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Mar 19 • 6 tweets • 2 min read
Europe's BA.2 variant ascent continues
Hospitalizations on the rise in several countries
“We’ve been wearing rose-colored glasses instead of correcting our vision.”--@arimoin
nytimes.com/2022/03/19/hea…
Updated virus wastewater surveillance in limited 468 sites that monitor
10% have increases 1,000% or more
covid.cdc.gov/covid-data-tra…
Early indicators in case rises

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More from @EricTopol

Eric Topol Profile picture
Mar 20
Israel's findings of protection for the 3rd and 4th dose are quite different, both in people age 60+, early read out at just 12+ days
3rd shot (Delta wave): ~15-fold protection vs severe illness
4th shot (Omicron wave): ~4-fold protection vs severe illness ImageImage
Whereas the 3rd shot had durable protection vs severe illness for 4+ months, the 4th (vs Omicron, w/ far more immune evasion), may be limited
They've worked remarkably well vs severe disease, with a 3rd shot that restored effectiveness at ~95% vs hospitalization and death.
But the virus has continued to evolve, the antigenic distance between Omicron BA.1 and BA.2 is as far as Beta to Gamma. Image
Read 4 tweets
Eric Topol Profile picture
Mar 16
When South Korea, a model country for the pandemic, has >400,000 new cases in a day, leading the world per capita, you take notice. Tests 4X the US with <1/6th the population. BA.2 is 26% as of this week's report.
Very high 2-shot vaxx 87%, 3-shot 63%. The pandemic isn't over.
Relative to Hong Kong, it's death rate is very low. Boosters more than double. Great coverage of age 60+ No Sinovac vaccines.
BTW Hong Kong's booster 30% rate now exceeds the US (29%)
Relative to European countries with a BA.2-related hospitalization increase, South Korea's (BA.1) is more pronounced
Read 4 tweets
Eric Topol Profile picture
Mar 12
A review of the latest @UKHSA report
assets.publishing.service.gov.uk/government/upl…
1. Booster shots have prevented about 160,000 hospitalizations in England during the Omicron wave
2. The falloff of effectiveness vs Omicron over time is striking. Here VE for age 50+ against mortality
3. Also seen vs hospitalizations by 10+ weeks
Read 6 tweets
Eric Topol Profile picture
Mar 10
This represents phenomenal progress, folks.
The immunity wall in England has now led to Covid carrying (slightly) *less* fatality risk than seasonal flu
ft.com/content/e26c93… @FT @jburnmurdoch @mroliverbarnes
That's even the case for people of advanced age
Consider that Covid started with a ~18-fold increased mortality compared with influenza for people age 60+
Read 4 tweets
Eric Topol Profile picture
Mar 10
US Covid hospitalizations descend to their lowest level in over 8 months, and below all but 1 of its pandemic waves👍
It doesn't mean we're out of the woods.
Keep in mind that in England hospital admissions have started to rise again
ft.com/content/e26c93…
Possible explanations and implication, @chrischirp
Read 4 tweets
Eric Topol Profile picture
Mar 7
Just published @nature
The impact of #Covid on the brain: the 1st longitudinal imaging study before and after infection, with controls
nature.com/articles/s4158…
Reduction of grey matter, brain size, cognitive decline
Demographics of Covid cases and controls. Only 15 of cases were hospitalized and results did not change when they were deleted from analysis
One of the most important studies of the pandemic; further work to determine reversibility needed. Credit @OxfordWIN @uk_biobank Gwenaelle Douaud and colleagues for this contribution
Read 4 tweets

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