What we can learn from 20 waves ๐ of SARS-CoV-2?
A thread ๐งต 1/11
๐๐๐
The figure ๐ shows the strongest wave (โฌ๏ธgrey lines) in 20 countries around ๐ with the largest testing per capita. The peak is centered to be at day 0 and the cases are normalized to its height. Black: the averaged wave 2/11
We define a wave to start and finish with ยฝ of the cases in the peak. For instance, here is an example from Cyprus ๐จ๐พ. The peak (๐ด) at about 1100 daily cases per 1M. The wave's start & finish are labeled w/ an ๐งline at ~550 cases.
Gray: raw data
Blue: smoothed (our input)
3/11
Why are we interested only at ยฝ of the cases of the peak? 1. This is the time of last doubling. 2. As you well know, not all waves have strong valleys (here ๐is an example from Italy๐ฎ๐น). 3. In signal processing, pulse width is usually defined as ยฝ of the peak.
4/11
Back to the initial figure!
The average wave takes 49 days (SD=27days) with a median of 37 days ๐ฅด. Waves don't only feel long, but they are long...
5/11
Many people expect that the waves are symmetrical. In other words, they believe that it takes the same amount of time to go from half of the peak to the peak and from the peak back again to half of the cases.
Let's tests it empirically using 20 waves!
6/11
This density histogram (gray bars) shows the difference between the # days post-peak versus # days pre-peak (black: smoothed distribution).
In 75% of the waves, the post-wave was longer. And it was significantly longer (p<0.02, t-test), by 11 days on average!
7/11
๐ขAn intermediate summary: once the sh*t ๐ฉ hits the fan, it takes longer to go back to normal* than it takes to get to the peak from normal*.
*I say normal but our lives are anything but normal.
8/11
So post-waves are longer - but do they generate more cases?
The answer is YES!
The histogram shows the ratio between total cases in the post-wave compared to pre-wave (notice the log10 scale).
On average, post-waves generate 1.4x more cases than their pre-waves!
9/11
Final message:
Even if cases peaked and going down now in your area, watch out ๐. Most people will get Covid19 at the post-peak days than at the pre-peak days...
Stay safe!
10/11
PS:
All data from @OurWorldInData and using up to Oct 1st, 2021 data to avoid Omicron.
Peak and half-peak detection is automatic and uses Python Scipy peak detector.
Input for peak detection = smoothed cases using a Gaussian window of 14 days, std=5, centered.
11/11
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@sigallab did a fantastic job in framing the Abs response to Omicron. But his manuscript actually makes make me a bit concerned and I don't find the results encouraging. Let's dive in a short thread ๐งต๐
Just a reminder, the Omicron and the Delta are highly diverged from each other compared to the ancestral strain, which serves as the basis for the vaccine.
@sigallab enrolled 15 individuals who were infected by Omicron. Four people were vaccinated with J&J, 3 people with Pfizer, 6 were not vaxxed, 2 had no Ab response and were excluded from the study. These 13people were followed for ~2weeks.
If you recall, the police in GATTACA has access to Vincent's (the protagonist) eyelash. However, they can't identify him since he is not in any database. 2/5
We already at the point that nearly all US people can be identified via their DNA despite not being in any police database. How? about 1-2% of the US population took at DNA test that is searchable in 3rd party websites such as GEDmatch. 3/5
Excellent analysis by @IdoIrani about the waning booster effect (for infection) stratified by age group in Israel.
The worrying part: the rate of decline is most age groups is similar to the 2nd jab.
@IdoIrani This tweet is trending. So a few comments 1/2:
1 Data: datadashboard.health.gov.il/COVID-19/generโฆ 2. This is a tweet not peer reviewed publication. It is a preliminary analysis with some caveats as described here.
3. The y-axis should be crude VE 4. Some Idiots...
have said that since I am a CEO of a start up and @IdoIrani is a PhD student, the analysis should be disqualified. This is my Google Scholar. Hope it passes your high bar ๐คช. scholar.google.co.il/citations?userโฆ
5-โ. It is a preliminary signal.