Chris Martey Profile picture
Mar 15 11 tweets 11 min read
The Gut #Microbiome is implicated in the pathogenesis of inflammatory arthritides & other health conditions

Gut dysbiosis is a broad term relating to an 'imbalance' of gut microbiota associated with an unhealthy outcome

I find this an interesting topic with several unknowns

🧵 Image
"Gut inflammation is strongly associated with #Spondyloarthritis (SpA), as exemplified by the high prevalence of inflammatory bowel disease (IBD) and the even higher occurrence of subclinical gut inflammation in patients with #SpA."… Image
"Gut #Microbiome composition differs across regions and ethnicities, changes over time, and can be influenced by multiple factors, including, among others, diet, lifestyle, hormonal cycles, disease, comorbidity..."

'Gut microbiome in #Rheumatic diseases'… Image
There has been acknowledgement of gut dysbiosis in #RA too…

➡️ Alterations in microbial flora occurs in preclinical & established #RheumatoidArthritis

And here in, 'Intestinal Dysbiosis and #Rheumatoid Arthritis'… Image
This paper gives an excellent overview on the gut #Microbiome,

'The metabolic role of the gut #Microbiota in health and #Rheumatic disease: mechanisms and interventions'…

Via @NatRevRheumatol Image
There is also emerging evidence which makes reference to the gut #Microbiome and degenerative diseases such as #Osteoarthritis



Though more research is needed. ImageImage
This paper explores the relationship between #Depression, skin #Psoriasis and the #GutMicrobiome

Coined the Gut-Brain-Skin Axis 🧠… ImageImage
And what about ageing?

'Is inflammageing influenced by the #Microbiota in the aged gut? A systematic review'…
The links seem vast when considering gut inflammation and the #Microbiome

It'll be fascinating watching this body of evidence develop and how clinical practice will subsequently change.

For example, what role does #Exercise have to play? Image
This article poses some thoughts in relation to the role of #Exercise on the gut in older people with #Osteoarthritis… Image
I'd love to hear from clinicians who are confidently discussing gut health with their patients, especially those in #Rheumatology

Rosenbaum's work was my first insight into this topic

'The #Microbiome: a Revolution in Treatment for Rheumatic Diseases?'

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