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Feb 4 โ€ข 8 tweets โ€ข 3 min read
๐Ÿ“ข ื”ืžืืžืจ ืœื• ื—ื™ื›ื™ื ื• (ืขืดื™ ื”ืฆื•ื•ืช ื”ืžื•ื›ืฉืจ ืฉืœ ืคืื•ืฆืณื™ ื‘ @NIAIDNews).

ื”ืื ื›ื“ืื™ ืœื—ื›ื•ืช ืœื‘ื•ืกื˜ืจ ืžื•ืชืื ืื•ืžื™ืงืจื•ืŸ?
ื‘ืงืฆืจื”: ืœื! ๐Ÿคฏ
ื‘ืืจื•ืš: ืงื‘ืœื• ืฉืจืฉื•ืจ ๐Ÿงต๐Ÿ‘‡
biorxiv.org/content/10.110โ€ฆ
ื”ืจื‘ื” ืื ืฉื™ื ืžืชืœื‘ื˜ื™ื ืื ืœืงื—ืช ืืช ื”ื—ื™ืกื•ืŸ ื”ืจื‘ื™ืขื™ ืื• ืœื—ื›ื•ืช ืœื‘ื•ืกื˜ืจ ืžื•ืชืื ืื•ืžื™ืงืจื•ืŸ. ื”ืžืืžืจ ื”ื–ื” ืขืฉื” ืืช ื”ื“ื‘ืจ ื”ื‘ื:

