Just published @nature
The impact of #Covid on the brain: the 1st longitudinal imaging study before and after infection, with controls
nature.com/articles/s4158…
Reduction of grey matter, brain size, cognitive decline

Demographics of Covid cases and controls. Only 15 of cases were hospitalized and results did not change when they were deleted from analysis

@OxfordWIN

One of the most important studies of the pandemic; further work to determine reversibility needed. Credit @OxfordWIN @uk_biobank Gwenaelle Douaud and colleagues for this contribution

Read 4 tweets

Eric Topol

@EricTopol

Mar 5

@OurWorldInData

4 Asian-Pacific countries have experienced severe Omicron waves, but only 1 has an extremely high death toll. Why? /1
@OurWorldInData

There's a marked difference in vaccination and boosters /2

@ThomasHHChan

This is especially the case for the elderly /3
ft.com/content/2fc339… by @ThomasHHChan @primroseriordan @imandylin2 @FT

Read 7 tweets

Eric Topol

@EricTopol

Feb 20

@guardian

My new essay @guardian
"Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed"
theguardian.com/commentisfree/…
Summarizes extensive new evidence that confirmed Prior Covid ("Natural Immunity" or NI) + 1-shot is as protective as 3-shots /1

These 6 new reports (5 in the last week) all demonstrate that NI + 1-shot provides a consistent high level of added protection from reinfection, across multiple variants, which is not ameliorated by additional shots /2

@NEJM

I've reviewed considerable other new data here, such as the J&J vaccine randomized, placebo-controlled trial report last wk @NEJM which showed NI had superior protection vs moderate-to-severe Covid than 1-shot of the vaccine (90% vs 56%, respectively)
erictopol.substack.com/p/ground-truth… /3

Read 5 tweets

Eric Topol

@EricTopol

Feb 18

@CDCgov

New @CDCgov
Proof of benefit of vaccine booster for protection from Covid hospitalization in young, age 18-49, as previously documented in other countries
covid.cdc.gov/covid-data-tra…
77% reduction with 2-shots
94% reduction with booster

All ages, 18+
2-shot reduction of hospitalization 76%
3-shot reduction of hospitalization 93%

Remarkable consistency across age groups for reduction of hospitalization for 2-shot and booster vaccination vs unvaccinated
2-shot 3-shot
Age 18-49 77% 94%
Age 50-64 79% 92%
Age 65+ 74% 94%

Read 5 tweets

Eric Topol

@EricTopol

Feb 13

We've learned a lot about Prior Covid ("Natural Immunity") over the past year, but the US/CDC continues to negate the abundant evidence for it providing any protection
erictopol.substack.com/p/ground-truth… w/links
And there's substantial new data, I'll review🧵here /1

@NEJM

Last week, the large J&J 1- shot, placebo-controlled trial w/ >2,000 participants who had Prior Covid published @NEJM
Vaccine effectiveness vs moderate/severe disease
Prior Covid 90%
J&J Vaccine 56%
Yet 1-shot J&J vaccine = "fully vaccinated" @CDCgov
Nothing for Prior Covid /2

Neutralizing antibodies after Prior Covid are present out to 16 months in 214 people (graph)
And another study showing persistence of memory B cells at 15 months /3

Read 13 tweets

Share this page!

Eric Topol

People who liked this thread also liked...

Try unrolling a thread yourself!

More from @EricTopol

Eric Topol

Eric Topol

Eric Topol

Eric Topol

Eric Topol

Eric Topol

Did Thread Reader help you today?

Don't want to be a Premium member but still want to support us?

Like this author's thread?