Key messages.
Long covid is not psychosomatic.
Serious pathology is evident when the correct investigations done.
Many long haulers have been unwell now for nearly 2 years; we are unlikely to get better on our own.
Long covid is not psychosomatic.
Serious pathology is evident when the correct investigations done.
Many long haulers have been unwell now for nearly 2 years; we are unlikely to get better on our own.
https://twitter.com/doctorasadkhan/status/1491187647548575746
All long haulers whose blood has been tested has been positive for microclots
1 in 10 people will experience Long Covid. Prevention is key.
Long Covid patients present differently, with different, but often overlapping, symptoms.
1 in 10 people will experience Long Covid. Prevention is key.
Long Covid patients present differently, with different, but often overlapping, symptoms.
Things we have to ask ourselves:
What is driving microclot formation? A damaged endothelium will do this.
We know the virus can directly damage the endothelium
What is driving microclot formation? A damaged endothelium will do this.
We know the virus can directly damage the endothelium
https://twitter.com/laurie_garrett/status/1487498127032659971
What is continuing to drive clot formation? viral persistence/debris and/or endothelial damage/inflammation?
While ever there are clots in our circulation and vascular inflammation, gasious exchange across this surface will be impaired.
While ever there are clots in our circulation and vascular inflammation, gasious exchange across this surface will be impaired.
Our tissues are oxygen starved. Mitochondria (the powerhouse of our cell which produces energy) Cannot respire aerobically without a sufficient supply of oxygen.
Although long haulers present with different symptoms, there will be a common thread.
What is common throughout our body systems? Blood vessels, nerves, the immune system, the virus
What is common throughout our body systems? Blood vessels, nerves, the immune system, the virus
There is also evidence of autoimmunity. After Covid, some patients are going on to develop conditions such as rheumatoid arthritis & diabetes.
Viral persistence can trigger autoimmunity.
Viral persistence can trigger autoimmunity.
Eventually all of the pieces of the jigsaw - research on micro clots, viral persistence, autoimmunity - will come together.
If I had to make a guess it would be this:
If I had to make a guess it would be this:
Viral persistence > triggering autoimmunity
Viral damage of endothelium > ongoing vascular inflammation/viral debris/viral persistence driving micro-clot formation > impaired gaseous exchange > anaerobic respiration/ tissue hypoxia
Viral damage of endothelium > ongoing vascular inflammation/viral debris/viral persistence driving micro-clot formation > impaired gaseous exchange > anaerobic respiration/ tissue hypoxia
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