ืฉืžื•ื ื” ๐Ÿ’ ืงื™ื‘ืœื• ๐Ÿ’‰๐Ÿ’‰ ืฉืœ ืžื•ื“ืจื ื” ืขื ื”ื—ื™ืกื•ืŸ ื”ืจื’ื™ืœ ืฉืœื”ื. ืชืฉืขื” ื—ื•ื“ืฉื™ื ืœืื—ืจ ืžื›ืŸ (41ืฉื‘ื•ืขื•ืช), ื”ื ื—ื•ืœืงื• ืœืฉืชื™ ืงื‘ื•ืฆื•ืช:
ืงื‘ื•ืฆื”1โƒฃ:ืงื™ื‘ืœื” ๐Ÿ’‰ ื‘ื•ืกื˜ืจ ืจื’ื™ืœ
ืงื‘ื•ืฆื”2โƒฃ: ืงื™ื‘ืœื” ๐Ÿ’‰ื‘ื•ืกื˜ืจ ืžื•ืชืื ืื•ืžื™ืงืจื•ืŸ
ืฉื‘ื•ืขื™ื™ื ืื—ืจ-ื›ืš, ื”ื—ื•ืงืจื™ื ื‘ื“ืงื• ืืช ืจืžืช ื”ื ื•ื’ื“ื ื™ื ื”ืžื ื˜ืจืœื™ื ืฉืœ ื›ืœ ืงื‘ื•ืฆื” ื›ื ื’ื“ ื›ืœ ื”ื–ื ื™ื ื”ื™ื“ื•ืขื™ื.
ืœื›ืœ ื”ื–ื ื™ื, ื”ื ื•ื’ื“ื ื™ื ืฉืœ ืงื‘ืณ 1โƒฃ (๐Ÿ’‰-ืจื’ื™ืœ) ื”ื™ื• ื‘ืจืžืช ื ื™ื˜ืจื•ืœ ื“ื•ืžื” ืœื ื•ื’ื“ื ื™ื ืžืงื‘ืณ 2โƒฃ(๐Ÿ’‰-ืื•ืžื™) ๐Ÿ˜ณ
๐Ÿ‘ื›ื•ืœืœ ืื•ืžื™ืงืจื•ืŸ๐Ÿ‘
ืชืจืื• ืืช ื‘ื’ืจืคื™ื ืืช ื”ืงื• ื”ืืคื•ืจ ื”ืฉืœื (๐Ÿ’‰-ืจื’ื™ืœ) ืžื•ืœ ื”ืžืงื•ื•ืงื• (ืื•ืžื™ืงืจื•ืŸ) ื‘ืฉื‘ื•ืข 43.
ืžื” ื”ืกื™ื‘ื” ืœื›ืš? ื–ื” ื›ื›ื”ืดื  ื” Original Antigen Sin. ื”ืจืขื™ื•ืŸ ื”ื•ื ืฉืžืขืจื›ืช ื”ื—ื™ืกื•ืŸ ืœืžื“ื” ื›ื‘ืจ ืื™ืš ื ืจืื” ืกืคื™ื™ืง ืดืจื’ื™ืœืด ื‘ื’ืœืœ ื”ื—ื™ืกื•ื ื™ื ื”ืงื•ื“ืžื™ื ื•ืื‘ื“ื” ื—ืœืง ืžื”ืคืœืกื˜ื™ื•ืช ืฉืœื”. ื–ื” ื›ืžื• ืฉืœื•ืžื“ื™ื ืื ื’ืœื™ืช ื‘ื’ื™ืœ ืžื‘ื•ื’ืจ - ื’ื ืื ื ื•ืจื ืชืจืฆื• ืชืฉืืจื• ืขื ืžื‘ื˜ื ื™ืฉืจืืœื™. ืื•ืชื• ื“ื‘ืจ ืขื ื”ื—ื™ืกื•ืŸ: ื ื’ืขืชื - ื ืกืขืชื.
ื”ืื ื–ื” ื‘ืขื™ื”? ื“ื•ื•ืงื ืœื! ืจืืฉื™ืช, ื—ื™ืกื•ืŸ ืžื•ืชืื ื”ื™ื” ืœื•ืงื— ื–ืžืŸ ืœื™ื™ืฆืจ ื•ืœื”ืคื™ืฅ ื•ื”ืžืืžืจ ื”ื–ื” ืžืฆื™ืข ืฉื”ืฆื•ืจืš ืžืชื™ื™ืชืจ. ืฉื ื™ืช, ื™ืฉ ื“ืื˜ื” ืžืขื•ืœื” ืฉืœ ืžืฉืจื“ ื”ื‘ืจื™ืื•ืช ื•ืžื›ื•ืŸ ื•ื•ื™ืฆืžืŸ ืฉืžืจืื” ืฉื‘ื•ืกื˜ืจ ื˜ืจื™ ืขื ื”ื—ื™ืกื•ืŸ ื”ืดืจื’ื™ืœืด ืžื•ืจื™ื“ ืืช ื”ืกื™ื›ื•ืŸ ืœื”ื“ื‘ืงื” ืคื™ 2 ื•ืœืžื—ืœื” ืงืฉื” ืคื™ 4! ืžืขืœ ื—ืฆื™ ืžื™ืœื™ื•ืŸ ๐Ÿ‡ฎ๐Ÿ‡ฑ ืœืงื—ื• ืœืœื ืชื•ืคืขื•ืช ืœื•ื•ืื™ ืžืฉืžืขื•ืชื™ื•ืช!
ืฉืœื™ืฉื™ืช, ื‘ื™ืฉืจืืœ ื’ื ื›ื›ื” ื”ืื•ืžื™ืงืจื•ืŸ BA.1 ื™ื•ืจื“ ื•ื–ืŸ BA.2 ืขื•ืœื” ื•ื”ื•ืœืš ืœื”ืฉืชืœื˜ ื›ื ืจืื” ืชื•ืš ืžืกืคืจ ืฉื‘ื•ืขื•ืช ืžื•ืขื˜. ืฉื ื™ ื”ื–ื ื™ื ื”ืืœื” ืฉื•ื ื™ื ืžืื“ ื‘ืกืคื™ื™ืง ืฉืœื”ื ื‘ 20 ืžื•ื˜ืฆื™ื•ืช. ื’ื ืื ื”ื™ื” ื—ื™ืกื•ืŸ ืžื•ืชืื ืœ BA.1 (ืฉื–ื” ืžื” ืฉื”ืžืืžืจ ื“ื™ื‘ืจ ืขืœื™ื•), ื”ื•ื ื›ื‘ืจ ืขืฉื•ื™ ืœื”ื™ื•ืช obsolete ื‘ื™ื•ื ืฉื”ื•ื ื™ืฆื.
ื”ืื ื›ื“ืื™ ืœื ืœืงื—ืช ืฉื•ื ื—ื™ืกื•ืŸ ื•ืคืฉื•ื˜ ืœืชืช ืœืื•ืžื™ืงืจื•ืŸ ืœืขืฉื•ืช ืืช ืฉืœื•? ื’ื ืœื.
ืžื—ืงืจื™ื ืžืจืื™ื ืฉื”ื“ื‘ืงื” ื‘ืื•ืžื™ืงืจื•ืŸ ืืฆืœ ืœื-ืžื—ื•ืกื ื™ื ื™ื•ืฆืจืช ื ื•ื’ื“ื ื™ื ืžื ื˜ืจืœื™ื ื‘ืจืžื” ืžืขื˜ื” ืžืื“ ื›ื ื’ื“ ื›ืœ ื”ื–ื ื™ื **ื›ื•ืœืœ ืื•ืžื™ืงืจื•ืŸ** (ืจืื• ืขืžื•ื“ื” ืกื’ื•ืœื” ื‘ figure B ื‘ืฆื™ื•ืฅ ื”ืžืฆื•ืจืฃ). ื”ื›ื™ ื˜ื•ื‘ ื–ื” ืœื—ืกืŸ ืขื ืžื” ืฉื™ืฉ!

