Eric Topol Profile picture
Mar 16 4 tweets 2 min read
When South Korea, a model country for the pandemic, has >400,000 new cases in a day, leading the world per capita, you take notice. Tests 4X the US with <1/6th the population. BA.2 is 26% as of this week's report.
Very high 2-shot vaxx 87%, 3-shot 63%. The pandemic isn't over.
Relative to Hong Kong, it's death rate is very low. Boosters more than double. Great coverage of age 60+ No Sinovac vaccines.
BTW Hong Kong's booster 30% rate now exceeds the US (29%)
Relative to European countries with a BA.2-related hospitalization increase, South Korea's (BA.1) is more pronounced
Adding Vietnam as a comparator, 3 places (+ Hong Kong) w/ minimal Prior Covid and pronounced Omicron case surges
Hong Kong w/ extreme fatality rate, first signs of slowing
Vietnam's level of protection is impressive despite less vaccine coverage than South Korea
@OurWorldInData

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More from @EricTopol

Mar 12
A review of the latest @UKHSA report
assets.publishing.service.gov.uk/government/upl…
1. Booster shots have prevented about 160,000 hospitalizations in England during the Omicron wave
2. The falloff of effectiveness vs Omicron over time is striking. Here VE for age 50+ against mortality
3. Also seen vs hospitalizations by 10+ weeks
Read 6 tweets
Mar 10
This represents phenomenal progress, folks.
The immunity wall in England has now led to Covid carrying (slightly) *less* fatality risk than seasonal flu
ft.com/content/e26c93… @FT @jburnmurdoch @mroliverbarnes
That's even the case for people of advanced age
Consider that Covid started with a ~18-fold increased mortality compared with influenza for people age 60+
Read 4 tweets
Mar 10
US Covid hospitalizations descend to their lowest level in over 8 months, and below all but 1 of its pandemic waves👍
It doesn't mean we're out of the woods.
Keep in mind that in England hospital admissions have started to rise again
ft.com/content/e26c93…
Possible explanations and implication, @chrischirp
Read 4 tweets
Mar 7
Just published @nature
The impact of #Covid on the brain: the 1st longitudinal imaging study before and after infection, with controls
nature.com/articles/s4158…
Reduction of grey matter, brain size, cognitive decline
Demographics of Covid cases and controls. Only 15 of cases were hospitalized and results did not change when they were deleted from analysis
One of the most important studies of the pandemic; further work to determine reversibility needed. Credit @OxfordWIN @uk_biobank Gwenaelle Douaud and colleagues for this contribution
Read 4 tweets
Mar 5
4 Asian-Pacific countries have experienced severe Omicron waves, but only 1 has an extremely high death toll. Why? /1
@OurWorldInData
There's a marked difference in vaccination and boosters /2
This is especially the case for the elderly /3
ft.com/content/2fc339… by @ThomasHHChan @primroseriordan @imandylin2 @FT
Read 7 tweets
Feb 20
My new essay @guardian
"Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed"
theguardian.com/commentisfree/…
Summarizes extensive new evidence that confirmed Prior Covid ("Natural Immunity" or NI) + 1-shot is as protective as 3-shots /1
These 6 new reports (5 in the last week) all demonstrate that NI + 1-shot provides a consistent high level of added protection from reinfection, across multiple variants, which is not ameliorated by additional shots /2
I've reviewed considerable other new data here, such as the J&J vaccine randomized, placebo-controlled trial report last wk @NEJM which showed NI had superior protection vs moderate-to-severe Covid than 1-shot of the vaccine (90% vs 56%, respectively)
erictopol.substack.com/p/ground-truth… /3
Read 5 tweets

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