within a week. With previous waves the spread 2 other parts of the country took much longer. So with #Omicron the peaks of provinces' hospitalisations/deaths = much closer to each other.
3. #Omicron hospital admissions in SA peaked at about 60% of the #Delta wave and deaths at about 14-15%
4. Excess deaths:
1. Top graph: excess deaths for under 60
2. Lower graph: excess deaths for 60+
3. Declines over past 2-3 weeks in excess deaths, but not yet for 60+. We're starting 2 see a plateau for 60+ (rise in cases for 60+ = later in wave, so expected 2 decline later)
5. How sick did #Omicron make people?
1. Data = Lancet preprint study
2. Median length of hospital stay:
- #Omicron: 4 days; #Delta: 6 days
3. Severe disease:
- Omicron: 31.7% of admissions; Delta: 63%
4. Deaths:
- Omicron: 9.7% of admissions, Delta: 26.4%
6. Graphs with the same data as in tweet 5, that show how sick each variant made people. Black = #Omicron data.

The % of admitted patients who required supplemental oxygen during the Omicron wave = less than half than of those who needed oxygen of the #Delta wave
7. Admissions of children:
1. Over 20 years: Lower % of admissions in this group for #Omicron (Omicron = 7.2% of cases; Delta: 12%)
2. Under 20 years: Higher % of admissions in this group for Omicron (Omicron = 8.4% of cases; Delta = 3.8%)
8. Although a larger % of younger people got admitted to hospital during #Omicron compared to other waves, they didn't fall as ill as during the other waves (so milder disease and shorter hospital stays).
9. Who got admitted to hospital with #COVID19 and who died during #Omicron?
1. 82% of admissions = unvaccinated people
2. Under 40 years (lower vaccination rates): 90-100% admissions = unvaccinated
3. 82% of deaths = unvaccinated

(vaccinations = self reported)
10. WHO evidence 4 #Omicron so far:
1. Higher % of asymptomatic infections
2. Omicron affects upper respiratory tract more than lower tract
3. Lower risk for hospitalisation
4. Increased risk of reinfection
5. Vaccine effectiveness @ hospitalisation much better than @ infection
11. Summary:
1. #Omicron cases/admissions = decreasing at slower rate than that it had increased
2. Hospitals in SA = not overwhelmed during Omicron
3. Milder disease and fewer deaths during Omicron wave
4. Most admissions + deaths = unvaccinated

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More from @miamalan

Jan 17
[Thread] 12 things to know about the the proportion of pregnant women infected with #HIV from SA’s latest antenatal HIV survey. The survey is conducted by the @nicd_sa.

(Analysis of our 95-95-95 goals in my next thread later in Jan).

1/12 Image
2. What is the antenatal #HIV survey?

1. It measures the % of HIV+ pregnant women between the ages of 15 + 49.
2. Only women using state pregnancy clinics take part.
3. The survey has been conducted each year between 1990-2015, then in 2017, 2019 +2022. Image
3. How many pregnant women between 15-49’s blood was tested for #HIV? 37 828 out of 40 542 collected samples.
- 37 7171 = Black African women
- 37 541 didn’t live with the dad of their child
- 35,635 of dads were 5 years+ older than moms (this makes them more likely to get HIV) Image
Read 12 tweets
Jan 10, 2023
JUST IN [Thread]:
1.@healthza's Lesley Broomberg:
An extra #COVID19 booster jab for people of 18+ in SA will become available towards the end of JANUARY
- People of 50+ qualify for a 5th dose
- People of 18+ qualify for a 4th dose
2. Lesley Broomberg: Can you mix and match with additional boosters? Yes. You can choose whether you want a #JnJ or #Pfizer booster.
3. Lesley Broomberg:
Will teens of 12-17 qualify for boosters? Not at this stage. Why not? The #VMAC = not recommended booster doses for 12-17, based on an understanding that the protection provided by 2 #Pfizer doses = adequate, as 12-17 = @ low risk of severe #COVID19 illness
Read 5 tweets
Jan 10, 2023
[Thread] #JoePhaahla:
- Genomic surveillance Network reported the detection of the new subvariant XBB.1.5 in SA of a sample of a patient tested on 22 Dec
- Details of the patient = not known, it was a random sample taken for testing
- XBB.1.5 = also common in US
2. XBB.1.5 = common in US
#JoePhaahla:
- 97%+ of #COVID19 cases worldwide = still #Omicron
- XBB.1.5 cases = no major change in hospitalisations or deaths
- Immunity of SAs (vax and natural immunity) = still strong, so that is why we haven't seen much change in terms of hospital admissions/deaths
Read 5 tweets
Dec 13, 2022
🧵1. SA's @aspenpharma will be making 4 jabs (fill + finish) — pneumococcal, rotavirus, meningococcal, hexavalent — from 2023.

How will they finance this?
With a $30 million grant from @CEPIvaccines + @gatesfoundation.

Which APIs will Aspen use?
India's Serum Institute's
2. Why is it NB that an African company makes these jabs?

#Africa imports almost all its jabs. #COVID19 showed us this results in Africa being last in line to get vaccines during pandemics. The grant to Aspen is 1 of the 1st steps to change that.
3. What's the goal?

By 2040, the African Union wants #Africa to make 60% of the jabs the continent uses.

Why?
So that Africa is better equipped 2 respond 2 outbreaks (by developing the ability to make jabs + have technology in place to also make new jabs during pandemics).
Read 6 tweets
Dec 2, 2022
🧵1. BREAKING: @SAHPRA1 has confirmed the registration of the #HIV prevention jab, #CABLA in South Africa. On Thursday, #ViiVHealthcare issued their statement. ImageImage
2. Who can use the jab? @SAHPRA1 didn't specify restrictions for use in their statement, only that it is "a highly effective option for people at substantial risk of #HIV infection." Image
3. How does the jab work? It uses an #ARV called cabotegravir that prevents #HIV from replicating and entering someone’s cells. It’s taken every two months. Read my latest story for more. bit.ly/3ER7ejq
Read 5 tweets
Dec 1, 2022
🧵1. @SAHPRA1 says it’s “days away” from announcing a decision on the registration of the #HIV prevention jab, #CABLA. The shot virtually wipes out your chances of contracting HIV through sex + needs to be taken every 2 months. bit.ly/3ER7ejq#WAD2022
2. How does the jab work? A bit like contraception, says @LindaGailBekker. “U take contraception before sex 2 prevent pregnancy. Similarly, u take the jab before being exposed 2 #HIV 2 prevent infection.” Listen 2 Linda-Gail on @bhekisisa’s #HealthBeat. bit.ly/3FjBlS8
3. What makes #CABLA work? An antiretroviral drug called cabotegravir. Some people with #HIV use it for treatment, along with other #ARVs. The drug prevents #HIV from entering your cells. bit.ly/3ER7ejq
Read 8 tweets

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