This one suggests that individuals with high serum microRNA-122 levels may be less responsive during diet/physical activity-induced weight loss, as far as hepatic fat content loss is concerned.
- In the current study of participants with abdominal obesity or dyslipidemia from an 18-month randomized, controlled diet and physical activity intervention trial, it was observed that serum miR-122 levels were positively associated with hepatic fat percentage at baseline.
- A greater elevation in miR-122 from baseline to 18 months was associated with a smaller reduction in hepatic fat content during the 18-month intervention process.
- The association of changes in miR-122 with hepatic fat content changes was modified by baseline fasting plasma glucose, as the association was stronger among participants with higher fasting plasma glucose levels.
Circulating Levels of microRNA-122 and Hepatic Fat Change in Response to Weight-Loss Interventions: CENTRAL Trial
doi.org/10.1210/clinem…
#MetabolicSyndrome #InsulinResistance #NAFLD
doi.org/10.1210/clinem…
#MetabolicSyndrome #InsulinResistance #NAFLD
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