ืžืงื•ื•ื” ืฉื ื”ื™ื ืชื.

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More from @erlichya

Yaniv Erlich Profile picture
Feb 4
๐Ÿ“ข The study we all waited for by the brilliant team at the VRC/@NIAIDNews

Should we wait for an Omicron-specific booster?
Short answer: No ๐Ÿคฏ

Long answer: A thread ๐Ÿงต๐Ÿ‘‡
The main question that many people contemplate is should I wait for an Omicron-specific booster or not?

Eight ๐Ÿ’ received ๐Ÿ’‰๐Ÿ’‰ of the regular (WT) Moderna vaccine.
Then, 41-weeks later, they were split into 2 arms:
1โƒฃGot a regular (WT) ๐Ÿ’‰ booster
2โƒฃGot an Omicron ๐Ÿ’‰ booster
2 weeks later, the team checked the neuts levels from each arm against various viral strains.
For ALL strains the neuts level of Arm2โƒฃ (Omi๐Ÿ’‰) were NOT better than Arm1โƒฃ (WT๐Ÿ’‰)
This was also true for Omicron ๐Ÿ˜ณ. Look at gray lines at w#43 in both graphs (WT: solid; O: broken)
Read 9 tweets
Yaniv Erlich Profile picture
Jan 18
ื‘ื ื™ื’ื•ื“ ืœื“ืขื” ื”ืจื•ื•ื—ืช, ืชืขืฉื™ื™ืช ื”ืคืืจืžื” ืฉื•ื ืืช ืืช ื”ืคื ื“ืžื™ื”.
ืฉืจืฉื•ืจ ืขืœ ื”ืชื™ื™ื‘ืฉื•ืช ื” pipeline ืขื ืžื‘ื˜ ืœื˜ื•ื•ื— ื”ื‘ื™ื ื•ื ื™ ื•ืœื ื™ื”ื•ืœ ื”ืžื’ื™ืคื”.

