Share this page!

Eric Topol Profile picture
Twitter logo
Mar 24 • 4 tweets • 2 min read
New @UKHSA report on booster vaccine effectiveness waning vs Omicron hospitalization (≥ 2 days w/ respiratory illness)
Age 18-64: 91% declined to 67% after 105 days
assets.publishing.service.gov.uk/government/upl…
No difference BA.1 vs BA.2 seen for VE vs hospitalization; both fall ~20 per cent points after 70 days
Nearly 200,000 Covid hospitalizations are estimated to have been prevented by boosters, age 25+, since mid-December
Keep in mind the UK booster rate is 2-times the US and 2-dose vaccine protection vs Omicron hospitalization (BA.1 or BA.2) is poor (VE 30-50% after waning) without a booster

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Eric Topol

Eric Topol Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @EricTopol

Eric Topol Profile picture
Mar 22
🆕 @TheLancetEndo
The ~40% increased risk of diabetes, in people with Covid, not present at 1 month, but manifest at 1-year follow-up
thelancet.com/journals/landi… among 180,000 infectees vs 4.3 million controls #LongCovid @zalaly Image
This is consistent with report last week
Coverage of this paper @wsy by @rddysum
wsj.com/articles/new-r…
Read 4 tweets
Eric Topol Profile picture
Mar 21
The 4th shot is already underway in the UK. Meanwhile, millions of Americans of advanced age are well past 6 months from getting their 3rd shot, with substantial waning of protection, with no plan yet. /1
Reduction in neutralizing antibodies after mRNA vaccines at 5 months /2
nejm.org/doi/full/10.10…
Waning in vaccine effectiveness vs Omicron symptomatic infections and hospitalizations after 3rd dose, all ages @UKHSA /3
assets.publishing.service.gov.uk/government/upl…
Read 7 tweets
Eric Topol Profile picture
Mar 20
Israel's findings of protection for the 3rd and 4th dose are quite different, both in people age 60+, early read out at just 12+ days
3rd shot (Delta wave): ~15-fold protection vs severe illness
4th shot (Omicron wave): ~4-fold protection vs severe illness
Whereas the 3rd shot had durable protection vs severe illness for 4+ months, the 4th (vs Omicron, w/ far more immune evasion), may be limited
They've worked remarkably well vs severe disease, with a 3rd shot that restored effectiveness at ~95% vs hospitalization and death.
But the virus has continued to evolve, the antigenic distance between Omicron BA.1 and BA.2 is as far as Beta to Gamma.
Read 4 tweets
Eric Topol Profile picture
Mar 19
Europe's BA.2 variant ascent continues
Hospitalizations on the rise in several countries
“We’ve been wearing rose-colored glasses instead of correcting our vision.”--@arimoin
nytimes.com/2022/03/19/hea…
Read 6 tweets
Eric Topol Profile picture
Mar 16
When South Korea, a model country for the pandemic, has >400,000 new cases in a day, leading the world per capita, you take notice. Tests 4X the US with <1/6th the population. BA.2 is 26% as of this week's report.
Very high 2-shot vaxx 87%, 3-shot 63%. The pandemic isn't over.
Relative to Hong Kong, it's death rate is very low. Boosters more than double. Great coverage of age 60+ No Sinovac vaccines.
BTW Hong Kong's booster 30% rate now exceeds the US (29%)
Relative to European countries with a BA.2-related hospitalization increase, South Korea's (BA.1) is more pronounced
Read 4 tweets
Eric Topol Profile picture
Mar 12
A review of the latest @UKHSA report
assets.publishing.service.gov.uk/government/upl…
1. Booster shots have prevented about 160,000 hospitalizations in England during the Omicron wave
2. The falloff of effectiveness vs Omicron over time is striking. Here VE for age 50+ against mortality
3. Also seen vs hospitalizations by 10+ weeks
Read 6 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us on Twitter!

Like this author's thread?

Get emails when @EricTopol has new unrolls!

Check out other threads from @EricTopol!

Read all threads by @EricTopol

:(