Israel's findings of protection for the 3rd and 4th dose are quite different, both in people age 60+, early read out at just 12+ days
3rd shot (Delta wave): ~15-fold protection vs severe illness
4th shot (Omicron wave): ~4-fold protection vs severe illness
3rd shot (Delta wave): ~15-fold protection vs severe illness
4th shot (Omicron wave): ~4-fold protection vs severe illness
Whereas the 3rd shot had durable protection vs severe illness for 4+ months, the 4th (vs Omicron, w/ far more immune evasion), may be limited
https://twitter.com/erlichya/status/1503686291300487172
They've worked remarkably well vs severe disease, with a 3rd shot that restored effectiveness at ~95% vs hospitalization and death.
But the virus has continued to evolve, the antigenic distance between Omicron BA.1 and BA.2 is as far as Beta to Gamma.
But the virus has continued to evolve, the antigenic distance between Omicron BA.1 and BA.2 is as far as Beta to Gamma.
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