ื’ื™ืœื•ื™ ื ืื•ืช: ื”ืกื˜ืืจื˜-ืืค ืฉืœื™ ืžืชืขืกืง ื‘ืชื—ื•ื.
๐Ÿงต
ืคื™ืชื•ื— ืชืจื•ืคื•ืช ื”ื•ื ืชื”ืœื™ืš ืขืชื™ืจ ืกื™ื›ื•ืŸ ืžื‘ื—ื™ื ื” ืื™ื ืจื ื˜ื™ืช. ืžื•ืœืงื•ืœื” ืฉืขื•ื‘ื“ืช ื ื”ื“ืจ ื‘ืชืื™ื, ืขืœื•ืœื” ืœื ืœืขื‘ื•ื“ ื‘ืขื›ื‘ืจ. ืžื•ืœืงื•ืœื” ืฉืขื•ื‘ื“ืช ื‘ืขื›ื‘ืจ, ืคืชืื•ื ืœื ืขื•ื‘ื“ืช ื‘ืงื•ืฃ. ืžื” ืฉืขื‘ื“ ื‘ื—ื™ื•ืช ื›ื‘ืจ ืœื ืขื•ื‘ื“ ื‘ื‘ื ื™ ืื“ื, ื•ื›ื•ืณ. ื”ื‘ื™ื•ืœื•ื’ื™ื” ื”ื™ื ืื›ื–ืจื™ืช ื•ืœื ื ืชื•ื ื” ืœื—ื™ื–ื•ื™ ืžืœื. ืื‘ืœ ื–ื” ืกื™ื›ื•ืŸ ืฉื—ื‘ืจื•ืช ืคืืจืžื” ื™ื•ื“ืขื•ืช ืœืงื—ืช. ืžื” ื”ื ืฉื•ื ืื•ืช?
ื”ื ืฉื•ื ืื•ืช ืฉื™ืฉ ืกื™ื›ื•ื ื™ื ืขืกืงื™ื™ื ืขื ืงื™ื™ื ืžืขื‘ืจ ืœืกื™ื›ื•ืŸ ื”ื‘ื™ื•ืœื•ื’ื™. ื ื ื™ื—, ืื ืืชื ืขื•ื‘ื“ื™ื ืขืœ ืืœืฆื”ื™ื™ืžืจ, ืืชื ื™ื•ื“ืขื™ื ืฉืืœืฆื”ื™ื™ืžืจ ืชืžื™ื“ ื™ื”ื™ื”. ืื™ืŸ ืฉืืœื” ืฉื™ืฉ ืฉื•ืง ื•ืฉื™ืฉ ืฆื•ืจืš ืื“ื™ืจ ื‘ืชืจื•ืคื” ื›ื–ืืช.

ื‘ืคื ื“ืžื™ื” ื–ื” ืœื ื›ื›ื”. ื”ืฉื•ืง ื”ื•ื ื‘ื›ืœืœ ืœื ื‘ืจื•ืจ ื•ื–ื– ื›ืœ ื”ื–ืžืŸ ื‘ืงืฆื‘ ืืงืกืคื•ื ื ื™ืืœื™ ืœื›ืœ ื”ื›ื™ื•ื•ื ื™ื. ื•ืœื›ืŸ, ื”ืชืขืฉื™ื™ื” ืฉื•ื ืืช ืืช ื–ื”.
Read 14 tweets
Yaniv Erlich Profile picture
Jan 16
What we can learn from 20 waves ๐ŸŒŠ of SARS-CoV-2?
A thread ๐Ÿงต 1/11
๐Ÿ‘‡๐Ÿ‘‡๐Ÿ‘‡
The figure ๐Ÿ‘† shows the strongest wave (โฌ›๏ธgrey lines) in 20 countries around ๐ŸŒ with the largest testing per capita. The peak is centered to be at day 0 and the cases are normalized to its height. Black: the averaged wave 2/11
We define a wave to start and finish with ยฝ of the cases in the peak. For instance, here is an example from Cyprus ๐Ÿ‡จ๐Ÿ‡พ. The peak (๐Ÿ”ด) at about 1100 daily cases per 1M. The wave's start & finish are labeled w/ an ๐ŸŸงline at ~550 cases.
Gray: raw data
Blue: smoothed (our input)
3/11
Read 11 tweets
Yaniv Erlich Profile picture
Dec 28, 2021
@sigallab did a fantastic job in framing the Abs response to Omicron. But his manuscript actually makes make me a bit concerned and I don't find the results encouraging. Let's dive in a short thread ๐Ÿงต๐Ÿ‘‡
Just a reminder, the Omicron and the Delta are highly diverged from each other compared to the ancestral strain, which serves as the basis for the vaccine.
@sigallab enrolled 15 individuals who were infected by Omicron. Four people were vaccinated with J&J, 3 people with Pfizer, 6 were not vaxxed, 2 had no Ab response and were excluded from the study. These 13people were followed for ~2weeks.
Read 8 tweets
Yaniv Erlich Profile picture
Dec 24, 2021
ืžืืžืจ ืกื•ืคืจ ืžืขื ื™ื™ืŸ ืขืœ ื”ืžื›ื ื™ื–ื ืฉืœ cell entry ื‘ืื•ืžื™ืงืจื•ืŸ ืœืขื•ืžืช ื“ืœืชื ื• wuhan ื•ืœืžื” ื”ื•ื ืื•ืœื™ ืคื—ื•ืช ื•ื™ืจื•ืœื ื˜ื™. ืฉืจืฉื•ืจ ืงืฆืจ ืฉืžืกื‘ื™ืจ ืžื” ื”ื•ืœืš ื›ืืŸ.

biorxiv.org/content/10.110โ€ฆ
ื›ื•ืœื ื• ืฉืžืขื ื• ืขืœ Spike ื•ืขืœ ื›ืš ืฉื”ื•ื ื ืงืฉืจ ืœ ACE2 ื›ื“ื™ ืœื”ื›ื ืก ืœืชื•ืš ื”ืชืื™ื. ืื‘ืœ ื”ืชื”ืœื™ืš ื”ื–ื” ื”ื•ื ืžืื“ ืœื ืคืฉื•ื˜. ื›ืžื• ืฉืืชื ืžื›ื ื™ืกื™ื ืžืคืชื— ืœืชื•ืš ืžื ืขื•ืœ ื•ืฆืจื™ื›ื™ื ืงืฆืช ืœื ืขืจ ืืช ื”ืžืคืชื— ืฉื™ื›ื ืก ื‘ืงืœื•ืช, ื’ื ื”ืกืคื™ื™ืง ืฆืจื™ืš ืงืฆืช ื“ืจื’ื•ืช ื—ื•ืคืฉ ื›ื“ื™ ืœื”ื™ืงืฉืจ ื˜ื•ื‘ ืœ ACE2 ื•ืœื‘ืฆืข ืืช ื”ื›ื ื™ืกื” ืœืชื.
ื›ืืŸ ืžื’ื™ืข ืœืขื–ืจืชื• ืฉืœ ื”ืกืคื™ื™ืง ืจืฆืคื˜ื•ืจ ื ื•ืกืฃ ืฉื ืงืจื TMPRSS2. ื”ืจืฆืคื˜ื•ืจ ื”ื–ื” ื”ื•ื ืคืฉื•ื˜ ืกื›ื™ืŸ ืฉื—ื•ืชื›ืช ื—ืœื‘ื•ื ื™ื. ื”ื•ื ื—ื•ืชืš ืืช ื”ืกืคื™ื™ืง ื›ืžื• ืฉื—ื•ืชื›ื™ื ื‘ืžื•ื“ืขืช ืชืœื™ืฉื” ื•ื–ื” ื•ื ื•ืชืŸ ืœืกืคื™ื™ืง ืขื•ื“ ื“ืจื’ื•ืช ื—ื•ืคืฉ ืฉื”ื•ื ืฆืจื™ืš ืœืงื™ืฉื•ืจ ืžื™ื˜ื‘ื™ ืœ ACE2.
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Yaniv Erlich Profile picture
Dec 23, 2021
Want to produce Paxlovid, Pfizer's new antiviral?

All you need to do is to follow the simple process in the short thread below.
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